Patents by Inventor Paul D. Drumheller

Paul D. Drumheller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200139020
    Abstract: According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.
    Type: Application
    Filed: January 3, 2020
    Publication date: May 7, 2020
    Inventors: Per Antoni, Karin Leontein, Mei Li, Robert L. Cleek, Paul D. Drumheller
  • Patent number: 10561766
    Abstract: According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: February 18, 2020
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Per Antoni, Karin Leontein, Mei Li, Robert L. Cleek, Paul D. Drumheller
  • Publication number: 20190247306
    Abstract: The present invention relates to articles and methods of treating vascular conditions with a thixotropic, turbid, bioactive agent-containing gel material capable of being essentially removed from an implantation site upon re-establishment of fluid flow at the implantation site.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 15, 2019
    Inventors: Robert L. Cleek, Paul D. Drumheller, Theresa A. Holland
  • Publication number: 20190224323
    Abstract: The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
    Type: Application
    Filed: April 1, 2019
    Publication date: July 25, 2019
    Inventors: Robert L. Cleek, Edward H. Cully, Paul D. Drumheller, Theresa A. Holland
  • Patent number: 10314783
    Abstract: The present invention relates to articles and methods of treating vascular conditions with a thixotropic, turbid, bioactive agent-containing gel material capable of being essentially removed from an implantation site upon re-establishment of fluid flow at the implantation site.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: June 11, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Paul D. Drumheller, Theresa A. Holland
  • Publication number: 20190000979
    Abstract: The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Inventors: Robert L. Cleek, Edward H. Cully, Paul D. Drumheller, Theresa A. Holland
  • Patent number: 10092653
    Abstract: The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: October 9, 2018
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Edward H. Cully, Paul D. Drumheller, Theresa A. Holland
  • Publication number: 20180125632
    Abstract: An implantable containment apparatus for receiving and retaining a plurality of cells for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a chamber having structural spacers therein to maintain an average distance between the first interior surface and the second interior surface of the chamber and to define at least one reservoir space for the placement of cells within the chamber.
    Type: Application
    Filed: November 7, 2017
    Publication date: May 10, 2018
    Inventors: Edward H. Cully, Bernadette Parsons, Lauren Zambotti, Paul D. Drumheller
  • Publication number: 20180126133
    Abstract: An implantable containment apparatus for receiving and retaining a biological moiety or a therapeutic device within a tissue bed is disclosed. The device includes a shaping element to maintain the device in a generally toroidal configuration and to return the apparatus to that configuration after deformation. The apparatus can be placed in a host tissue with minimal trauma to the patient. Methods for implanting and using the apparatus are also disclosed.
    Type: Application
    Filed: November 7, 2017
    Publication date: May 10, 2018
    Inventors: Edward H. Cully, Paul D. Drumheller, Jeffrey B. Duncan, Nathan Friedman
  • Publication number: 20170360991
    Abstract: According to the invention there is provided inter alfa a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization.
    Type: Application
    Filed: March 13, 2015
    Publication date: December 21, 2017
    Inventors: Robert L. Cleek, Paul D. DRUMHELLER, Theresa A. HOLLAND, Todd J. JOHNSON
  • Patent number: 9731017
    Abstract: The present disclosure is directed to a class of fluorinated copolymers, such as a PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: August 15, 2017
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Paul D. Drumheller, Theresa A. Holland
  • Publication number: 20170072116
    Abstract: According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.
    Type: Application
    Filed: September 14, 2016
    Publication date: March 16, 2017
    Inventors: Per Antoni, Karin Leontein, Mei Li, Robert L. Cleek, Paul D. Drumheller
  • Publication number: 20170014553
    Abstract: According to the invention there is provided inter alia an implantable medical device with coatings comprising an immobilized heparin moiety and elutable paclitaxel and to methods for making such devices.
    Type: Application
    Filed: March 13, 2015
    Publication date: January 19, 2017
    Inventors: Per Antoni, Karin LEONTEIN, Lars VINCENT, Robert L. Cleek, Paul D. DRUMHELLER, Theresa A. HOLLAND, Todd J. JOHNSON, Krzysztof R. PIETRZAK, Bruce STEINHAUS
  • Publication number: 20160355688
    Abstract: Coatings for a surface, especially a priming coating, of the present invention have been found to be durable, resistant to oxidative degradation, erosion and depolymerisation, stable to sterilization and low particulating, and are easily applied to the required surface of a substrate in a surface-independent manner. Such coatings, when used as priming coatings to be coated with a subsequent coating, in at least some embodiments, form exterior coatings which are also highly durable and are stable to sterilisation and aging.
    Type: Application
    Filed: August 23, 2016
    Publication date: December 8, 2016
    Inventors: Paul D. Drumheller, Charles D. Claude
  • Patent number: 9447304
    Abstract: Coatings for a surface, especially a priming coating, of the present invention have been found to be durable, resistant to oxidative degradation, erosion and depolymerization, stable to sterilization and low particulating, and are easily applied to the required surface of a substrate in a surface-independent manner. Such coatings, when used as priming coatings to be coated with a subsequent coating, in at least some embodiments, form exterior coatings which are also highly durable and are stable to sterilization and aging.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 20, 2016
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Paul D. Drumheller, Charles D. Claude
  • Patent number: 9415193
    Abstract: The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: August 16, 2016
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Carey V. Campbell, Robert L. Cleek, Daniel L. Crandall, James F. Davidson, Paul D. Drumheller, Cody L. Hartman, Theresa A. Holland, Thane L. Kranzler, Mei Li, Gregory LoStracco, Bruce M. Steinhaus, Benjamin M. Trapp, Thomas G. Triebes
  • Publication number: 20160032145
    Abstract: Coatings for a surface, especially a priming coating, of the present invention have been found to be durable, resistant to oxidative degradation, erosion and depolymerisation, stable to sterilization and low particulating, and are easily applied to the required surface of a substrate in a surface-independent manner. Such coatings, when used as priming coatings to be coated with a subsequent coating, in at least some embodiments, form exterior coatings which are also highly durable and are stable to sterilisation and aging.
    Type: Application
    Filed: October 12, 2015
    Publication date: February 4, 2016
    Inventors: Paul D. Drumheller, Charles D. Claude
  • Publication number: 20160015868
    Abstract: According to the invention there is provided inter alia a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 21, 2016
    Inventors: Paul D. Drumheller, Robert L. Cleek, Todd J. Johnson, Theresa A. Holland
  • Publication number: 20160015870
    Abstract: According to the invention there is provided inter alia a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 21, 2016
    Inventors: Paul D. Drumheller, Robert L. Cleek, Todd J. Johnson, Theresa A. Holland
  • Publication number: 20160000977
    Abstract: According to the invention there is provided inter alia a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: Paul D. Drumheller, Robert L. Cleek, Todd J. Johnson, Theresa A. Holland