Patents by Inventor Paul E. Ashworth
Paul E. Ashworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10314694Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.Type: GrantFiled: March 24, 2017Date of Patent: June 11, 2019Assignee: St. Jude Medical, LLCInventors: Peter N. Braido, Paul E. Ashworth, Julia Schraut
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Publication number: 20190117841Abstract: Methods of preparing biological tissue for bioprosthetic valves include providing fresh biological tissue; treating the tissue with an aqueous cellulose solution for a time sufficient to allow the fluid in the tissue to be replaced by the aqueous cellulose solution; and cross-linking the tissue, wherein the treating step is performed prior to, during, after, or both prior to and after the cross-linking step. The methods may include storing the cellulose-treated and cross-linked tissue in an aqueous solution; or drying the cellulose-treated and cross-linked tissue by a vacuum-drying or lyophilization process, and storing the dried tissue in a dry, ambient environment. The treated tissue may be in the form of a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.Type: ApplicationFiled: April 28, 2017Publication date: April 25, 2019Applicant: St. Jude Medical, Cardiology Division, Inc.Inventor: Paul E. Ashworth
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Publication number: 20190001023Abstract: Methods of preparing calcification-resistant bioprosthetic tissue include providing fresh biological tissue, cross-linking the tissue, treating the cross-linked tissue with an alcohol for a time sufficient to allow the alcohol to be diffused into the tissue, and treating the alcohol-treated fixed tissue with a polyol for a time sufficient to allow fluid in the tissue to be replaced by the polyol. The methods may include sterilizing the cross-linked tissue in a solution including propylene oxide or peracetic acid either before or after the alcohol treatment step; or drying the alcohol/polyol-treated, cross-linked tissue, sterilizing the dried tissue by exposure to ethylene oxide or peracetic acid, and storing the sterilized tissue in a dry, ambient environment. The treated tissue may be a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.Type: ApplicationFiled: June 29, 2018Publication date: January 3, 2019Applicant: St. Jude Medical, Cardiology Division, Inc.Inventors: Paul E. Ashworth, Chad Joshua Green, Jay Reimer, Katherine A. Ahmann, David A. Panus
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Publication number: 20180246094Abstract: Methods of preparing a solid reference material so as to elicit a positive control response when tested for in-vitro complement activation include providing biological tissue; treating the tissue with an aqueous cellulose solution for a time sufficient to allow fluid in the tissue to be replaced by the aqueous cellulose solution; drying the cellulose-treated tissue by a vacuum-drying process or a lyophilization process to form dried tissue; and storing the dried tissue in a dry, ambient environment. The tissue prepared by these methods and its use in an in-vitro complement assay and diagnostic kit are also described.Type: ApplicationFiled: February 27, 2018Publication date: August 30, 2018Applicant: St. Jude Medical, Cardiology Division, Inc.Inventor: Paul E. Ashworth
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Patent number: 10010413Abstract: A method of making a prosthetic heart valve may include providing an annular stent having a plurality of annularly spaced commissure portions having tips, covering each of the tips with a first fabric cover, covering the first fabric covers and the remainder of the stent with a second fabric cover, covering the second fabric cover with a first tissue membrane, and covering the outside of the first tissue membrane with a second tissue membrane, the second tissue membrane forming leaflet portions that extend inwardly between the commissure portions.Type: GrantFiled: November 21, 2016Date of Patent: July 3, 2018Assignee: St. Jude Medical, LLCInventors: Chad Cai, Peter N. Braido, Bob Allan, Paul E. Ashworth, Steven D. Kruse, Lise LaChance
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Publication number: 20180042555Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.Type: ApplicationFiled: October 6, 2017Publication date: February 15, 2018Applicant: St. Jude Medical, Cardiology Division, Inc.Inventors: Peter N. Braido, Mina S. Fahim, Steven Frederick Anderl, Jason White, Paul E. Ashworth, Morgan Low, Loell Boyce Moon, Neelakantan Saikrishnan
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Patent number: 9808201Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.Type: GrantFiled: August 13, 2015Date of Patent: November 7, 2017Assignee: St. Jude Medical, Cardiology Division, Inc.Inventors: Peter N. Braido, Mina S. Fahim, Steven Frederick Anderl, Jason White, Paul E. Ashworth, Morgan Low, Loell Boyce Moon, Neelakantan Saikrishnan
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Publication number: 20170196687Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.Type: ApplicationFiled: March 24, 2017Publication date: July 13, 2017Applicant: St. Jude Medical, LLCInventors: Peter N. Braido, Paul E. Ashworth, Julia Schraut
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Patent number: 9681949Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.Type: GrantFiled: May 5, 2016Date of Patent: June 20, 2017Assignee: St. Jude Medical, LLCInventors: Peter N. Braido, Paul E. Ashworth, Julia A. Schraut
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Publication number: 20170065413Abstract: A method of making a prosthetic heart valve may include providing an annular stent having a plurality of annularly spaced commissure portions having tips, covering each of the tips with a first fabric cover, covering the first fabric covers and the remainder of the stent with a second fabric cover, covering the second fabric cover with a first tissue membrane, and covering the outside of the first tissue membrane with a second tissue membrane, the second tissue membrane forming leaflet portions that extend inwardly between the commissure portions.Type: ApplicationFiled: November 21, 2016Publication date: March 9, 2017Applicant: St. Jude Medical, Inc.Inventors: Chad Cai, Peter N. Braido, Bob Allan, Paul E. Ashworth, Steven D. Kruse, Lise LaChance
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Patent number: 9510944Abstract: A method of making a prosthetic heart valve may include providing an annular stent having a plurality of annularly spaced commissure portions having tips, covering each of the tips with a first fabric cover, covering the first fabric covers and the remainder of the stent with a second fabric cover, covering the second fabric cover with a first tissue membrane, and covering the outside of the first tissue membrane with a second tissue membrane, the second tissue membrane forming leaflet portions that extend inwardly between the commissure portions.Type: GrantFiled: October 15, 2015Date of Patent: December 6, 2016Assignee: St. Jude Medical, Inc.Inventors: Chad Cai, Peter N. Braido, Bob Allan, Paul E. Ashworth, Steven D. Kruse, Lise LaChance
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Publication number: 20160242904Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.Type: ApplicationFiled: May 5, 2016Publication date: August 25, 2016Inventors: Peter N. Braido, Paul E. Ashworth, Julia A. Schraut
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Publication number: 20160045165Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.Type: ApplicationFiled: August 13, 2015Publication date: February 18, 2016Inventors: Peter N. Braido, Mina S. Fahim, Steven Frederick Anderl, Jason White, Paul E. Ashworth, Morgan Low, Loell Boyce Moon, Neelakantan Saikrishnan
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Publication number: 20160045316Abstract: A prosthetic device for implanting in a patient's heart includes (i) a therapeutic device capable of restoring function to a native heart valve; and (ii) at least one sensor including a body, an inductor coil disposed within the body, and a capacitor in communication with the inductor coil, the at least one sensor being coupled to the therapeutic device, and being configured to monitor proper function of the therapeutic device within the patient's heart.Type: ApplicationFiled: August 13, 2015Publication date: February 18, 2016Applicant: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.Inventors: Peter N. Braido, Mina S. Fahim, Loell Boyce Moon, Paul E. Ashworth, Neelakantan Saikrishnan, Steven Frederick Anderl
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Publication number: 20160030173Abstract: A method of making a prosthetic heart valve may include providing an annular stent having a plurality of annularly spaced commissure portions having tips, covering each of the tips with a first fabric cover, covering the first fabric covers and the remainder of the stent with a second fabric cover, covering the second fabric cover with a first tissue membrane, and covering the outside of the first tissue membrane with a second tissue membrane, the second tissue membrane forming leaflet portions that extend inwardly between the commissure portions.Type: ApplicationFiled: October 15, 2015Publication date: February 4, 2016Applicant: St. Jude Medical, Inc.Inventors: Chad Cai, Peter N. Braido, Bob Allan, Paul E. Ashworth, Steven D. Kruse, Lise LaChance
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Patent number: 8808356Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.Type: GrantFiled: July 15, 2009Date of Patent: August 19, 2014Assignee: St. Jude Medical, Inc.Inventors: Peter N. Braido, Paul E. Ashworth, Julia A. Neuman
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Publication number: 20110098802Abstract: A prosthetic heart valve is provided with a cuff (85, 285, 400) having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion (90) adapted to bear native aortic valve. The valve may include elements (210, 211, 230, 252, 253) for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness (280) distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part (402) of the cuff may be movable relative to the stent during implantation.Type: ApplicationFiled: July 15, 2009Publication date: April 28, 2011Inventors: Peter N. Braido, Paul E. Ashworth, Julia A. Neuman