Patents by Inventor Paul-Eberhard Schulze

Paul-Eberhard Schulze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5124267
    Abstract: The invention relates to a process for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material, characterized by either binding the compound to be determined and its deuterated analog to an antibody present in excess, which antibody is coupled to a stationary phase of a polymeric material, and separating the two compounds from the antibody and measuring by mass spectrometry the proportion of deuterated compound/not deuterated compound or, respectively, cross-reacting compound; or, in case a suitable deuterated or cross-reacting compound is not available, utilizing as the internal standard also a chemically similar compound which, however, is added after the antibody-mediated extraction, and inserting a separating process before mass spectrometry.
    Type: Grant
    Filed: January 10, 1986
    Date of Patent: June 23, 1992
    Assignee: Schering Aktiengesellschaft
    Inventors: Michael Humpel, Werner Krause, Paul-Eberhard Schulze, Bob Nieuweboer
  • Patent number: 4904462
    Abstract: Novel, multiple-tritiated steroid-20,17-spirolactones of general Formula I ##STR1## wherein --A--B-- is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or ##STR2## and --C--D-- is ##STR3## R is hydrogen or tritium and n is 0 or 1,are usable as tracer materials for the detection of mineralocorticoid receptors.
    Type: Grant
    Filed: April 12, 1985
    Date of Patent: February 27, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Paul-Eberhard Schulze, Klaus Nickisch, Henry Laurent, Kunhard Pollow
  • Patent number: 4857298
    Abstract: Compounds of general Formula I labeled with .sup.121 I, .sup.122 I, .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I and .sup.132 I isotopes ##STR1## wherein R.sup.6 is a C.sub.1-6 aliphatic hydrocarbon residue andC.sub.2 -C.sub.3 C.sub.9 -C.sub.10 is a single or a double bond, as well as their acid addition salts,are useful as diagnostic media, e.g., in imaging dopamine and other receptors.
    Type: Grant
    Filed: July 10, 1987
    Date of Patent: August 15, 1989
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Wachtel, Herbert H. Schneider, Peter-Andreas Loschmann, Rainer Dorow, Reinhard Horowski, Bernard Acksteiner, Paul-Eberhard Schulze, Gerhard Sauer
  • Patent number: 4794119
    Abstract: An aqueous crystalline suspension of a 17-tertiary steroid glycoester contains a compound of Formula I ##STR1## wherein X is two hydrogen atoms or an oxygen atom,Y is two hydrogen atoms or a methylene group,R.sup.1 is hydrogen or methyl,Z is hydroxy or --O--CO--R.sup.2R.sup.2 is methyl or phenyl, and ##STR2## in the following fractions: 0-30% by weight of a particle size of 3-15 .mu.m,40-90% by weight of a particle size of 15-60 .mu.m, and20-60% by weight of a particle size of 30-100 .mu.m.Upon a one-time intramuscular injection of 30-75 mg of steroid glycoester as an aqueous crystalline suspension, a steroid level is achieved in the plasma which, over a period of 4 weeks, is adequately high and shows a uniform course.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: December 27, 1988
    Assignee: Schering Aktiengesellschaft
    Inventors: Paul-Eberhard Schulze, Bernard Acksteiner, Bernd Dusterberg
  • Patent number: 4780460
    Abstract: Glycoesters of estradiol (E.sub.2) and of estriol (E.sub.3) of Formula I(E.sub.2,3)--O--CO--CH.sub.2 --Z (I)whereinZ is hydroxy or the group --O--CO--R whereinR is methyl or phenyl,provide a uniform and enduring estrogen level especially when used in the form of an aqueous crystalline suspension.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: October 25, 1988
    Assignee: Schering Aktiengesellschaft
    Inventors: Bernd Dusterlerg, Bernard Acksteiner, Paul-Eberhard Schulze
  • Patent number: 4367216
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydroxy-C.sub.2-8 -alkyl containing 1-5 OH-groups;R.sup.2 is hydrogen, C.sub.1-4 -alkyl or R.sup.1 ;R.sup.3 and R.sup.4 can be identical or different, and each independently is hydrogen or C.sub.1-4 -alkyl; andX is straight chain or branched C.sub.2-12 alkylene interrupted by sulfur or selenium atoms, and, optionally, additionally interrupted by oxygen atoms, by a di(C.sub.1-4 -alkyl)silyl group or a tetra(C.sub.1-4 -alkyl)disiloxane group;are very useful as X-ray contrast media opaque agents, which can be employed even in lymphography.
    Type: Grant
    Filed: June 27, 1980
    Date of Patent: January 4, 1983
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Mutzel, Hans-Martin Siefert, Ulrich Speck, Heinrich Pfeiffer, Paul-Eberhard Schulze, Bernhard Acksteiner
  • Patent number: 4315866
    Abstract: A process for preparing an 11-keto steroid consists essentially of heating the corresponding 9.alpha.-halo-11.beta.-hydroxy steroid, to 180.degree.-350.degree. C. in an inert, aprotic, high-boiling solvent.
    Type: Grant
    Filed: December 10, 1980
    Date of Patent: February 16, 1982
    Assignee: Schering, A.G.
    Inventors: Paul-Eberhard Schulze, Ulrich Kerb
  • Patent number: 4290963
    Abstract: A process for preparing a .DELTA..sup.9(11) - and/or .DELTA..sup.16 -unsaturated steroid comprises heating the corresponding steroid of the pregnane series substituted by 9.alpha.-chloro- and/or 16.alpha.-chloro- or 17.alpha.-acyloxy, in an inert, aprotic high-boiling solvent at 180.degree.-350.degree. C.
    Type: Grant
    Filed: July 18, 1980
    Date of Patent: September 22, 1981
    Assignee: Schering Aktiengesellschaft
    Inventors: Paul-Eberhard Schulze, Ulrich Kerb
  • Patent number: 3933869
    Abstract: Organic radiohalogen compounds are prepared by heating in a non-aqueous liquid phase a mixture of a radioinactive organic halogen compound and an alkali metal halogenide or alkaline earth halogenide wherein the halogenide is F-18, Cl-38, Br-82 or I-123, -125, -131 or -132.
    Type: Grant
    Filed: December 5, 1973
    Date of Patent: January 20, 1976
    Assignee: Schering Aktiengesellschaft
    Inventor: Paul-Eberhard Schulze