Patents by Inventor Paul Fisher

Paul Fisher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050250127
    Abstract: The present invention relates to the discoveries that apoptotic effects of the melanoma differentiation associated gene mda-7 (also known as interleukin-24, “IL-24”) on malignant cells occur via the p38 MAPK pathway and members of the Growth Arrest and DNA Damage (“GADD”) gene family but are substantially independent of the JAK/STAT pathway. Accordingly, the invention provides for methods for identifying apoptosis-modulating agents using assay methods which determine the ability of a test agent to increase or decrease expression of constituents of the mda-7 apoptosis pathway, preferably in a JAK/STAT substantially independent manner. Such agents may be small molecules or may be fragments, variants and/or derivatives of native MDA-7.
    Type: Application
    Filed: December 22, 2004
    Publication date: November 10, 2005
    Inventors: Paul Fisher, Devanand Sarkar, Rahul Gopalkrishnan, Moira Sauane
  • Publication number: 20050250206
    Abstract: This invention provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein which expresses on the surface of one cell type but not the other. This invention also provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein. This invention provides a method to prepare a hybridoma cell line which specifically recognizes and binds to a tumor associated antigen associated with a neoplastic, human cell. This invention also provides a method of preparing DNA encoding a cell surface antigen associated with a neoplastic, human cell. This invention further provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Carcinoma Tumor Antigen Gene-1. This invention also provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Tumor Inducing Gene-1.
    Type: Application
    Filed: April 20, 2004
    Publication date: November 10, 2005
    Inventor: Paul Fisher
  • Patent number: 6939781
    Abstract: In one embodiment of the invention, a semiconductor component includes a semiconductor substrate (110), a first dielectric layer (120) above the semiconductor substrate, a first ohmic contact region (410) and a second ohmic contact region (420) above the semiconductor substrate, a gate electrode (1120) above the semiconductor substrate and between the first ohmic contact region and the second ohmic contact region, a field plate (210) above the first dielectric layer and between the gate electrode and the second ohmic contact region, a second dielectric layer (310) above the field plate, the first dielectric layer, the first ohmic contact region, and the second ohmic contact region, and a third dielectric layer (910) between the gate electrode and the field plate and not located above the gate electrode or the field plate.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: September 6, 2005
    Assignee: Freescale Semiconductor, Inc.
    Inventors: Randy D. Redd, Paul A. Fisher, Olin L. Hartin, Lawrence S. Klingbeil, Ellen Lan, Hsin-Hua P. Li, Charles E. Weitzel
  • Publication number: 20050191277
    Abstract: This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under conditions that permit the expression of the gene so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a method for reversing the cancerous phenotype of a cancer cell by introducing the gene product of the above-described gene into the cancerous cell so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a pharmaceutical composition having the melanoma differentiation associated gene (mda-7) or the gene product of the melanoma differentiation associated gene (mda-7) effective to reverse the cancerous phenotype of a cancer cell and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: January 31, 2005
    Publication date: September 1, 2005
    Inventor: Paul Fisher
  • Publication number: 20050187871
    Abstract: The invention relates to a method for electronically furthering the commodity operations for a particular unit of a commodity on a distributed computer network such that a data record indicating the identity of the electronic title holder can be securely updated by actors in the commodity exchange, or automatically by the system. In addition, the present invention relates to a method for securely indicating the collateralized status of a commodity, while simultaneously facilitating the transfer of the commodity from a first party to a third party such that the collateralization of the commodity is not jeopardized.
    Type: Application
    Filed: March 1, 2005
    Publication date: August 25, 2005
    Inventors: Nancy Yeung, Paul Fisher
  • Publication number: 20050186211
    Abstract: The present invention relates to mda-5 nucleic acids, MDA-5 proteins, the mda-5 promoter, and related molecules, and the use of each of these elements in protecting against or limiting viral infection, controlling cell proliferation, and promoting apoptosis. It is based upon the discovery that, contrary to earlier hypotheses based on the amino acid sequence of MDA-5, the protein is not a defective ATPase but rather exhibits ATPase activity. This supports the role of MDA-5 as a RNA helicase protein and consequently its use in promoting RNA degradation, for example in the context of antiviral defense, limitation of cell proliferation, or induction of apoptosis.
    Type: Application
    Filed: January 24, 2005
    Publication date: August 25, 2005
    Inventors: Paul Fisher, Dong-Chul Kang, Rahul Gopalkrishnan
  • Publication number: 20050179413
    Abstract: The present invention provides a system for controlling the speed of a motor by altering the magnetic field of the motor. The system includes field modification module, and a motor having field windings and a rotor. The field windings are configured to receive a driving signal that generates a magnetic field causing a rotation of the rotor. The field modification module is proximate the motor and alters the magnetic field in response to an input signal thereby controlling the speed and torque of the rotor.
    Type: Application
    Filed: February 17, 2004
    Publication date: August 18, 2005
    Inventors: Harold Castle, DeQuan Yu, Stephen Kempfer, Norman Krieger, Paul Fisher, Sheven Sharp, James Thompson
  • Publication number: 20050173149
    Abstract: In order to provide a flexible oxide superconducting cable which is reduced in AC loss, tape-shaped superconducting wires covered with a stabilizing metal are wound on a flexible former. The superconducting wires are preferably laid on the former at a bending strain of not more than 0.2%. In laying on the former, a number of tape-shaped superconducting wires are laid on a core member in a side-by-side manner, to form a first layer. A prescribed number of tape-shaped superconducting wires are laid on top of the first layer in a side-by-side manner, to form a second layer. The former may be made of a metal, plastic, reinforced plastic, polymer, or a composite and provides flexibility to the superconducting wires and the cable formed therewith. Methods of forming and terminating a triaxial superconductor are disclosed.
    Type: Application
    Filed: August 1, 2003
    Publication date: August 11, 2005
    Inventors: Michael Gouge, Paul Fisher, C.A. Foster, M.J. Cole, David Lindsay
  • Publication number: 20050172343
    Abstract: The present invention relates to Astrocyte Modulated Genes (AMGs). AMGs are genes whose expression are modulated in human astrocytes grown in primary cell culture following the exposure of these cells to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. AMGs comprise both Astrocyte Enhanced Genes (AEGs) and Astrocyte Suppressed Genes (ASGs). Thus, the present invention further relates to Astrocyte Enhanced Genes (AEGs), the expression of which are up-regulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120, and to Astrocyte Suppressed Genes (ASGs), the expression of which are downregulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. Because they may play a role in HIV-associated dementia (“HAD”), AMGs may be used as markers in methods for screening for drugs that treat or prevent HAD.
    Type: Application
    Filed: October 27, 2004
    Publication date: August 4, 2005
    Inventors: Paul Fisher, Zhao-zhong Su, Dong-chul Kang
  • Publication number: 20050163709
    Abstract: This invention provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein which expresses on the surface of one cell type but not the other. This invention also provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein. This invention provides a method to prepare a hybridoma cell line which specifically recognizes and binds to a tumor associated antigen associated with a neoplastic, human cell. This invention also provides a method of preparing DNA encoding a cell surface antigen associated with a neoplastic, human cell. This invention further provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Carcinoma Tumor Antigen Gene-1. This invention also provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Tumor Inducing Gene-1.
    Type: Application
    Filed: September 30, 2004
    Publication date: July 28, 2005
    Inventors: Paul Fisher, Ruoquian Shen
  • Publication number: 20050154479
    Abstract: Many variables in processes such as those using turbocompressors and turbines must be limited or constrained. Limit control loops are provided for the purpose of limiting these variables. By using a combination of closed loop and open loop limit control schemes, excursions into unfavorable operation can be more effectively avoided. Transition between open loop and closed loop may be enhanced by testing the direction and magnitude of the rate at which the limit variable is changing. If the rate of change indicates recovery is imminent, control is passed back to the closed loop limit control function.
    Type: Application
    Filed: January 13, 2004
    Publication date: July 14, 2005
    Inventors: Krishnan Narayanan, Paul Fisher
  • Publication number: 20050113323
    Abstract: This invention provides a method for reversing cancer phenotype of a cancer cell which comprises introducing an exogenous material which is capable of specifically recognizing either a Prostate Tumor Inducing Gene, RNA of said gene or gene product of said gene into the cell under conditions permitting inhibition of the expression of said gene or function of said gene product so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a method for reversing cancer phenotype of a cancer cell in a subject which comprises introducing an exogenous material which is capable of specifically recognizing a Prostate Tumor Inducing Gene, RNA of said gene or gene product of said gene into the subject's cancer cell under conditions permitting inhibition of the expression of said gene or function of said gene product in the subject's cell so as to thereby reverse the cancerous phenotype of the cell.
    Type: Application
    Filed: January 12, 2004
    Publication date: May 26, 2005
    Inventor: Paul Fisher
  • Publication number: 20040262629
    Abstract: In one embodiment of the invention, a semiconductor component includes a semiconductor substrate (110), a first dielectric layer (120) above the semiconductor substrate, a first ohmic contact region (410) and a second ohmic contact region (420) above the semiconductor substrate, a gate electrode (1120) above the semiconductor substrate and between the first ohmic contact region and the second ohmic contact region, a field plate (210) above the first dielectric layer and between the gate electrode and the second ohmic contact region, a second dielectric layer (310) above the field plate, the first dielectric layer, the first ohmic contact region, and the second ohmic contact region, and a third dielectric layer (910) between the gate electrode and the field plate and not located above the gate electrode or the field plate.
    Type: Application
    Filed: June 27, 2003
    Publication date: December 30, 2004
    Applicant: Motorola, Inc.
    Inventors: Randy D. Redd, Paul A. Fisher, Olin L. Hartin, Lawrence S. Klingbeil, Ellen Lan, Hsin-Hua P. Li, Charles E. Weitzel
  • Patent number: 6753258
    Abstract: A method and apparatus for processing a substrate to form a feature in low k dielectric materials. One aspect of the invention provides a method for processing a substrate including forming a feature definition in a dielectric material deposited on a surface of a substrate, depositing one or more conductive materials to fill at least a portion of the feature definition, planarizing the substrate surface to expose the dielectric material, removing at least a portion of the dielectric material, and depositing a low k dielectric material.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: June 22, 2004
    Assignee: Applied Materials Inc.
    Inventors: Frederic Gaillard, Li-Qun Xia, Ellie Yieh, Paul Fisher, Margaret Gotuaco
  • Patent number: 6750141
    Abstract: A method of forming a low dielectric constant silicate material for use in integrated circuit fabrication processes is disclosed. The low dielectric constant silicate material is formed by reacting by reacting a gas mixture comprising an organosilane compound, an oxygen source, and an inert gas. Thereafter, a silicon carbide cap layer is formed on the silicate material by reacting a gas mixture comprising a silicon source and a carbon source. The silicon carbide cap layer protects the underlying organosilicate layer from cracking and peeling when it is hardened during a subsequent annealing step.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: June 15, 2004
    Assignee: Applied Materials Inc.
    Inventors: Li-Qun Xia, Paul Fisher, Margaret Lynn Gotuaco, Frederic Gaillard, Ellie Yieh
  • Patent number: 6739844
    Abstract: A vehicle regenerative-type fuel pump which reduces the possible accumulation and effects of contamination relative to impellers with outer ring members. The outlet port on the pump cover member is enlarged and the C-shaped grove is positioned radially outwardly, which causes an increased outlet area and fluid flow around and through the impeller and through the outlet port.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: May 25, 2004
    Assignee: Visteon Global Technologies, Inc.
    Inventors: DeQuan Yu, Paul Fisher
  • Patent number: 6621451
    Abstract: A radar display system (10) according to the present invention generates textured radar display data by utilizing a direct memory access receiver (12) to receive radially scanned radar data, to convert the radially scanned radar data into range bin data sets, and to store the range bin data sets. A graphics renderer (18) stores the set of range bin data sets in a texture memory (20) as a plurality of rectangular textures, and bit maps the rectangular textures to a series of display triangles in a frame buffer (22). The graphics renderer (18) colors the display triangles in accordance with the rectangular textures by performing a bi-linear interpolation of the color and warps the display triangles in accordance with the size of a display (24).
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: September 16, 2003
    Assignee: Honeywell International Inc.
    Inventors: Paul A. Fisher, William R. Hancock, Susan L. McCullough
  • Patent number: 6604905
    Abstract: A vehicle regenerative-type fuel pump which reduces the possible accumulation and effects of contamination relative to impellers with outer ring members. The outer ring members have non-uniform configurations (slanted, curved, grooved, etc.) which reduce the affects of contamination which can cause wear and roughing of the outer surface resulting in higher torque and reduced pump efficiencies.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: August 12, 2003
    Assignee: Visteon Global Technologies, Inc.
    Inventors: DeQuan Yu, Paul Fisher
  • Patent number: 6561765
    Abstract: A vehicle regenerative-type fuel pump which reduces the possible accumulation and effects of contamination relative to impellers with outer ring members. The impellers for the pump have outer ring members with non-uniform configurations (slanted, curved, grooved, etc.) which reduce the affects of contamination which can cause wear and roughing of the outer surface resulting in higher torque and reduced pump efficiencies.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: May 13, 2003
    Inventors: DeQuan Yu, Paul Fisher
  • Patent number: 6531398
    Abstract: A method of forming an organosilicate layer is disclosed. The organosilicate layer is formed by applying an electric field to a gas mixture comprising an organosilane compound and an oxygen-containing gas. The organosilicate layer is compatible with integrated circuit fabrication processes. In one integrated circuit fabrication process, the organosilicate layer is used as an intermetal dielectric layer. In another integrated circuit fabrication process, the organosilicate layer is incorporated into a damascene structure.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: March 11, 2003
    Assignee: Applied Materials, Inc.
    Inventors: Frederic Gaillard, Li-Qun Xia, Ellie Yieh, Paul Fisher, Srinivas D. Nemani