Patents by Inventor Paul G. Ahlquist
Paul G. Ahlquist has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11058699Abstract: A method of inhibiting double-stranded DNA virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors. In another embodiment, the method involves administering an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors to a susceptible tissue or cell.Type: GrantFiled: June 29, 2009Date of Patent: July 13, 2021Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Paul F. Lambert, Shane Pearce, Paul G. Ahlquist, Dohun Pyeon
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Patent number: 9949980Abstract: A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.Type: GrantFiled: June 2, 2015Date of Patent: April 24, 2018Assignee: Wisconsin Alumni Research FoundationInventors: Paul F. Lambert, Paul G. Ahlquist, Dohun Pyeon, Hao Shun Huang
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Patent number: 9790553Abstract: Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.Type: GrantFiled: July 29, 2011Date of Patent: October 17, 2017Assignee: Wisconsin Alumni Research FoundationInventors: Dohun Pyeon, Paul F. Lambert, Michael A. Newton, Paul G. Ahlquist
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Publication number: 20150297602Abstract: A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.Type: ApplicationFiled: June 2, 2015Publication date: October 22, 2015Inventors: Paul F. Lambert, Paul G. Ahlquist, Dohun Pyeon, Hao Shun Huang
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Patent number: 9066951Abstract: A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.Type: GrantFiled: May 29, 2009Date of Patent: June 30, 2015Assignee: Wisconsin Alumni Research FoundationInventors: Paul F. Lambert, Paul G. Ahlquist, Dohun Pyeon, Hao Shun Huang
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Publication number: 20110301059Abstract: Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.Type: ApplicationFiled: July 29, 2011Publication date: December 8, 2011Inventors: DOHUN PYEON, PAUL F. LAMBERT, MICHAEL A. NEWTON, PAUL G. AHLQUIST
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Patent number: 8012678Abstract: Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.Type: GrantFiled: July 24, 2008Date of Patent: September 6, 2011Assignee: Wisconsin Alumni Research FoundationInventors: Dohun Pyeon, Paul F. Lambert, Michael A. Newton, Paul G. Ahlquist
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Publication number: 20110189258Abstract: A method of inhibiting double-stranded DNA virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors. In another embodiment, the method involves administering an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors to a susceptible tissue or cell.Type: ApplicationFiled: June 29, 2009Publication date: August 4, 2011Inventors: Dohun Pyeon, Paul F. Lambert, Shane Pearce, Paul G. Ahlquist
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Publication number: 20110165220Abstract: A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.Type: ApplicationFiled: May 29, 2009Publication date: July 7, 2011Inventors: Paul F. Lambert, Paul G. Ahlquist, Dohun Pyeon, Hao Shun Huang
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Publication number: 20110165266Abstract: A method of screening test chemicals or compounds as inhibitors of HIV replication is disclosed. In one embodiment, the method comprises the step of determining whether the test chemical or compound is a sulfonation inhibitor. In another embodiment, the invention is a method of treating an HIV infected individual to reduce HIV replication comprising the step of treating the individual with an effective amount of sulfonation inhibitor.Type: ApplicationFiled: April 30, 2009Publication date: July 7, 2011Inventors: James W. Bruce, Paul G. Ahlquist, John A.T. Young
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Publication number: 20100047838Abstract: An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus resistant organism comprising creating a transgenic organism comprising an antiviral agent selected from the group of altered MAB1 genes, MAB2 genes, MAB3 genes or OLE1 genes, homologs of these genes, related genes and combinations of these genes and homologs.Type: ApplicationFiled: September 21, 2009Publication date: February 25, 2010Applicant: Wisconsin Alumni Research FoundationInventors: Paul G. Ahlquist, Masayuki Ishikawa, Juana Diez, Duane B. Price, Wai-Ming Lee
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Patent number: 7611833Abstract: An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus resistant organism comprising creating a transgenic organism comprising an antiviral agent selected from the group of altered MAB1 genes, MAB2 genes, MAB3 genes or OLE1 genes, homologs of these genes, related genes and combinations of these genes and homologs.Type: GrantFiled: July 14, 2003Date of Patent: November 3, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Paul G. Ahlquist, Masayuki Ishikawa, Juana Diez, Duane B. Price, Wai-Ming Lee
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Patent number: 7563597Abstract: A method of producing a packaged DNA sequence is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a DNA sequence to be packaged and a papillomaviral capsid sequence, wherein the DNA sequence to be packaged is between 7 Kb-8.5 Kb, (b) co-transfecting the products of step (a) into transfectable cells, wherein the DNA sequence is packaged, and (c) purifying packaged particles.Type: GrantFiled: January 30, 2006Date of Patent: July 21, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Paul G. Ahlquist, Dohun Pyeon, Paul F. Lambert
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Publication number: 20090148950Abstract: A method of producing a packaged DNA sequence is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a DNA sequence to be packaged and a papillomaviral capsid sequence, wherein the DNA sequence to be packaged is between 7 Kb-8.5 Kb, (b) co-transfecting the products of step (a) into transfectable cells, wherein the DNA sequence is packaged, and (c) purifying packaged particles.Type: ApplicationFiled: January 30, 2006Publication date: June 11, 2009Inventors: Paul G. Ahlquist, Dohun Pyeon, Paul F. Lambert
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Publication number: 20090136486Abstract: Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.Type: ApplicationFiled: July 24, 2008Publication date: May 28, 2009Inventors: Dohun Pyeon, Paul F. Lambert, Michael A. Newton, Paul G. Ahlquist
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Publication number: 20030082753Abstract: A method of synthesizing particles containing nucleic acid sequences is disclosed. This method comprises the steps of introducing a non-endogenous packageable nucleic acid sequence and a sequence encoding a suitable non-endogenous capsid protein into yeast cells and inducing particle assembly, wherein at least one nucleic acid is encapsidated. Preferably, the particle is an infectious virion and the method additionally comprises the step of inducing viral nucleic acid replication before particle assembly. A method of replicating an animal or Nodaviridae virus nucleic acid sequences in yeast is also disclosed.Type: ApplicationFiled: October 14, 2002Publication date: May 1, 2003Inventors: B. Duane Price, Roland R. Rueckert, Michael A. Krol, Paul G. Ahlquist
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Publication number: 20020072094Abstract: A method of synthesizing particles containing nucleic acid sequences is disclosed. This method comprises the steps of introducing a non-endogenous packageable nucleic acid sequence and a sequence encoding a suitable non-endogenous capsid protein into yeast cells and inducing particle assembly, wherein at least one nucleic acid is encapsidated. Preferably, the particle is an infectious virion and the method additionally comprises the step of inducing viral nucleic acid replication before particle assembly. A method of replicating an animal or Nodaviridae virus nucleic acid sequences in yeast is also disclosed.Type: ApplicationFiled: July 29, 1998Publication date: June 13, 2002Inventors: B. DUANE PRICE, ROLAND R. RUECKERT, MICHAEL A. KROL, PAUL G. AHLQUIST
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Publication number: 20020016305Abstract: An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus resistant organism comprising creating a transgenic organism comprising an antiviral agent selected from the group of altered MAB1 genes, MAB2 genes, MAB3 genes or OLE1 genes, homologs of these genes, related genes and combinations of these genes and homologs.Type: ApplicationFiled: January 12, 2001Publication date: February 7, 2002Inventors: Paul G. Ahlquist, Masayuki Ishikawa, Juana Diez, Duane B. Price, Wai-Ming Lee
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Patent number: 6291743Abstract: The invention involves production of transgenic plants containing DNA encoding AC1/C1 wildtype and mutant sequences that negatively interfere in trans with geminiviral replication during infection. The transgenic plants produced by the invention are resistant to viral infection.Type: GrantFiled: April 15, 1997Date of Patent: September 18, 2001Assignees: Seminis Vegetable Seeds, Inc., Wisconsin Alymni Research Foundation, Regents of the University of CaliforniaInventors: John T. Stout, Hang T. Luu, Steven F. Hanson, Douglas P. Maxwell, Paul G. Ahlquist, Robert L. Gilbertson
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Publication number: 20010011379Abstract: The invention involves production of transgenic plants containing DNA encoding AC1/C1 wildtype and mutant sequences that negatively interfere in trans with geminiviral replication during infection. The transgenic plants produced by the invention are resistant to viral infection.Type: ApplicationFiled: April 15, 1997Publication date: August 2, 2001Inventors: JOHN T. STOUT, HANG T. LUU, STEVEN F. HANSON, DOUGLAS P. MAXWELL, PAUL G. AHLQUIST, ROBERT L. GILBERTSON