Patents by Inventor Paul Graham Winyard

Paul Graham Winyard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use in photodynamic therapy
    Patent number: 10149907
    Abstract: The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: December 11, 2018
    Assignee: University of Exeter
    Inventors: Mark Elliott Wood, Paul Graham Winyard, Daniel Colin Jeremy Ferguson, Matthew Whiteman, Alison Curnow, Alexis Perry
  • COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR, THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN PHOTODYNAMIC THERAPY
    Publication number: 20180161430
    Abstract: The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.
    Type: Application
    Filed: February 7, 2018
    Publication date: June 14, 2018
    Inventors: Mark Elliott WOOD, Paul Graham WINYARD, Daniel Colin Jeremy FERGUSON, Matthew WHITEMAN, Alison CURNOW, Alexis PERRY
  • Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use in photodynamic therapy
    Patent number: 9919049
    Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: March 20, 2018
    Assignee: University of Exeter
    Inventors: Mark Elliott Wood, Paul Graham Winyard, Daniel Colin Jeremy Ferguson, Matthew Whiteman, Alison Curnow, Alexis Perry
  • COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR, THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN PHOTODYNAMIC THERAPY
    Publication number: 20170202966
    Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy
    Type: Application
    Filed: June 2, 2015
    Publication date: July 20, 2017
    Inventors: Mark Elliott WOOD, Paul Graham WINYARD, Daniel Colin Jeremy FERGUSON, Matthew WHITEMAN, Alison CURNOW, Alexis PERRY
  • AGRICULTURAL TREATMENT
    Publication number: 20100129474
    Abstract: A method for the control of microorganisms, fungi or oomycetes in agriculture, said method comprising applying to plants or to the environment thereof, an anti-microbial, anti-fungal or anti-oomycetes effective amount of a combination of: (i) an agriculturally acceptable acidifying agent, and (ii) an agriculturally acceptable source of nitrite ions or a nitrate precursor thereof, wherein the combination of (i) and (ii) acts as a source of nitric oxide. Systems and compositions for use in this method are also described and claimed.
    Type: Application
    Filed: September 24, 2007
    Publication date: May 27, 2010
    Applicant: UNIVERSITY OF EXETER
    Inventors: Nigel Benjamin, Nicholas Jose Talbot, Michael John Kershaw, Paul Graham Winyard
  • Nitroso compounds and their use as spin traps
    Patent number: 6767715
    Abstract: A compound of the formula wherein X is Cl or CH3, or a salt thereof, is useful as a spin trap in various assays.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: July 27, 2004
    Assignee: Randox Laboratories Ltd.
    Inventors: Lynne Hamilton, Paul Graham Winyard
  • Spin trap for use in biological systems
    Publication number: 20030109051
    Abstract: A spin-trapping assay for nitric oxide, in a biological system such as whole blood, uses as the spin trap a lipid-soluble nitrobenzene compound such as 2,6-dimethylnitrosobenzene.
    Type: Application
    Filed: October 15, 2002
    Publication date: June 12, 2003
    Applicant: RANDOX LABORATORIES LTD
    Inventors: Stephen Peter Fitzgerald, Lynne Hamilton, Paul Graham Winyard
  • Nitroso compounds and their use as spin traps
    Publication number: 20020086338
    Abstract: A compound of the formula 1
    Type: Application
    Filed: December 11, 2001
    Publication date: July 4, 2002
    Applicant: RANDOX LABORATORIES, LTD.
    Inventors: Lynne Hamilton, Paul Graham Winyard