Patents by Inventor Paul H. Dear

Paul H. Dear has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130102490
    Abstract: The present invention provides a method for counting the absolute copy number of a nucleic acid sequence in a cell, which comprises the following steps: (i) dividing a lysate of the cell or a lysate of a sample of the cell into a plurality aliquots: (ii) providing conditions suitable for the amplification of the nucleic acid sequence in each aliquot: (iii) counting the number of aliquots in which the nucleic acid was amplified in step (ii) and directly deducing the copy number of the nucleic acid sequence in a cell. The method may be used to count chromatid copy number, for example to investigate the ploidy of a cell such as an oocyte or an embryo-derived cell.
    Type: Application
    Filed: May 4, 2011
    Publication date: April 25, 2013
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Angelika H. Daser, Paul H. Dear
  • Publication number: 20110275068
    Abstract: The present invention relates to a combination method for A) measuring the copy number frequency of one or more nucleic acid sequences in a sample; and B) analysing the sequence of at least part of the nucleic acid sequence(s), wherein method A) comprises the steps of: (i) providing one or more (e.g.
    Type: Application
    Filed: May 10, 2010
    Publication date: November 10, 2011
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: PAUL H. DEAR, Frank McCaughan
  • Publication number: 20090191556
    Abstract: The present invention relates to a novel method for the delivery of agents to tumour cells. In particular it relates to a method for the specific delivery of agents to the interior of tumour cells. Uses of the method are also described.
    Type: Application
    Filed: April 12, 2007
    Publication date: July 30, 2009
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Madan Thangavelu, Paul H. Dear, Terence H. Rabbitts, Angelika Daser, Alan Thomas Bankier, Bernard Anri Konfortov
  • Publication number: 20040248153
    Abstract: The invention provides a method for analyzing a nucleic acid, comprising cleaving the nucleic acid into multiple fragments at a defined sequence, and selectively amplifying individual fragments to produce a map by a modified HAPPY mapping technique.
    Type: Application
    Filed: December 18, 2003
    Publication date: December 9, 2004
    Applicant: Medical Research Council
    Inventors: Paul H. Dear, Madan Thangavelu, Alan Bankier
  • Publication number: 20040224324
    Abstract: The invention provides a method of mapping a nucleic acid, comprising the steps of: a) preparing a HAPPY mapping panel comprising a plurality of nucleic acid samples derived from a nucleic acid to be mapped; b) labelling the nucleic acids in the mapping panel; c) preparing a plurality of probes which are complementary to marker sequences present in the nucleic acid to be mapped and immobilising the probes on a solid phase; d) bringing one or more members of the mapping panel into contact with each probe, such that the probe hybridises to sequences in the mapping panel which are complementary thereto; and e) removing non-hybridised nucleic acids and detecting hybridisation of mapping panel nucleic acids to the probe.
    Type: Application
    Filed: December 18, 2003
    Publication date: November 11, 2004
    Applicant: Medical Research Council
    Inventor: Paul H. Dear