Abstract: Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof.

Abstract: Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.

Abstract: Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective co-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.

Abstract: Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.

Abstract: Composition comprising a polymeric micelle and an associated polynucleotide.

Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.

Abstract: Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.

Abstract: Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer.

Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

Abstract: A double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5?-methyl-pyrimidine and/or at least one 2?-O-methyl ribonucleotide, and a method of improving ribonuclease stability, reducing off-target effects of a double stranded siRNA molecule, or of reducing interferon responsiveness of a double stranded siRNA molecule using such dsRNA.

Abstract: A system for reconfigurably adapting a dental chair for use, including, e.g., use from the right side or left side, use by right-handed or left-handed practitioners and use in various dentistry practice styles, may include a link arm, a primary arm and a secondary arm. The link arm is pivotably connectible to a rear side of the dental chair. The primary arm is pivotably connectible to the link arm to swing in a generally horizontal plane about a generally vertical axis. The secondary arm is coupleable to the link arm, preferably along substantially the same axis. The secondary arm has multiple pivotably connected segments allowing its distal end to be positioned as desired.

Abstract: A cleaning apparatus having a housing, a motor, a battery, and a removable cleaning attachment. The housing comprising a rigid subassembly shell and a resilient cover. The cover is injection molded onto the shell to waterproof a majority of the shell. The shell has raised portions on its exterior that are used to position the shell in the injection mold. After molding is completed, the cover surrounds the raised portions, but does not cover them.

Abstract: Microminiature valve includes a valve seat substrate having opposed upper and lower major surfaces, a flow channel extending from said lower major surface to a port on an exterior surface of the microminiature valve, an integral valve seat structure extending from the upper major surface, the valve seat structure surrounding the flow channel and including a valve seat, and a recess located in a surround in the upper major surface, wherein the recess surrounds the valve seat structure. A diaphragm preferably formed of silicon is positionable by deflection against the valve seat substrate and includes an lower surface functional as a valve face and positionable in a closed position with respect to the valve seat to obstruct fluid flow through said flow channel, and in an open position with respect to the valve seat to permit fluid flow through said flow channel.

Abstract: A cleaning apparatus having a housing, a motor, a battery, and a removable cleaning attachment. The housing comprising a rigid subassembly shell and a resilient cover. The cover is injection molded onto the shell to waterproof a majority of the shell. The shell has raised portions on its exterior that are used to position the shell in the injection mold. After molding is completed, the cover surrounds the raised portions, but does not cover them.

Abstract: A cleaning apparatus having a housing, a motor, a transmission, an attachment stud, and a cleaning attachment removably connected to the stud. The stud has a leading section with a general triangular block shape and three generally triangular shaped cantilevered tips. The stud is received through a generally triangular shaped aperture in the cleaning attachment. The apparatus can reverse the normal rotation direction of the stud to allow the cleaning attachment to quickly disconnect from the stud without a user having to hold the cleaning attachment.

Abstract: A fixed-volume injector assembly having backflush capability is useful for injecting a sample into a gas chromatograph. The injector assembly has a sampling mode of operation, an injection mode of operation and a backflush mode of operation. In the sampling mode, sample is drawn into sampling chamber (11). In the injection mode, sample is injected into an injection channel which conducts the sample to a destination stream. In the backflush mode, carrier fluid flows through the injector assembly in the opposite direction. The injector assembly is designed to connect to precolumn (28) and analytical column (20) so that, in the backflush mode, precolumn (28) is backflushed. Advantages of the injector assembly include the ability to pressurize the sample before injection and to use a single carrier fluid source. In addition, the flow channels of the injector assembly are readily miniaturized.

Abstract: A miniature gas chromatograph with thermostatically-controlled heating of its component parts which contact and conduct the sample to the analytical column. The microvalve assembly of the gas chromatograph is heated by passing a thermostatically-controlled electrical current through a metallic conductor formed on a surface of the microvalve assembly. The tubing which conducts sample from the gas chromatograph sample inlet to the microvalve assembly is heated by passing a thermostatically-controlled electrical current directly through the tubing or through a metal layer formed around the tubing. The sample inlet fitting is heated by a wire heater element wrapped around it. Each heater has an associated temperature sensor for controlling the amount of heating to maintain a predetermined temperature.

Abstract: An automated micro-valve assembly injects a fixed fluid volume fluid into a destination stream. The fluid to be injected (inject fluid) is conducted into a chamber. Flow of inject fluid out of the chamber is prevented by sealing the ends of the chamber using valves or by application of pressure. A fixed volume of inject fluid is injected into the destination stream by pressurizing the inject fluid in the chamber and opening an inject valve which connects the chamber to the destination stream. The pressurization of the inject fluid in the chamber above the destination stream pressure is effected by a T-valve which controls the flow of a purge fluid into the chamber. The purge fluid emitted by the T-valve flows toward the inject valve, forming a fluid-lock which establishes the fixed-volume to be injected. During the injection, the inject fluid is driven by the purge fluid pressure to flow through the inject valve into a destination passage which communicates with the destination stream.

Abstract: A vacuum cleaner with a housing, a source of vacuum, and an air chamber located in the housing and connected to the source of vacuum. The housing includes a bottom member, a top member and a handle contacting and extending from a top surface of the top member. The handle is separately connected to the bottom member such that the handle is supported by both the top and bottom members. The air chamber is located in the housing between the top and bottom members with an inlet aperture and an exhaust aperture located at the exterior of the housing. The air chamber is comprised of two half sections that combine to form an inlet conduit, an outlet conduit, and an impeller chamber. An impeller of the source of vacuum is located in the impeller chamber. The source of vacuum has a motor with a first end connected to the impeller and a second end forming a drive shaft to drive a belt connected to a rotatable brush assembly.