Patents by Inventor Paul J. Reider

Paul J. Reider has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymic process for preparing leukotriene antagonists
    Patent number: 5070022
    Abstract: Disclosed is a process for preparing the R and S enantiomers of a compound of the formula; ##STR1## which comprises; (1) reacting an enzyme with a prochiral diester of the formula ##STR2## where M.sup.1 and M.sup.2 are the same, to produce a chiral monoester of the compound of formula II;(2) treating the chiral monoester product of step (1) with an amine and a trialkyl aluminum compound to produce the R enantiomer of the compound of formula I; or reacting the chiral monoester product of step (1) with an acid activating agent, an amine, and a base to produce the S enantiomer of the compound of formula I.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: December 3, 1991
    Assignee: Merck & Co., Inc.
    Inventors: David L. Hughes, Paul J. Reider, Joseph S. Amato, James J. Bergan, Edward J. J. Grabowski
  • Process for unsymmetrical dithioacetals and dithioketals
    Patent number: 4883878
    Abstract: This invention relates to a novel process for preparing unsymmetrical dithioacetals and dithioketals from aryl aldehydes and ketones.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: November 28, 1989
    Assignee: Merck & Co. Inc.
    Inventors: Joseph S. Amato, James M. McNamara, Johnnie L. Leazer, Jr., Paul J. Reider, Robert A. Reamer
  • Process for resolution and racemization of amines with acidic .alpha.-hydrogens
    Patent number: 4859771
    Abstract: An economical, one-pot process for resolution-racemization of primary amines with .alpha.-hydrogens via selective crystallization of diastereomeric chiral sulfonic acid salts and the subsequent in situ racemization of the other enantiomer by the catalytic addition of aromatic aldehydes, and a key process intermediate thereof.
    Type: Grant
    Filed: January 19, 1989
    Date of Patent: August 22, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Paul J. Reider, Edward J. J. Grabowski
  • Preparation of 2-Deutero-D-serine
    Patent number: 4582931
    Abstract: A process for the preparation of 2-Deutero-D-serine and its fluorination is disclosed.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: April 15, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. J. Grabowski, Paul J. Reider