Patents by Inventor Paul Krimpenfort

Paul Krimpenfort has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of recombinant polypeptides by bovine species and transgenic methods
    Publication number: 20050198698
    Abstract: Transgenes for producing recombinant polypeptides transgenic bovine species. A transgene for producing recombinant polypeptides in the milk of transgenic bovine species comprises at least one expression regulation sequence, a secretory DNA sequence encoding a secretory signal sequence which is functional in mammary secretory cells of the bovine species and a recombinant DNA sequence encoding the recombinant polypeptide. Also included are methods for producing transgenic bovine species. The method includes introducing the above transgene into an embryonal target cell of a bovine species, transplanting the transgenic embryonic target cell formed thereby into a recipient bovine parent and identifying at least one female offspring which is capable of producing the recombinant polypeptide in its milk.
    Type: Application
    Filed: November 12, 2004
    Publication date: September 8, 2005
    Applicant: Pharming B.V., a Netherlands corporation
    Inventors: Herman DeBoer, Rein Strijker, Herbert Heyneker, Gerard Plantenburg, Sang Lee, Frank Pieper, Paul Krimpenfort
  • Homologous recombination in mammalian cells
    Patent number: 5721367
    Abstract: The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 24, 1998
    Assignee: Pharming B.V.
    Inventors: Robert M. Kay, Anton Berns, Paul Krimpenfort, Frank Pieper, Rein Strijker
  • Homologous recombination in mammalian cells
    Patent number: 5612205
    Abstract: The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: March 18, 1997
    Assignee: GenPharm International, Incorporated
    Inventors: Robert M. Kay, Anton Berns, Paul Krimpenfort, Frank Pieper, Rein Strijker