Patents by Inventor Paul Kurtulik

Paul Kurtulik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulations of cyclopropanecarboxylic acid {2-[(1S)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide
    Patent number: 9884042
    Abstract: Pharmaceutical compositions and single unit dosage forms of {2-[(IS)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate thereof, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as cancer or an inflammatory disease.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: February 6, 2018
    Assignee: Celgene Corporation
    Inventors: Nathan Boersen, Wai Yip Lee, Ho-Wah Hui, Paul Kurtulik
  • Oral dosage forms of cyclopropanecarboxylic acid {2-[(1S)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide
    Patent number: 9757355
    Abstract: Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: September 12, 2017
    Assignee: Celgene Corporation
    Inventors: Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
  • Nanosuspension of a poorly soluble drug via microfluidization process
    Patent number: 9616019
    Abstract: Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: April 11, 2017
    Assignee: Celgene Corporation
    Inventors: Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
  • NANOSUSPENSION OF A POORLY SOLUBLE DRUG VIA MICROFLUIDIZATION PROCESS
    Publication number: 20150265534
    Abstract: Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.
    Type: Application
    Filed: April 1, 2015
    Publication date: September 24, 2015
    Inventors: Ming J. CHEN, Ho-Wah HUI, Thomas LEE, Paul KURTULIK, Sekhar SURAPANENI
  • FORMULATIONS OF CYCLOPROPANECARBOXYLIC ACID -AMIDE
    Publication number: 20150190374
    Abstract: Pharmaceutical compositions and single unit dosage forms of {2-[(IS)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindo1-4-yl}-amide, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate thereof, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as cancer or an inflammatory disease.
    Type: Application
    Filed: September 13, 2012
    Publication date: July 9, 2015
    Inventors: Nathan Boersen, Wai Yip Lee, Ho-Wah Hui, Paul Kurtulik
  • Nanosuspension of a poorly soluble drug via microfluidization process
    Patent number: 9023886
    Abstract: Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: May 5, 2015
    Assignee: Celgene Corporation
    Inventors: Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
  • ORAL DOSAGE FORMS OF CYCLOPROPANECARBOXYLIC ACID -AMIDE
    Publication number: 20140093561
    Abstract: Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders.
    Type: Application
    Filed: January 9, 2012
    Publication date: April 3, 2014
    Applicant: CELGENE CORPORATION
    Inventors: Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
  • Nanosuspension of a Poorly Soluble Drug via Microfluidization Process
    Publication number: 20110124702
    Abstract: Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.
    Type: Application
    Filed: November 9, 2010
    Publication date: May 26, 2011
    Inventors: Ming J. CHEN, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni