Patents by Inventor Paul Laeseke
Paul Laeseke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11883224Abstract: A system and method are provided for creating an image including quantified flow within vessels of a subject. The method includes providing a single-sweep, three-dimensional (3D) image volume acquired from a subject during a single pass of a computed tomography (CT) imaging system as the subject receives a dose of a contrast agent and determining a phase shift corresponding to pulsatile contrast in vessels within the single-sweep, 3D image volume. The method further includes quantifying a flow through the vessels within the single-sweep, 3D image volume using the phase shift and generating a report including indicating flow through the vessels within the 3D image volume.Type: GrantFiled: August 6, 2021Date of Patent: January 30, 2024Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Martin Wagner, Paul Laeseke, Michael Speidel
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Patent number: 11839761Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.Type: GrantFiled: January 28, 2021Date of Patent: December 12, 2023Assignee: Wisconsin Alumni Research FoundationInventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
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Publication number: 20230329658Abstract: A system and method are provided for creating both angiographic images of a subject and dynamic images of the subject from imaging data acquired during an imaging acquisition. The method includes operating an imaging system to perform an imaging acquisition by delivering interspersed doses of high doses of the ionizing radiation and low doses of the ionizing radiation, wherein more low doses of the ionizing radiation are delivered than high doses of ionizing radiation during the imaging acquisition to thereby acquire the imaging data with a high frame rate of low dose data and a low frame rate of high dose data. The method also includes generating at least volumetric angiographic images of the subject and dynamic images of the subject from the imaging data.Type: ApplicationFiled: April 15, 2022Publication date: October 19, 2023Inventors: Michael Speidel, Paul Laeseke, Carson Hoffman, Joseph Whitehead
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Publication number: 20230074581Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.Type: ApplicationFiled: November 15, 2022Publication date: March 9, 2023Inventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
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Publication number: 20230042953Abstract: A system and method are provided for creating an image including quantified flow within vessels of a subject. The method includes providing a single-sweep, three-dimensional (3D) image volume acquired from a subject during a single pass of a computed tomography (CT) imaging system as the subject receives a dose of a contrast agent and determining a phase shift corresponding to pulsatile contrast in vessels within the single-sweep, 3D image volume. The method further includes quantifying a flow through the vessels within the single-sweep, 3D image volume using the phase shift and generating a report including indicating flow through the vessels within the 3D image volume.Type: ApplicationFiled: August 6, 2021Publication date: February 9, 2023Inventors: Martin Wagner, Paul Laeseke, Michael Speidel
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Patent number: 11380006Abstract: A radiography machine provides information about the absolute dimension of imaged objects with as few as two images taken along a common axis at different separations. The information gathered in this way may also be used to deduce absolute or relative separation of the objects along the common axis.Type: GrantFiled: January 22, 2020Date of Patent: July 5, 2022Assignee: Wisconsin Alumni Research FoundationInventors: Paul Laeseke, Carson Hoffman
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Patent number: 11207171Abstract: Aspects of the disclosure are directed to methods and/or apparatuses involving the deployment and coupling of catheters. As may be implemented in accordance with one or more embodiments, each of first and second catheters extend from a proximal end to a distal end and has a magnet. The catheters may be deployed, and the distal ends of the respective catheters can be aligned and connected via magnetic coupling of the magnets to one another. A shaft structure is configured and arranged to extend within the first catheter and into the second catheter, through the connected distal ends of the respective catheters.Type: GrantFiled: April 29, 2019Date of Patent: December 28, 2021Assignee: Wisconsin Alumni Research FoundationInventors: Paul Laeseke, Michael Woods, Emily Rae Foran, Will Robert Flanigan, Alexandra Nicol Doersch, Brett Conor Struthers, Joseph Alexander Ashley
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Publication number: 20210225022Abstract: A radiography machine provides information about the absolute dimension of imaged objects with as few as two images taken along a common axis at different separations. The information gathered in this way may also be used to deduce absolute or relative separation of the objects along the common axis.Type: ApplicationFiled: January 22, 2020Publication date: July 22, 2021Inventors: Paul Laeseke, Carson Hoffman
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Publication number: 20210146127Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.Type: ApplicationFiled: January 28, 2021Publication date: May 20, 2021Inventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
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Patent number: 10918861Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.Type: GrantFiled: July 24, 2018Date of Patent: February 16, 2021Assignee: Wisconsin Alumni Research FoundationInventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
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Publication number: 20200222168Abstract: Aspects of the disclosure are directed to methods and/or apparatuses involving the deployment and coupling of catheters. As may be implemented in accordance with one or more embodiments, each of first and second catheters extend from a proximal end to a distal end and has a magnet. The catheters may be deployed, and the distal ends of the respective catheters can be aligned and connected via magnetic coupling of the magnets to one another. A shaft structure is configured and arranged to extend within the first catheter and into the second catheter, through the connected distal ends of the respective catheters.Type: ApplicationFiled: April 29, 2019Publication date: July 16, 2020Inventors: Paul Laeseke, Michael Woods, Emily Rae Foran, Will Robert Flanigan, Alexandra Nicol Doersch, Brett Conor Struthers, Joseph Alexander Ashley
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Publication number: 20200030602Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.Type: ApplicationFiled: July 24, 2018Publication date: January 30, 2020Inventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
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Publication number: 20080045938Abstract: The present invention relates to systems and devices for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In particular, the present invention relates to systems and devices for the delivery of energy with a linear array of antenna components having optimized energy delivery characteristics. In certain embodiments, methods are provided for treating a tissue region (e.g., a tumor) through application of energy with the systems and devices of the present invention.Type: ApplicationFiled: July 16, 2007Publication date: February 21, 2008Applicant: MicrablateInventors: Daniel van der Weide, Fred Lee, Paul Laeseke, Christopher Brace
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Publication number: 20080033424Abstract: The present invention relates to systems and devices for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In particular, the present invention relates to systems and devices for the delivery of energy with heat transfer ability. In some embodiments, the systems and devices also have variable characteristic impedance as a result of the use of heat transfer materials. In certain embodiments, methods are provided for treating a tissue region (e.g., a tumor) through application of energy with the systems and devices of the present invention.Type: ApplicationFiled: March 26, 2007Publication date: February 7, 2008Applicant: MicrablateInventors: Daniel van der Weide, Fred Lee, Paul Laeseke, Christopher Brace
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Publication number: 20070288079Abstract: The present invention relates to systems and devices for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In particular, the present invention relates to systems and devices for the delivery of energy with optimized characteristic impedance. In certain embodiments, methods are provided for treating a tissue region (e.g., a tumor) through application of energy with the systems and devices of the present invention.Type: ApplicationFiled: March 26, 2007Publication date: December 13, 2007Applicant: MicrablateInventors: Daniel van der Weide, Fred Lee, Paul Laeseke, Christopher Brace
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Publication number: 20070282319Abstract: The present invention relates to systems and devices for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In particular, the present invention relates to systems and devices for the delivery of energy employing a center fed dipole component. In certain embodiments, methods are provided for treating a tissue region (e.g., a tumor) through application of energy with the systems and devices of the present invention.Type: ApplicationFiled: March 26, 2007Publication date: December 6, 2007Applicant: Micrablate, Inc.Inventors: Daniel van der Weide, Fred Lee, Paul Laeseke, Christopher Brace
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Publication number: 20070055224Abstract: A microwave device that can be used to effectively treat esophageal pathologies comprises a coaxial, triaxial or quadraxial microwave antenna housed in an esophageal dilator or balloon. The device can be introduced into the esophagus alongside or through an endoscope, and will deliver microwave energy to tissue. This energy heats the affected tissue, which subsequently undergoes necrosis thereby eliminating the potential of the tissue to undergo malignant transformation. The dilator or balloon is used to keep the antenna in the center of the lumen allowing for symmetrical heating of the esophagus. The depth of penetration of the coagulation effect can be varied depending on the amount of power that is applied, the location of the antenna relative to the tissue, and the duration of the power application.Type: ApplicationFiled: August 11, 2006Publication date: March 8, 2007Inventors: Fred Lee, Christopher Brace, Paul Laeseke, Daniel Weide, Deepak Gopal, Patrick Pfau, Lisa Sampson
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Publication number: 20070049918Abstract: A method and system delivers microwave energy to a vessel, such as a vein for the treatment of varicose veins, in a controllable heating pattern and to provide relatively fast heating and ablation of the vessel. The method and system comprises a microwave delivery device for heating the vessel, and a microwave power source for supplying microwave power to the delivery device. The method and system may also include a cooling system, a temperature monitoring, feedback and control system, an ultrasound or other imaging device, and/or a device for assuring generally uniform energy delivery in the vessel.Type: ApplicationFiled: August 24, 2006Publication date: March 1, 2007Inventors: Daniel van der Weide, Fred Lee, Christopher Brace, Paul Laeseke
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Publication number: 20070016180Abstract: A medical instrument or device used to decrease blood loss during surgery and/or other medical procedures. The device includes a microwave antenna housed in a handset (or laparoscopic probe) that is placed in close proximity to the tissue of interest. The device runs in the microwave spectrum and receives power from a from a microwave generator. When turned on (triggered), the device delivers microwave energy to tissue, providing a cutting or cautery effect.Type: ApplicationFiled: May 24, 2006Publication date: January 18, 2007Inventors: Fred Lee, Christopher Brace, Paul Laeseke, Daniel van der Weide
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Publication number: 20060276780Abstract: A method and device delivers microwave power to an antenna through a coaxial cable utilizing air or other gases as its dielectric core. The cable includes supports made of low-loss materials to keep the inner conductor centered in the cable, and defining spaces therebetween for the air or gas. Channels in the supports allow the air or gas to circulate in the cable. The gas may be chilled or cooled to provide an addition level of heat dissipation. The device enables delivery of large amounts of power to tissue without undue heating of the feed cable or peripheral tissues, and without increasing the diameter of the feeding cable or antenna, keeping the antenna safe for percutaneous use.Type: ApplicationFiled: September 28, 2005Publication date: December 7, 2006Inventors: Christopher Brace, Daniel van der Weide, Paul Laeseke, Fred Lee