Patents by Inventor Paul Polakis

Paul Polakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9556267
    Abstract: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: January 31, 2017
    Assignee: Genentech, Inc.
    Inventors: Eric Bourhis, Rick Carano, Andrea Cochran, Mike Costa, Venita DeAlmeida, James Ernst, Yan Gong, Rami Hannoush, Paul Polakis, Bonnee Rubinfeld, Mark Solloway, Yan Wu
  • Publication number: 20170002086
    Abstract: The invention provides immunoconjugates and methods of using the same.
    Type: Application
    Filed: June 14, 2016
    Publication date: January 5, 2017
    Applicant: Genentech, Inc.
    Inventors: Paul Polakis, Peter Dragovich, Thomas Harden Pillow, Shang-Fan Yu
  • Publication number: 20160296634
    Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: November 19, 2015
    Publication date: October 13, 2016
    Applicant: GENENTECH, INC.
    Inventors: Mark DENNIS, William MALLET, Paul POLAKIS
  • Patent number: 9464141
    Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: October 11, 2016
    Assignee: Genentech, Inc.
    Inventors: Jyoti Asundi, Suzanna Clark, Paul Polakis
  • Patent number: 9463251
    Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a nemorubicin derivative.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: October 11, 2016
    Assignee: Genentech, Inc.
    Inventors: Jyoti Asundi, Suzanna Clark, Paul Polakis
  • Publication number: 20160168261
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
    Type: Application
    Filed: November 30, 2015
    Publication date: June 16, 2016
    Applicant: Genentech, Inc.
    Inventors: Mark DENNIS, Jan MARIK, Paul POLAKIS, Bonnee RUBINFELD, Simon WILLIAMS
  • Publication number: 20160159910
    Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: September 11, 2015
    Publication date: June 9, 2016
    Applicant: GENENTECH, INC.
    Inventors: Steven R. Leong, Andrew Polson, Paul Polakis, Yan Wu, Wei-Ching Liang, Ron Firestein
  • Publication number: 20160102146
    Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: September 17, 2015
    Publication date: April 14, 2016
    Applicant: GENENTECH, INC.
    Inventors: Jo-Anne Hongo, Weiguang Mao, Paul Polakis, Andrew Polson, Rajesh Vij, Yan Wu, Wei-Ching Liang
  • Patent number: 9290578
    Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: March 22, 2016
    Assignee: Genentech, Inc.
    Inventors: Jyoti Asundi, Ron Firestein, Paul Polakis, Chie Sakanaka, Peter Chang, Rayna Takaki Venook
  • Publication number: 20160017040
    Abstract: The disclosure provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 21, 2016
    Inventors: Steven R. Leong, Andrew Polson, Paul Polakis, Yan Wu, Wei-Ching Liang, Ron Firestein
  • Publication number: 20160017049
    Abstract: The invention provides anti-GPC3 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: May 21, 2015
    Publication date: January 21, 2016
    Inventors: Paul Polakis, Youjun Chen
  • Publication number: 20150374847
    Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: May 6, 2015
    Publication date: December 31, 2015
    Inventors: Youjun Chen, William Mallet, Paul Polakis, Christine Tan, Jyoti Asundi, Suzanna Clark
  • Patent number: 9175089
    Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: November 3, 2015
    Assignee: Genentech, Inc.
    Inventors: Jo-Anne Hongo, Weiguang Mao, Paul Polakis, Andrew Polson, Rajesh Vij, Yan Wu, Wei-Ching Liang
  • Publication number: 20150196660
    Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a nemorubicin derivative.
    Type: Application
    Filed: August 1, 2013
    Publication date: July 16, 2015
    Inventors: Jyoti Asundi, Suzanna Clark, Paul Polakis
  • Publication number: 20150183883
    Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.
    Type: Application
    Filed: August 1, 2013
    Publication date: July 2, 2015
    Inventors: Jyoti Asundi, Suzanna Clark, Paul Polakis
  • Publication number: 20150166674
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
    Type: Application
    Filed: October 17, 2014
    Publication date: June 18, 2015
    Inventors: Mark S. DENNIS, Bonnee RUBINFELD, Paul POLAKIS, Aya JAKOBOVITS
  • Patent number: 9056910
    Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: June 16, 2015
    Assignee: Genentech, Inc.
    Inventors: Youjun Chen, William Mallet, Paul Polakis, Christine Tan, Jyoti Asundi, Suzanna Clark
  • Publication number: 20150158952
    Abstract: Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p??I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
    Type: Application
    Filed: November 24, 2014
    Publication date: June 11, 2015
    Applicant: GENENTECH, INC.
    Inventors: Weiguang MAO, Jagath Reddy JUNUTULA, Paul POLAKIS
  • Publication number: 20150132218
    Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.
    Type: Application
    Filed: October 20, 2014
    Publication date: May 14, 2015
    Inventors: Jyoti Asundi, Ron Firestein, Paul Polakis, Chie Sakanaka, Peter Chang, Rayna Takaki Venook
  • Patent number: 9029511
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: May 12, 2015
    Assignee: Genentech, Inc.
    Inventors: Mark Dennis, Bonnee Rubinfeld, Paul Polakis