Patents by Inventor Paul R. Brodfuehrer

Paul R. Brodfuehrer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors
    Patent number: 6875867
    Abstract: A process is provided for preparing chiral diol sulfones of the structure where R3 is preferably where R4a is preferably aryl such as phenyl, and R1a is preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: April 5, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Paul R. Brodfuehrer, Thomas R. Sattelberg, Joydeep Kant, Xinhua Qian
  • Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors
    Publication number: 20030018199
    Abstract: A process is provided for preparing chiral diol sulfones of the structure 1
    Type: Application
    Filed: May 30, 2002
    Publication date: January 23, 2003
    Inventors: Paul R. Brodfuehrer, Thomas R. Sattelberg, Joydeep Kant, Xinhua Qian
  • Method for epoxidation of 3-methylenecyclopropanes
    Patent number: 6353122
    Abstract: The present invention provides a process for the expoxidation of a protected 3-methylene-(trans)-1,2,-hydroxymethylcyclopropane with cyclohexanone and potassium peroxymonosulfate and subsequent rearrangement to provide the corresponding cyclobutanone.
    Type: Grant
    Filed: February 4, 1998
    Date of Patent: March 5, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Paul R. Brodfuehrer, Thomas R. Sattleberg, Sr.
  • Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carb oxylic acids
    Patent number: 5637694
    Abstract: This invention relates to a method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids from 3-hydroxymethyl-3-cephem-4-carboxylic acids in an aqueous medium for a practical, large-scale production. Moreover, the invention provides an ideal intermediate for the process.
    Type: Grant
    Filed: April 5, 1996
    Date of Patent: June 10, 1997
    Assignee: Briston-Myers Squibb Company
    Inventors: J. Gregory Reid, Paul R. Brodfuehrer, Patrick R. Smith
  • Process for the preparation of nucleotides
    Patent number: 5591852
    Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 7, 1997
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Purushotham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
  • Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carb oxylic acids
    Patent number: 5552542
    Abstract: This invention relates to a method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids from 3-hydroxymethyl-3-cephem-4-carboxylic acids in an aqueous medium for a practical, large-scale production. Moreover, the invention provides an ideal intermediate for the process.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: September 3, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: J. Gregory Reid, Paul R. Brodfuehrer, Patrick R. Smith
  • Process for the preparation of nucleotides
    Patent number: 5476938
    Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: December 19, 1995
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Purushortham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
  • Dideoxyinosine by enzymatic deamination of dideoxyadenosine
    Patent number: 5011774
    Abstract: A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: April 30, 1991
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Vittorio Farina, Daniel A. Benigni, Paul R. Brodfuehrer
  • Process for preparing cephalosporin intermediates
    Patent number: 4868294
    Abstract: Processes for the preparation of stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl, and Nu and Nu.sup..sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the .DELTA..sup.2 isomer; processes for intermediates in the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.
    Type: Grant
    Filed: March 23, 1987
    Date of Patent: September 19, 1989
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Paul R. Brodfuehrer, Chet Sapino, Jr., Kun M. Shih, Donald G. Walker
  • Cephalosporin intermediates
    Patent number: 4714760
    Abstract: Stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl and Nu and Nu.sup..sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the .DELTA..sup.2 isomer; processes for, and intermediates in, the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: December 22, 1987
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Paul R. Brodfuehrer, Chet Sapino, Jr., Kun M. Shih, Donald G. Walker