Patents by Inventor Paul Santerre

Paul Santerre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240294697
    Abstract: Amphiphilic oligomers are provided that yield phase-separated gels suitable for sustained release drug delivery. The amphiphilic backbone includes a hydrophilic domain and a degradable hydrophobic domain, which are linked with an isocyanate group, while the terminal domains on the oligomer are functionalized with catechol adhesive groups capable of cross-linking.
    Type: Application
    Filed: June 20, 2022
    Publication date: September 5, 2024
    Inventors: Paul SANTERRE, Eli SONE, Angus Wen-Tsung LAM
  • Patent number: 11976163
    Abstract: The invention relates to carbonate-linked surface modifying macromolecules and admixtures thereof. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules).
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: May 7, 2024
    Assignee: Evonik Canada Inc.
    Inventors: J. Paul Santerre, Sanjoy Mullick
  • Publication number: 20230225975
    Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.
    Type: Application
    Filed: February 16, 2023
    Publication date: July 20, 2023
    Inventors: Ian Charles PARRAG, Matthew Alexander John STATHAM, Kyle BATTISTON, Dimitra LOUKA, Hans Christian FISCHER, J. Paul SANTERRE, Wendy Alison NAIMARK
  • Publication number: 20230012485
    Abstract: An adhesive device for biomedical applications is provided comprising a support and one or more water insoluble compounds of structure 1 wherein B is an oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW<10,000 g/mol, Linker L is a urethane, urea bond, or amide bond; Linker L? is a urethane or urea bond, A is a chain extender of Mw?3000 g/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups, W is a terminal adhesive benzene-1,2-diol derivative or a terminal adhesive benzene-1,2,3-triol derivative, m is 0 or 1; and n is 0, 1, 2, 3 or 4 or a cross-linked polymer formed from said compounds. The compound(s) have a Tg lower than 25° C.
    Type: Application
    Filed: December 21, 2020
    Publication date: January 19, 2023
    Inventors: Paul SANTERRE, Eli SONE, Michael FLOROS, Jeffrey FLALKOV, Cari WHYNE
  • Publication number: 20230001046
    Abstract: A biocompatible adhesive is provided comprising one or more water insoluble compounds of structure (1) wherein B is an oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW<10,000 g/mol, Linker L is a urethane, urea bond, or amide bond; Linker L? is a urethane or urea bond, A is a chain extender of Mw?3000 g/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups, W is a terminal adhesive benzene-1,2-diol derivative or a terminal adhesive benzene-1,2,3-diol derivative, m is 0 or 1; and n is 0, 1, 2, 3 or 4; or a cross-linked polymer formed from said compounds. The compound(s) have a Tg lower than 25° C. The biocompatible adhesive is suitable for use without solvent.
    Type: Application
    Filed: December 21, 2020
    Publication date: January 5, 2023
    Inventors: Paul SANTERRE, Eli SONE, Michael FLOROS
  • Publication number: 20220395608
    Abstract: A water soluble biocompatible adhesive is provided comprising one or more compounds of structure 1 wherein B is an oligomer derived from a polyether or polyalkylene glycol, with a MW<5,000 g/mol, Linker L is a urethane, urea bond, or amide bond; Linker L? is a urethane or urea bond, A is a chain extender of Mw?3000 g/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups, W is a terminal adhesive benzene-1,2-diol derivative or a terminal adhesive benzene-1,2,3-diol derivative, m is 0 or 1; and n is 0, 1, 2, 3 or 4. The compound(s) have a Tg lower than 25° C. The biocompatible adhesive is suitable for use without solvent.
    Type: Application
    Filed: December 21, 2020
    Publication date: December 15, 2022
    Inventors: Paul SANTERRE, Eli SONE, Michael FLOROS
  • Publication number: 20220289787
    Abstract: The present invention is directed towards articles comprising a steroid material comprising a steroid dimer and at least one therapeutic agent distributed throughout the steroid material and the use of such articles in sustained release delivery systems. Said article may be fibers, fiber meshes, woven fabrics, non-woven fabrics, films, pellets, cylinders, microparticles, nanoparticles, shaped articles or coatings on a substrate (such as an implant). Control of the release profile of the at least one therapeutic agent can be achieved via selection of the steroids within the steroid dimer, the linker conjugating the steroids within the dimer, the linkage groups between the steroids and the linker, the surface area of the article, the location of the at least one therapeutic agent within the article and the amount of the at least one therapeutic agent within the article.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 15, 2022
    Inventors: Ian Charles PARRAG, Matthew Alexander John STATHAM, J. Paul SANTERRE, Wendy Alison NAIMARK, Adam Bruce DALEY
  • Publication number: 20220288277
    Abstract: The disclosure features surface coatings formed from dimeric steroid prodrugs for the extended delivery of a drug from a surface, and for the treatment of a disease or condition. Also provided herein are drug depots formed from dimeric steroid prodrugs for the extended delivery of a drug for use in combination with implantable medical devices. Said dimeric steroid prodrugs are represented by the formula D1-L-D2, wherein D1 and D2 are independently a steroid radical and L is a linker covalently linking D1 to D2.
    Type: Application
    Filed: July 9, 2020
    Publication date: September 15, 2022
    Inventors: Ian Charles PARRAG, Matthew Alexander John STATHAM, Dimitra LOUKA, Kyle Giovanni BATTISTON, J. Paul SANTERRE, Wendy Alison NAIMARK, Bernadette ILAGAN, Gillian Claire MACKEY, Hans Christian FISCHER, Jamie Robert SWENOR, Kelli-Anne Nicole WOOTTON
  • Publication number: 20220047773
    Abstract: The invention features the use of a matrix consisting of low molecular weight components for use as a self-eliminating coating for implantable medical devices. The matrix coatings can be used to enhance biocompatibility and to control the local delivery of biologically active agents.
    Type: Application
    Filed: March 23, 2021
    Publication date: February 17, 2022
    Inventors: Roseita ESFAND, J. Paul SANTERRE, Mark J. ERNSTING, Vivian Z. WANG, Sylvia TJAHYADI
  • Publication number: 20220040385
    Abstract: The invention relates to oligofluorinated coatings and their use in drag delivery. The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue. This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.
    Type: Application
    Filed: April 16, 2021
    Publication date: February 10, 2022
    Inventors: Roseita ESFAND, J. Paul SANTERRE, Sylvia TJAHYADI, Bernadette ILAGAN
  • Publication number: 20210268543
    Abstract: The invention features surfaces formed from a base polymer admixed with an additive of the invention. The surfaces can be resistant to bacterial adhesion. The surfaces of the invention can be applied to: (a) any medical device or material that is implanted in or juxtaposed to a human or animal tissue or body fluid, in vivo or ex vivo, permanently or for a short period, and (b) any useful article, material or device, medical or not, which is to maintain a human or animal health-safe unfouled state of cleanliness over a period of time. In these medical and non-medical applications it is known that undesirable fouling phenomenon can take place which might harm a patient, user or consumer of the compromised device, equipment or material processed by, transported or stored in contamination prone articles, equipment or environments. Such fouling phenomena include biofilm development and bacterial colony development.
    Type: Application
    Filed: May 17, 2019
    Publication date: September 2, 2021
    Inventors: Alexandra Piotrowicz, Kyle William Macdonald, Antonio Cillero Rodrigo, Sanjoy Mullick, Jamie Robert Swenor, J. Paul Santerre, Jeannette Ho
  • Publication number: 20210205222
    Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
    Type: Application
    Filed: January 8, 2021
    Publication date: July 8, 2021
    Inventors: Ian Charles PARRAG, Matthew Alexander John STATHAM, Kyle BATTISTON, Dimitra LOUKA, Hans Christian FISCHER, J. Paul SANTERRE, Wendy Alison NAIMARK, Roseita Esfand
  • Publication number: 20210113457
    Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.
    Type: Application
    Filed: February 1, 2019
    Publication date: April 22, 2021
    Inventors: Ian Charles PARRAG, Matthew Alexander John STATHAM, Kyle BATTISTON, Dimitra LOUKA, Hans Christian FISCHER, J. Paul SANTERRE, Wendy Alison NAIMARK
  • Patent number: 10975197
    Abstract: The invention relates to ester-linked surface-modifying macromolecules and admixtures thereof as shown below by the representative compounds. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules).
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 13, 2021
    Assignee: Evonik Canada Inc.
    Inventors: Sanjoy Mullick, J. Paul Santerre, Jeannette Ho
  • Patent number: 10973950
    Abstract: Polar hydrophobic ionic materials and, in particular, polar hydrophobic ionic polyurethanes having a minimum ratio of hydrophobic and anionic components to the remainder of the polymer components are provided that exhibit reduced IgG Fab exposure.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: April 13, 2021
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Paul Santerre, Kyle Battiston
  • Patent number: 10959954
    Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: March 30, 2021
    Assignee: RIPPLE THERAPEUTICS CORPORATION
    Inventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark, Roseita Esfand
  • Patent number: 10945958
    Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: March 16, 2021
    Assignee: RIPPLE THERAPEUTICS CORPORATION
    Inventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark
  • Publication number: 20210009502
    Abstract: The invention relates to carbonate-linked surface modifying macromolecules and admixtures thereof. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules).
    Type: Application
    Filed: March 7, 2019
    Publication date: January 14, 2021
    Inventors: J. Paul Santerre, Sanjoy Mullick
  • Patent number: 10772992
    Abstract: A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a):(b+c) is between about 1:?21 and about 1:30, the soft tissue filler has a porosity of >75%; and a compressive moduli of between about 1 kPa and about 50 kPa.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 15, 2020
    Assignees: The Governing Council of the University of Toronto, University Health Network
    Inventors: Paul Santerre, Soror Sharifpoor, Wey Liang Leong
  • Publication number: 20200147271
    Abstract: Disclosed are vascular grafts having a surface modified to reduce the risk of thrombi formation post implantation into a subject. The vascular graft can include a tubular structure comprising a base polymer admixed with an oligofluorinated additive.
    Type: Application
    Filed: May 30, 2018
    Publication date: May 14, 2020
    Inventors: Jeannette Ho, J. Paul Santerre, Mark A. Steedman, Jamie Robert Swenor