Patents by Inventor Paul Schimmel

Paul Schimmel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210319636
    Abstract: A method in an aircraft of using prognostic indicators for aircraft maintenance includes retrieving aircraft health data for a plurality of aircraft components wherein the aircraft health data includes at least one of mechanical systems condition indicator (CI) data, vibration spectrum data, resampled time-domain (RTD) data, and RTD spectrum data. The method includes estimating component health status information for the plurality of aircraft components using a plurality of prognostic modules wherein each prognostic module is configured to generate health status information for at least one of the aircraft components, the health status information includes at least one of a current health indicator and a prognostic indicator. The method also includes storing the component health status information for the aircraft components in a database onboard the aircraft, and causing the display of the health status information for the specific component on an aircraft display.
    Type: Application
    Filed: January 22, 2021
    Publication date: October 14, 2021
    Inventors: Raj Mohan Bharadwaj, Kyusung Kim, Kwong Wing Au, Paul Frederick Dietrich, Piyush Ranade, Andrew Peter Vechart, Megan Hawley, Abraham Reddy, Craig Schimmel, David Daniel Lilly
  • Publication number: 20190381086
    Abstract: Disclosed herein are methods and compositions for inhibiting neddylation using Glycyl-tRNA synthase (GlyRS) inhibitors. Also disclosed are related compositions and methods for treating diseases such as cancer.
    Type: Application
    Filed: October 13, 2016
    Publication date: December 19, 2019
    Inventors: Xiang-Lei Yang, Zhongying Mo, Paul Schimmel
  • Publication number: 20180313836
    Abstract: Methods, compositions and kits for detecting mutated aminoacyl tRNA synthetase (aaRS) in biological samples from a subject suspect of having or suffering from a Charcot-Marie-Tooth (CMT) disease or a CMT-related disease are disclosed herein. In some embodiments, the methods include determining the amount of mutated aaRS bound to Neuropilin 1 (Nrp1). In some embodiments, methods include detection of endogenous vascular endothelial growth factor (VEGF) bound to Nrp1. Also disclosed are methods, compositions and kits for the diagnosis of a CMT or a CMT-related disease through the detection of VEGF and/or mutated aaRS in a subject.
    Type: Application
    Filed: October 13, 2016
    Publication date: November 1, 2018
    Applicant: The Scripps Research Institute
    Inventors: Xiang-Lei Yang, Na Wei, Huihao Zhou, Paul Schimmel
  • Publication number: 20160144003
    Abstract: Provided are compositions and methods for the treatment of mutant glycyl-tRNA synthetase (GlyRS)-associated diseases, such as Charcot-Marie-Tooth (CMT) diseases, and related compositions and methods for diagnostic, drug discovery, and research applications. Also provided are mutant glycyl-tRNA synthetases and uses thereof.
    Type: Application
    Filed: May 17, 2012
    Publication date: May 26, 2016
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Xiang-lei Yang, Paul Schimmel, Weiwei He
  • Patent number: 9205136
    Abstract: Methods of enhancing angiogenesis utilizing carboxy-terminal truncated human tyrosyl-tRNA synthetase (TyrRS) are disclosed. The truncated human TyrRS polypeptides comprise residues 1-364 or residues 1-343 of full length human TyrRS (SEQ ID NO: 2).
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: December 8, 2015
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Keisuke Wakasugi
  • Publication number: 20150132277
    Abstract: Isolated monomeric aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: October 9, 2014
    Publication date: May 14, 2015
    Inventors: Paul Schimmel, Xiang-Lei Yang, Bonnie Slike
  • Patent number: 8828685
    Abstract: Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: September 9, 2014
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Xiang-Lei Yang, Bonnie Slike
  • Patent number: 8796237
    Abstract: The invention provides an isolated nucleic acid encoding a polypeptide capable of inhibiting angiogenesis or neovascularization, wherein the nucleic acid comprises a first polynucleotide sequence comprising a coding sequence at least 95 percent identical to a sequence selected from the group consisting of a polynucleotide SEQ ID NO:6, a polynucleotide that encodes a polypeptide of SEQ ID NO:12, and a polynucleotide that encodes a fragment of the polypeptide of SEQ ID NO:12; and wherein the nucleic acid does not encode for the amino acid sequence of amino acids 71-93 of SEQ ID NO:1. Pharmaceutical compositions, vectors, and methods for inhibiting neovascularization or angiogenesis comprising or utilizing the nucleic acids also are provided.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: August 5, 2014
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Keisuke Wakasugi, Martin Friedlander
  • Publication number: 20140127183
    Abstract: Methods of enhancing angiogenesis utilizing carboxy-terminal truncated human tyrosyl-tRNA synthetase (TyrRS) are disclosed. The truncated human TyrRS polypeptides comprise residues 1-364 or residues 1-343 of full length human TyrRS (SEQ ID NO: 2).
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: The Scripps Research Institute
    Inventors: Paul SCHIMMEL, Keisuke WAKASUGI
  • Publication number: 20140066321
    Abstract: Provided are histidyl-tRNA synthetase variant polypeptides, X-ray crystallographic and NMR spectroscopy structures of HRS polypeptides, and related compositions and methods for therapy and drug discovery.
    Type: Application
    Filed: July 23, 2013
    Publication date: March 6, 2014
    Applicants: aTyr Pharma, Inc.
    Inventors: Zhiwen Xu, Zhiyi Wei, Xiang-Lei Yang, Mingjie Zhang, Paul Schimmel
  • Patent number: 8629253
    Abstract: Nucleic acids encoding tRNA synthetase polypeptides useful for regulating angiogenesis are disclosed. Methods of making and using such nucleic acids are also disclosed.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: January 14, 2014
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Keisuke Wakasugi
  • Patent number: 8562977
    Abstract: Pharmaceutical compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis an nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: October 22, 2013
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Keisuke Wakasugi
  • Publication number: 20130052177
    Abstract: Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: February 4, 2011
    Publication date: February 28, 2013
    Applicant: The Scripps Research Institute
    Inventors: Paul Schimmel, Xiang-Lei Yang, Bonnie Slike, Xiaoling Xu, Min Guo
  • Publication number: 20120263702
    Abstract: Pharmaceutical compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis an nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
    Type: Application
    Filed: March 30, 2012
    Publication date: October 18, 2012
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Paul SCHIMMEL, Keisuke WAKASUGI
  • Publication number: 20120238620
    Abstract: The invention provides an isolated nucleic acid encoding a polypeptide capable of inhibiting angiogenesis or neovascularization, wherein the nucleic acid comprises a first polynucleotide sequence comprising a coding sequence at least 95 percent identical to a sequence selected from the group consisting of a polynucleotide SEQ ID NO:6, a polynucleotide that encodes a polypeptide of SEQ ID NO:12, and a polynucleotide that encodes a fragment of the polypeptide of SEQ ID NO:12; and wherein the nucleic acid does not encode for the amino acid sequence of amino acids 71-93 of SEQ ID NO:1. Pharmaceutical compositions, vectors, and methods for inhibiting neovascularization or angiogenesis comprising or utilizing the nucleic acids also are provided.
    Type: Application
    Filed: September 12, 2011
    Publication date: September 20, 2012
    Inventors: Paul Schimmel, Keisuke Wakasugi, Martin Friedlander
  • Publication number: 20120122178
    Abstract: The present invention provides an isolated polypeptide comprising residues 94-471 of SEQ ID NO: 10, wherein the isolated polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO: 10. Nucleic acids and expression vectors encoding the peptide also are provided.
    Type: Application
    Filed: January 23, 2012
    Publication date: May 17, 2012
    Inventors: Paul Schimmel, Keisuke Wakasugi
  • Patent number: 8148125
    Abstract: Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
    Type: Grant
    Filed: January 17, 2011
    Date of Patent: April 3, 2012
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Keisuke Wakasugi
  • Patent number: 8101566
    Abstract: A method of suppressing angiogenesis in a mammal (e.g., for treating tumors, tumor metastasis or a condition that would benefit from decreased angiogenesis) comprises the step of administering to the mammal an angiostatically effective amount of a pharmaceutical composition comprising an isolated antiangiogenic truncated tryptophanyl-tRNA synthetase (TrpRS) polypeptide or an isolated nucleic acid that comprises a polynucleotide sequence that encodes the truncated TrpRS polypeptide. The truncated TrpRS polypeptide comprises residues 71-471 of SEQ ID NO: 10, residues 48-471 of SEQ ID NO: 10, or a polypeptide of approximately 47 kD molecular weight produced by cleavage of the polypeptide of SEQ ID NO: 10 with polymorphonuclear leucocyte elastase.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: January 24, 2012
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Keisuke Wakasugi
  • Patent number: 8017593
    Abstract: The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, which includes at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). A method for assaying the angiogenesis inhibiting activity of a composition is also provided.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: September 13, 2011
    Assignee: The Scripps Research Institute
    Inventors: Paul Schimmel, Keisuke Wakasugi, Martin Friedlander
  • Publication number: 20110110917
    Abstract: Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
    Type: Application
    Filed: January 17, 2011
    Publication date: May 12, 2011
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Paul SCHIMMEL, Keisuke WAKASUGI