Patents by Inventor Paul W. Miller

Paul W. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11471494
    Abstract: Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: October 18, 2022
    Assignee: Synlogic Operating Company, Inc.
    Inventors: Dean Falb, Jonathan W. Kotula, Vincent M. Isabella, Paul F. Miller, Suman Machinani, Saurabh Saha, Adam B. Fisher, Yves Millet, Ning Li, Jose M. Lora
  • Patent number: 11439673
    Abstract: The disclosure provides genetically engineered bacteria that are capable of reducing excess ammonia and converting ammonia and/or nitrogen into alternate byproducts. The invention also provides pharmaceutical compositions comprising the genetically engineered bacteria, and methods of modulating and treating disorders associated with excess ammonia and inflammation in the gut and the liver, including, for example, hepatic encephalopathy, NASH/NAFLD, HCV, and Huntington's disease, in a subject, comprising administering the engineered bacterium to the subject.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: September 13, 2022
    Assignee: Synlogic Operating Company, Inc.
    Inventors: Paul F. Miller, Vincent M. Isabella, Dean Falb, Jonathan W. Kotula, Yossi Dagon
  • Publication number: 20220226395
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of attenuating metabolic diseases are disclosed.
    Type: Application
    Filed: January 26, 2022
    Publication date: July 21, 2022
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Sarah Elizabeth Rowe, Yves Millet, Adam B. Fisher
  • Patent number: 11384359
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 12, 2022
    Assignee: SYNLOGIC OPERATING COMPANY, INC.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Yves Millet, Adam Fisher
  • Patent number: 7026549
    Abstract: A one-piece, molded elastomeric grommet for mounting in a hole that extends through a support panel for passing a member through the support panel has an elongate tubular portion defining a passage that extends from an inlet at one end of the tubular portion to an exit at an opposite end of the tubular portion. An umbrella portion surrounds the tubular portion and has a forward end that is integrally attached to the tubular portion so as to form an open ended acoustic chamber outwardly of the tubular portion. A mounting portion at a rearward end of the umbrella portion comprising a forward mounting flange and the umbrella portion includes a collapsible wall having a substantially uniform thickness and an undulate shape in a circumferential direction to facilitate insertion of the forward mounting flange through an undersized hole in a support panel.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: April 11, 2006
    Assignee: Delphi Technologies, Inc.
    Inventors: Dale J. Smutny, Terry L. Chapin, Masahiro Yoshino, Dale W. Kirk, Paul W. Miller
  • Patent number: 5371935
    Abstract: A method for removing a fuel cell from an aircraft fuselage cavity includes the steps of sealing the fuel cell by securing complementary covers and gaskets or O-rings in combination with the ports of the fuel cell, installing an evacuation system in combination with the fuel cell, operating the evacuation system to evacuate the sealed fuel cell wherein the ambient air pressure of the aircraft fuselage cavity collapses the fuel cell to a predetermined height, and removing the collapsed fuel cell from the aircraft fuselage cavity.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: December 13, 1994
    Assignee: United Technologies Corporation
    Inventors: Stanley Furs, Glen Grom, Paul W. Miller, David E. Wang, Arthur F. Berardi
  • Patent number: 4280671
    Abstract: A reel with an expandable mandrel support device for coiling material such as flat rolled steel strip or strips, the reel mandrel having a gripper mechanism for effectively securing each leading end to the reel mandrel which mechanism has numerous cam action gripper bars that singularly can increase gripping force as the tension in the strip strands clamped by one or more cams is developed by the reel; a positioning wedge assembly for these gripper bars constructed to first position and hold immovable, in an operative position, except for movement due to tension buildup, and secondly to positively and quickly release all gripper bars from the strand ends and hence from the reel mandrel when the coils formed by the reel mandrel are to be removed.
    Type: Grant
    Filed: May 27, 1980
    Date of Patent: July 28, 1981
    Assignee: Wean United, Inc.
    Inventors: Paul W. Miller, Norman H. Fobes
  • Patent number: 4221212
    Abstract: A method of implanting hair into skin tissue comprising the steps of forming an open loop on the end of a hair; passing the open hair loop over the tip of a needle and into hooked engagement within a notch formed in the needle periphery; inserting the needle and hair loop hooked thereto into skin tissue; releasing the hooked hair loop from the needle; and extracting the needle from the skin tissue.
    Type: Grant
    Filed: March 26, 1979
    Date of Patent: September 9, 1980
    Assignee: Hairegenics, Inc.
    Inventor: Paul W. Miller
  • Patent number: 4204413
    Abstract: The disclosure pertains to a drive shaft for machines such as roller levellers for processing steel strip. The shaft is made up of outer and inner members, the latter driving the former. Between the members is provided a frictional driving surface such as can be provided by brake lining. The inner member has an opening into which is introduced a pressure medium such as solution of soluble oil which in a controllable and predictable manner expands the inner member thereby allowing the establishment of a driving relationship between the members up to a given torque and on the experience of excessive and objectionable torques allowing relative movement between the members.
    Type: Grant
    Filed: November 8, 1977
    Date of Patent: May 27, 1980
    Assignee: Wean United, Inc.
    Inventor: Paul W. Miller
  • Patent number: 4160453
    Abstract: A method is disclosed for implanting hair into human skin comprising the steps of tieing a knot into a hair with the knot defining an interstice through which skin tissue may subsequently grow thereby anchoring the hair firmly in place, loading a needle by placing the hair knot in a hollow end of the needle and extending the hair from the knot through a notch formed in a surface of the needle end, inserting the loaded needle into the skin, and extracting the needle from the skin.Apparatus is also disclosed for implanting hair having a bulbous end into human skin which apparatus comprises a tubular needle having a beveled end providing a pointed tip for piercing the skin and a notch formed in the beveled end through which the hair may extend with the bulbous hair end held within the tubular needle in engagement with an inner surface of the needle adjacent the beveled end notch.
    Type: Grant
    Filed: September 6, 1977
    Date of Patent: July 10, 1979
    Assignee: Hairegenics, Inc.
    Inventor: Paul W. Miller
  • Patent number: 4126124
    Abstract: A method is disclosed for implanting hair into human skin comprising the steps of tieing a knot into a hair with the knot defining an interstice through which skin tissue may subsequently grow thereby anchoring the hair firmly in place, loading a needle by placing the hair knot in a hollow end of the needle and extending the hair from the knot through a notch formed in a surface of the needle end, inserting the loaded needle into the skin, and extracting the needle from the skin.Apparatus is also disclosed for implanting hair having a bulbous end into human skin which apparatus comprises a tubular needle having a beveled end providing a pointed tip for piercing the skin and a notch formed in the beveled end through which the hair may extend with the bulbous hair end held within the tubular needle in engagement with an inner surface of the needle adjacent the beveled end notch.
    Type: Grant
    Filed: September 6, 1977
    Date of Patent: November 21, 1978
    Assignee: Hairegenics, Inc.
    Inventor: Paul W. Miller
  • Patent number: 3998230
    Abstract: A method is disclosed for implanting hair into human skin comprising the steps of inserting an end of a hollow outer needle into skin to form a pit in the surface thereof, sliding an inner needle within the outer needle to position an end of the inner needle supporting a bulbous end of a hair within the skin pit adjacent the end of the outer needle, and extracting the outer and inner needles from the skin pit.Apparatus is also disclosed for implanting hair into human skin which apparatus comprises a hollow outer needle having a relatively sharp end for piercing skin, a hollow inner needle slidably disposed within the hollow outer needle and having a centrally apertured relatively blunt end for receiving a hair therethrough and for supporting a bulbous hair end on the surface thereof, and means for moving the inner needle blunt end between positions remote and positions closely adjacent the outer needle sharp end.
    Type: Grant
    Filed: October 22, 1974
    Date of Patent: December 21, 1976
    Assignee: Hairegenics, Inc.
    Inventor: Paul W. Miller