Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: The use of natural language to query a database (e.g., storing performance data for an industrial system) is hindered by the use of non-semantic names for database elements in databases. While these non-semantic names could be modified, this requires modifying the databases, as well as modifying the applications that utilize the databases. Accordingly, embodiments disclosed herein train and apply a text-to-SQL model that translates natural-language queries into Structured Query Language (SQL) queries that utilize semantic names for database elements. These SQL queries utilize database views that map the native names for database elements to their semantic names. In addition, domain-specific pre-processing may be performed on the inputs to the text-to-SQL model. Collectively, this improves the accuracy of the text-to-SQL translation, without having to modify the databases or applications, while also enabling voice-based natural-language queries.

Abstract: Described are techniques for corroborating anomalous behavior. The techniques include training devices included in an Internet of Things (IoT) mesh network to independently identify occurrences of anomalous behavior in a proximate physical environment. The techniques further include receiving event data from at least a portion of the devices in the IoT mesh network corresponding to a time window, where the event data reports occurrences of at least one type of anomalous behavior. The techniques further include corroborating the at least one type of anomalous behavior to determine that the occurrences of the at least one type of anomalous behavior indicate an anomalous event that meets a reporting threshold for providing notice of the anomalous event. The techniques further include generating a notification regarding the anomalous event.

Abstract: Aspects of the present disclosure relate to systems and methods for detecting emerging events. In various examples, a method for detecting emerging events includes obtaining communication data associated with communication between multiple sources, segmenting communication data into multiple segments, determining whether a data segment belongs to a familiar topic or none, and generating a notification when a familiar topic is mentioned for more or less than a mention prediction. Additionally, or alternatively, a notification may be generated when an unfamiliar topic emerges from a set of unfamiliar data segments if an associated segment count exceeds a critical mass threshold. To determine whether a data segment belongs to a familiar topic, the data segment may be transformed into a feature vector and mapped onto a feature space, where a distance-based similarity score may be determined.

Abstract: Embodiments described herein include apparatuses, computer program products, and methods for data management in a group-based communication system. Specifically, some embodiments address data management for group-based communication channel(s) accessible to any number of entities based on various data retention policies. In this regard, embodiments enable maintenance of data associated with multiple organizations accessing a group-based communication channel based on a single, shared data retention policy, or different data retention policies, for example based on authorship of the group-based communication message. In embodiments, a data retention policy may be assigned directly to an entity, or assigned to a higher-level or lower-level entity and function as a default data a retention policy for other entities associated therewith.

Abstract: Disclosed herein are computer-implemented devices, systems, and methods of sanitizing a transcript. In an example, such a method includes selecting a transcript to be sanitized, identifying potential redactions to be made in the transcript, and redacting the transcript at the potential redactions to sanitize the transcript. The potential redactions are identifiable via a multi-pass process that includes: generating initial redactions to be made based on surrounding context within the transcript; generating matching redactions to be made based on the initial redactions, and generating character redactions to be made based on at least one of the initial redactions and the matching redactions.

Abstract: A single acting actuator for an aircraft landing gear assembly is disclosed having a piston mounted in a cavity and moveable relative to a housing between a retracted position and an extended position, the piston dividing the cavity into first and second pressure chambers. At least one of the pressure chambers is associated with first and second outlets, with the actuator being arranged such that, in respect of the relative movement in which the pressure chamber is the decreasing volume pressure chamber, in a first stage of the relative movement the first and second outlets are open thereby allowing actuator fluid to flow out of the pressure chamber through the first and second outlets and in a second stage of the relative movement the second outlet is open but the first outlet is closed, thereby acting to slow the relative movement of the piston with respect to the housing.

Abstract: A process for refining a crude ethylene glycol stream comprising monoethylene glycol and at least one acid contaminant is disclosed. The process comprises reacting the acid contaminant with the monoethylene glycol in at least one reaction zone to form an ester and removing the ester in a separation step.

Abstract: A system, apparatus, and method for encoding and decoding a video image having a plurality of frames is disclosed. Encoding and decoding the video image can include selecting, for a current block, a prediction mode from a plurality of prediction modes; identifying, for the current block, a quantization value; selecting, for the current block, a probability distribution from a plurality of probability distributions based on the identified quantization value using a processor; and entropy encoding the selected prediction mode using the selected probability distribution.

Abstract: Systems and methods are provided for generating quality scores associated with a contact (e.g., a telephonic call including an agent) and with agents. In particular, the disclosed technology determines types of frames of content of the contact into a speech and/or a noise, the noise further classified into a standard noise and a non-standard noise. A frame type determiner determines a type of a frame based on a waveform analysis and/or use of speech and noise models that are trained through machine learning. The standard noise includes noise that is expected and consistent across contacts and agents (e.g., a hold music). The non-standard noise includes a noise that is unexpected in occasion and audio sources (e.g., a barking dog, a siren from street, and the like). The disclosed technology enables assessing contacts and agents based on issues associated with remote working environment that vary among agents.

Abstract: Aspects of the present disclosure relate to systems and methods for detecting emerging events. In various examples, a method for detecting emerging events includes obtaining communication data associated with communication between multiple sources, segmenting communication data into multiple segments, determining whether a data segment belongs to a familiar topic or none, and generating a notification when a familiar topic is mentioned for more or less than a mention prediction. Additionally, or alternatively, a notification may be generated when an unfamiliar topic emerges from a set of unfamiliar data segments if an associated segment count exceeds a critical mass threshold. To determine whether a data segment belongs to a familiar topic, the data segment may be transformed into a feature vector and mapped onto a feature space, where a distance-based similarity score may be determined.

Abstract: Systems and methods are provided for determining a rapport score for a contact. Data associated with a contact may include an audio recording, a transcript, metadata, and/or other contact data collected during or generated after a contact. One or more rapport models are applied to the contact data to generate rapport metrics that capture one aspect of the rapport during a contact. Rapport metrics can be compared to target rapport metrics to determine whether the rapport metric indicates positive rapport during the contact. From rapport metrics, a rapport score can be generated that indicates the overall rapport for the contact. Rapport metrics, rapport scores, and other information associated with a contact can be provided in a manner that allows for useful evaluation of whether contact participants developed positive rapport during a contact and/or a series of contacts over time.

Abstract: The present disclosure relates to generating additional insight data for search results. Individual search results may be obtained and used to generate a parse tree for the search result data. A dependency graph may then be generated using the parse tree, where the dependency graph includes a root node that corresponds to a query parameter. A scoring or weighting algorithm is applied to the dependency graph to generate and aggregate scores for nodes in the dependency graph relative to the root node. The generated scores or weights are used to generate insight data for the search results.

Abstract: A biometric status sensing media therapy system for the therapeutic care of a Consumer. The system has a media therapy device provided with a central processing unit, audio and/or visual input/output and wireless communications. The media therapy device is provided in wireless communication with a cloud computing and data storage resource. A collection of media files, transmitted to the media therapy device from the cloud computing and data storage resource for play by the media therapy device, is played by the media therapy device according to a pre-configured collection of rules based upon a time schedule and/or a biometric status of the consumer.

Abstract: Systems and methods are provided for determining calls and contacts associated with calls that are contextually similar based on content of the calls. Data associated with a call include one or more utterances made by speakers and a set of values indicating relevance between content of the call and topic categories of the call. The disclosed technology generates a topic vector associated with a call and/or respective speakers of the call. The topic vector includes a multidimensional vector where each dimension corresponds to a topic category. The disclosed technology determines calls that are contextually similar by comparing angular distances between topic vectors. A search query receiver receives a search query that queries contacts and calls that are contextually similar to a given call and/or a speaker. The disclosed technology identifies calls with topic vectors that are within a predetermined angular distance.

Abstract: Systems and methods are provided for generating call sentiment associated with a call. The call includes one or more utterances. An utterance includes one or more sentences. A sentence includes one or more words. The disclosed technology iteratively generates sentiment values associated with sentences based on sentiment associated with words in the sentences, sentiment values associated with utterances based on sentence sentiment, and the call sentiment. Determining sentiment includes use of one or more a trained neural network for predicting sentiment and weighted average of sentiment values associated sentences and utterances for aggregating sentiment values. The disclosed technology generates a sentiment momentum that trends sentiment that evolves over time during the call. A speaker sentiment indicates sentiment associated with a speaker who makes utterance during the call.

Abstract: Disclosed herein are computer-implemented devices, systems, and methods for sanitizing an audio recording of a conversation. In an example, such a computer-implemented method can include selecting a transcript of the conversation. The transcript can include a plurality of redaction markers within the audio recording. The plurality of redaction markers can be identifiable via one or more redaction marker start and/or end points. The computer-implemented method can include identifying a first redaction marker and a second redaction marker of the one or more redaction markers. The first redaction marker can be different from the second redaction marker. In this regard, a redaction segment is formable between the first and second redaction markers. The computer-implemented method can include selecting the audio recording. The computer-implemented method can include redacting the audio recording between the first redaction marker and the second redaction marker.

Abstract: Generating, by a processor in response to instructions stored on a non-transitory computer readable medium, a reconstructed frame, may include generating a reconstructed block of the reconstructed frame by decoding from an encoded bitstream. Decoding may include decoding a value from the encoded bitstream, identifying, in accordance with the value, a probability distribution for generating the reconstructed block, wherein the value indicates the probability distribution among a plurality of probability distributions determined independently of generating the reconstructed frame, entropy decoding an encoded prediction mode from the encoded bitstream using the probability distribution to identify a prediction mode for generating the reconstructed block, generating a prediction block in accordance with the prediction mode; combining the prediction block and a reconstructed residual block to obtain the reconstructed block, and including the reconstructed block in the reconstructed frame.

Abstract: A retractable landing gear on an aircraft is operated by a landing gear control system 20 having a manually operable lever 26 movable from a first, e.g. gear-down, position to a second, e.g. gear-up position, in response to which a signal (e.g. a gear-up command) is outputted causing the landing gear to move to an up position. The landing gear control system 20 also includes a motor 40 configured to move the lever 26 in dependence on a signal, for example a signal received by a landing gear lever control unit 42 from a take-off detection system 46 which indicates that the aircraft has taken-off. Thus, the lever 26 may be considered as being configured both to be operated by a pilot of the aircraft manually and to be operated by the motor automatically.