Patents by Inventor Paula Hammond

Paula Hammond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230210968
    Abstract: Disclosed herein is a non-covalent complex, comprising: a tetramer of a recombinant protein; and an agonist of a Stimulator of Interferon Gene (STING) protein or a pharmaceutically acceptable salt thereof, wherein the recombinant protein comprises a STING protein lacking a transmembrane domain (STING?TM protein). Additionally, provided is a vaccine composition, comprising a non-covalent complex and a pharmaceutically acceptable carrier, wherein the non-covalent complex comprises: a recombinant protein comprising a STING?TM protein and a tumor epitope; and an agonist of a STING protein or a pharmaceutically acceptable salt thereof. Further provided are methods of treating and preventing cancer using the disclosed complexes, pharmaceutical compositions, and vaccines.
    Type: Application
    Filed: June 11, 2021
    Publication date: July 6, 2023
    Inventors: Paula HAMMOND, Yanpu HE, Jiahe LI
  • Publication number: 20220233576
    Abstract: SLC46A3 has been identified as a lipid-based nanoparticle-specific biomarker predictive of nanoparticle-cancer cell affinity. SLC46A3 has a strong inverse association with lipid-based nanoparticle uptake across multiple nanoparticle formulations. Tissues with decreased expression levels of SLC46A3 have a greater uptake of lipid-based nanoparticles. The inverse relationship of SLC46A3 expression in tumor tissue and affinity for lipid-based nanoparticles has therapeutic and diagnostic implications, including cancer therapy and diagnosis, and identification of patients most likely to benefit from a lipid-based nanotherapeutic for improved stratification in clinical trials.
    Type: Application
    Filed: January 24, 2022
    Publication date: July 28, 2022
    Inventors: Natalie BOEHNKE, Joelle Payne STRAEHLA, Angela KOEHLER, Paula HAMMOND
  • Publication number: 20200292944
    Abstract: Customizable hydrogel patterned into arrays of microwells, microchannels, or other microfeatures, and a process to prepare patterned hydrogel adherent to a solid support, are provided. A pattern of light is applied to photopolymerizable hydrogel precursor solution on a solid support, resulting in the formation of a patterned hydrogel bonded to the solid support. Hydrogel precursor solution is held by a ring of a customized height secured to a photomask or to a surface allowing transmission of a pattern of light. This process allows for facile customization and repeated fabrications of hydrogel microwells of desired heights and geometries with a micron or submicron scale resolution, adherent on various solid supports.
    Type: Application
    Filed: November 17, 2016
    Publication date: September 17, 2020
    Inventors: Marianna Sofman, Natasha Arora, Linda Griffith, Paula Hammond
  • Patent number: 9070932
    Abstract: A self-supporting carbon electrode can include, or consist essentially of, nanostructured carbon, for example, oxygen-functionalized nanostructured carbon.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 30, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Hye Ryung Byon, Seung Woo Lee, Betar Gallant, Yang Shao-Horn, Paula Hammond, Nasim Hyder
  • Publication number: 20130089790
    Abstract: A self-supporting carbon electrode can include, or consist essentially of, nanostructured carbon, for example, oxygen-functionalized nanostructured carbon.
    Type: Application
    Filed: October 11, 2011
    Publication date: April 11, 2013
    Inventors: Hye Ryung Byon, Seung Woo Lee, Betar Gallant, Yang Shao-Horn, Paula Hammond, Nasim Hyder
  • Publication number: 20090088679
    Abstract: A decomposable thin film comprising a plurality of alternating layers of net positive and negative charge. At least a portion of the positive layers, the negative layers, or both, comprise a polyelectrolyte.
    Type: Application
    Filed: February 7, 2006
    Publication date: April 2, 2009
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Kris Wood, Nicole Zacharia, Paula Hammond Cunningham, Dean Delongchamp
  • Publication number: 20080226739
    Abstract: A linear-dendritic hybrid polymer for encapsulating biologically active materials. The hybrid polymer includes a ligand for a predetermined target, a dendron, and a polyethylene glycol (PEG) chain linking the ligand to the dendron.
    Type: Application
    Filed: June 22, 2006
    Publication date: September 18, 2008
    Inventors: Kris C. Wood, Paula Hammond Cunningham, Steven Little, Robert Langer
  • Publication number: 20060062982
    Abstract: One aspect of the invention provides ion-exchange and gas-diffusion membranes, fabricated by a layer-by-layer approach, for use, e.g., in electrochemical cells; a process for making membrane electrode assemblies fabricated using porous frameworks, LBL composite membranes and LBL carbon-Polymer electrodes; and the application of the membrane and electrode assemblies to a variety of devices, both electrochemical and otherwise.
    Type: Application
    Filed: September 17, 2004
    Publication date: March 23, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Paula Hammond Cunningham, Tarek Farhat
  • Publication number: 20050244898
    Abstract: One aspect of the present invention relates to an array of non-adhesive cells, comprising a polymeric substrate, an array of a graft copolymer bound to the polymeric substrate, an antibody bound to the polymeric substrate in an area of the polymeric substrate not covered by the graft copolymer, and a non-adhesive cell bound to the antibody. Another aspect of the present invention relates to a method of preparing an array of non-adhesive cells, comprising depositing an array of a graft copolymer upon a polymeric substrate; binding an antibody to an area of the polymeric substrate not covered by the graft copolymer; and binding a non-adhesive cell to the antibody.
    Type: Application
    Filed: November 15, 2004
    Publication date: November 3, 2005
    Inventors: Robert Cohen, Paula Hammond-Cunningham, Darrell Irvine, Heejae Kim, Junsang Doh