Patents by Inventor Pedro Talavera Escasany

Pedro Talavera Escasany has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8188285
    Abstract: It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consisting of tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, and L-(+)-?-phenylglycinol salt, in the presence of an appropriate solvent. It also comprises novel salts of Montelukast, in particular, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, and L-(+)-?-phenylglycinol salts.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: May 29, 2012
    Assignee: Esteve Quimica, S.A.
    Inventors: Yolanda Gasanz Guillén, Pedro Talavera Escasany, Montserrat Monsalvatje Llagostera
  • Publication number: 20100029945
    Abstract: It relates to a process for the purification of Montelukast, or pharmaceutically salts thereof, or solvates thereof, including stereoisomers or mixture thereof which comprises carrying out a specific set of selective solvent extractions of Montelukast or its impurities in a mixture of an organic solvent and water at specific ranges of pH and temperature which depend on the type of impurities to remove. In particular, it comprises at least one wash of an aqueous phase containing crude Montelukast in salt form with an organic solvent, at a pH comprised between 12.0 and 13.5; and optionally one or more washes of the resulting aqueous phase with an organic solvent at a pH comprised between 8.5 and 10.0. Montelukast is recovered by acidification at a pH comprised between 4.5 and 8.0 and solvent extraction, and is isolated either as acid or in salt form.
    Type: Application
    Filed: August 7, 2007
    Publication date: February 4, 2010
    Applicant: ESTEVE QUÍMICA, S.A.
    Inventors: Yolanda Gasanz Guillén, Pedro Talavera Escasany, Montserrat Monsalvatje Llagostera
  • Publication number: 20090247759
    Abstract: It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consisting of tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, and L-(+)-?-phenylglycinol salt, in the presence of an appropriate solvent. It also comprises novel salts of Montelukast, in particular, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, and L-(+)-?-phenylglycinol salts.
    Type: Application
    Filed: August 7, 2007
    Publication date: October 1, 2009
    Applicant: ESTEVE QUIMICA, S.A.
    Inventors: Yolanda Gasanz Guillen, Montserrat Monsalvatje Llagostera, Pedro Talavera Escasany
  • Publication number: 20080306270
    Abstract: It comprises a preparation process of Montelukast from a new intermediate compound of formula (VI), which is previously prepared by reaction of the corresponding sulfonate with 1-(mercaptomethyl)cyclopropyl)methanol. Compound (VI) is reacted with a Grignard reactant to convert the ester group into a tertiary alcohol, followed by conversion of the primary alcohol into a sulfonate, substitution of the sulfonate group by a cyano group, and finally transforming the cyano compound to the carboxilic acid compound by a hydrolysis reaction to afford Montelukast. Montelukast can also be prepared by a hydrolysis reaction of the corresponding amide. It also comprises new intermediate compounds useful in such preparation process.
    Type: Application
    Filed: November 3, 2006
    Publication date: December 11, 2008
    Applicant: ESTEVE QUÍMICA, S.A.
    Inventors: Laura Coppi, Marti Bartra Sanmarti, Yolanda Gasanz Guillen, Montserrat Monsalvatje Llagostera, Pedro Talavera Escasany