Abstract: The present invention relates to a pharmaceutical composition comprising a sulfonamide as an inhibitor of Bcl-2/Bcl-xL, especially compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoromethyl sulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester or a pharmaceutically acceptable salt thereof and suitable excipients, preferably a pharmaceutical composition in the form of a lyophilized powder. The invention also relates to a method for preparing the pharmaceutical composition.

Abstract: Described herein are modified isopropylmalate synthase nucleic acids and proteins, as well as methods, plants, plant cells, and seeds that include the modified isopropylmalate synthase. As shown herein, plants and seeds with such modified isopropylmalate synthase nucleic acids and proteins have increased biomass and/or increased amino acid content.

Abstract: An improved method for manufacturing a continuous self-healing barrier film is provided. The method includes slot-die coating opposing sides of a separator substrate with a curing agent slurry and a curable resin slurry using a single-sided coating line or a tandem coating line. The method also includes sequentially interleaving inner and outer protective layers via a continuous roll-to-roll process to create a multi-layered barrier film. The barrier film can optionally be formed into a barrier envelope, and an insulating core material can be inserted into the barrier envelope to define an enclosure. Evacuating and sealing the enclosure along a perimeter of the barrier envelop forms a self-healing vacuum insulation panel with excellent properties for use as a building material and in refrigeration systems, for example. The barrier film can alternatively be used in the manufacture of tires, roofing, cargo containers, food packaging, and pharmaceutical packaging, for example.

Abstract: A joint sealing system for prefabricated building components is provided. The joint sealing system includes a first component including a first surface, and a second component including a second surface that is mateable with the first surface. The first and second surfaces define a joint. A sealant composition is disposed on one of the first surface or the second surface. Pressure exerted when the second surface is mated with the first surface triggers curing of the sealant composition to join the first and second components and to seal the joint between the first and second components. A method of joining and sealing two prefabricated building components is also provided.

Abstract: Provided are a MoSxOy/carbon nanocomposite material, a preparation method therefor and a use thereof. In the MoSxOy/carbon nanocomposite material, 2.5?x?3.1, 0.2?y?0.7, and the mass percent of MoSxOy is 5%-50% based on the total mass of the nanocomposite material. When the MoSxOy/carbon nanocomposite material is used as a catalyst for an electrocatalytic hydrogen evolution reaction, the current density is 150 mA/cm2 or more at an overpotential of 300 mV. The difference between this performance and the performance of a commercial 20% Pt/C catalyst is relatively small, or even equivalent; and this performance is far better than the catalytic performance of an existing MOS2 composite material. The MoSxOy/carbon nanocomposite material also has a good catalytic stability, and after 8,000 catalytic cycles, the current density thereof is only decreased by 3%, thus exhibiting a very good catalytic performance and cycle stability.

Abstract: A self-healing vacuum insulation panel and a method of manufacture are provided. The vacuum insulation panel includes a self-healing, multi-layer barrier film including a separator between a curing agent and a curable resin. Upon damage to the separator, the curing agent penetrates the separator due to a pressure differential across the barrier film and reacts with the curable resin to seal any cuts or punctures. The curing agent and the curable resin can be selected to have long term stability and a short reaction time with no need for external stimuli. As a result, the multi-layer barrier film can retain the internal vacuum and maintain a desirably low thermal conductivity using low-cost, commercially available epoxies and curing agents.

Abstract: A MoSx/carbon black nanocomposite material, and a manufacturing method and application thereof. In the MoSx/carbon black nanocomposite material, 2?x?2.3. The weight percentage of MoSx as part of the total weight of the nanocomposite material is 5-50%. The MoSx/carbon black nanocomposite material has 20% higher performance when compared to a commercial 20% Pt/C catalyst. The manufactured MoSx/carbon black nanocomposite material also has excellent catalytic stability. There is no significant decrease in catalytic performance of the material after 5,000 catalytic cycles.

Abstract: The present invention relates to a pharmaceutical composition comprising a sulfonamide as an inhibitor of Bcl-2/Bcl-xL, especially compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoromethyl sulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester or a pharmaceutically acceptable salt thereof and suitable excipients, preferably a pharmaceutical composition in the form of a lyophilized powder. The invention also relates to a method for preparing the pharmaceutical composition.

Abstract: A self-healing adhesive composition comprising a homogeneous mixture of: (i) a self-healing polymer containing hydrogen bonding groups or long-chain alkyl groups, wherein said hydrogen bonding groups comprise hydrogen bond donating groups and hydrogen bond accepting groups, and wherein said long-chain alkyl groups contain at least four carbon atoms; and (ii) an extrudable adhesive polymer base having a curable property and no self-healable property; wherein component (i) is present in the self-healing adhesive composition in an amount of at least 10 wt % and up to 70 wt % of the total of components (i) and (ii). Also described herein is a method of sealing a space (e.g., crack, gap, or pores) in a substrate material by at least partially filling the space with the self-healing adhesive composition described above and permitting the self-healing adhesive composition to harden over time without applying an external stimulus to induce hardening.

Abstract: An elastic composition comprising the following structure: wherein: PDMS is polydimethylsiloxane having at least 5 dimethylsiloxane units; L is a bond or hydrocarbon linker; the asterisk (*) in A units denotes a connection point with an asterisk in B units, and at least one of the following linkages connect between connection points: r is an integer of at least 3; R is a hydrocarbon or siloxane-containing linking moiety; the composition includes a multiplicity of A units and multiplicity of B units; and a portion of the connection points are necessarily terminated by endcapping groups, wherein at least a portion of the endcapping groups are selected from the following structures: The invention also includes methods for making and using the above-described elastic composition.

Abstract: A graft copolymer composition comprising the following structure: wherein: Ax represents a polymer backbone having a number of polymerized monomer units x; [By] represents a multiplicity of a graft polymer side chain having a number of polymerized monomer units y, and at least a portion of the monomer units in By contains a group —C(O)OM, with M independently selected from H and alkali metals; [C] represents a multiplicity of positions on the polymer backbone Ax where the graft polymer side chain B or any other graft polymer side chain is not attached; the subscript w represents a grafting density of the group By, wherein w is an integer within a range of 10-50%; and the subscript z represents a density of the group C, wherein z=(100?w) %. The invention is also directed to lithium-ion batteries in which the above-described composition is incorporated in an anode of the battery.

Abstract: A crosslinked polymer composition comprising: (i) a base polymer containing a multiplicity of at least one type of functional group selected from amino, amido, thiol, carboxylic acid, carboxylic acid ester, and epoxy groups; (ii) a multiplicity of hydroxylated benzene rings covalently linked to the base polymer, wherein each hydroxylated benzene ring contains at least two hydroxy groups, and with at least two of the hydroxy groups on said hydroxylated benzene rings being free as OH groups; and (iii) a multiplicity of crosslinking groups that crosslink at least two of said functional groups in the base polymer. The invention is also directed to lithium-ion batteries in which the above-described composition is incorporated in an electrode of the battery, and also directed to methods of operating a lithium-ion battery in which the above-described crosslinked polymer composition is incorporated in an electrode thereof.

Abstract: An improved method for manufacturing a continuous self-healing barrier film is provided. The method includes slot-die coating opposing sides of a separator substrate with a curing agent slurry and a curable resin slurry using a single-sided coating line or a tandem coating line. The method also includes sequentially interleaving inner and outer protective layers via a continuous roll-to-roll process to create a multi-layered barrier film. The barrier film can optionally be formed into a barrier envelope, and an insulating core material can be inserted into the barrier envelope to define an enclosure. Evacuating and sealing the enclosure along a perimeter of the barrier envelop forms a self-healing vacuum insulation panel with excellent properties for use as a building material and in refrigeration systems, for example. The barrier film can alternatively be used in the manufacture of tires, roofing, cargo containers, food packaging, and pharmaceutical packaging, for example.

Abstract: A self-healing vacuum insulation panel and a method of manufacture are provided. The vacuum insulation panel includes a self-healing, multi-layer barrier film including a separator between a curing agent and a curable resin. Upon damage to the separator, the curing agent penetrates the separator due to a pressure differential across the barrier film and reacts with the curable resin to seal any cuts or punctures. The curing agent and the curable resin can be selected to have long term stability and a short reaction time with no need for external stimuli. As a result, the multi-layer barrier film can retain the internal vacuum and maintain a desirably low thermal conductivity using low-cost, commercially available epoxies and curing agents.

Abstract: A polymer construct includes at least one extruded degradable polymer layer having a host polymer material and at least one amphiphilic star-shaped polymer miscible with the host polymer material. The star-shaped polymer includes a polymer core and polymer branches extending therefrom to define a shell around the core. A guest agent is loaded on and/or within the core. The polymer construct upon delivery to a site of interest provides controlled and/or sustained release of the guest agent upon degradation of the at least one polymer layer.

Abstract: An elastic composition comprising the following structure: wherein: PDMS is polydimethylsiloxane having at least 5 dimethylsiloxane units; L is a bond or hydrocarbon linker; the asterisk (*) in A units denotes a connection point with an asterisk in B units, and at least one of the following linkages connect between connection points: r is an integer of at least 3; R is a hydrocarbon or siloxane-containing linking moiety; the composition includes a multiplicity of A units and multiplicity of B units; and a portion of the connection points are necessarily terminated by endcapping groups, wherein at least a portion of the endcapping groups are selected from the following structures: The invention also includes methods for making and using the above-described elastic composition.

Abstract: A crosslinked polymer composition comprising: (i) a base polymer containing a multiplicity of at least one type of functional group selected from amino, amido, thiol, carboxylic acid, carboxylic acid ester, and epoxy groups; (ii) a multiplicity of hydroxylated benzene rings covalently linked to the base polymer, wherein each hydroxylated benzene ring contains at least two hydroxy groups, and with at least two of the hydroxy groups on said hydroxylated benzene rings being free as OH groups; and (iii) a multiplicity of crosslinking groups that crosslink at least two of said functional groups in the base polymer. The invention is also directed to lithium-ion batteries in which the above-described composition is incorporated in an electrode of the battery, and also directed to methods of operating a lithium-ion battery in which the above-described crosslinked polymer composition is incorporated in an electrode thereof.

Abstract: A MoSx/carbon black nanocomposite material, and a manufacturing method and application thereof. In the MoSx/carbon black nanocomposite material, 2?x?2.3. The weight percentage of MoSx as part of the total weight of the nanocomposite material is 5-50%. The MoSx/carbon black nanocomposite material has 20% higher performance when compared to a commercial 20% Pt/C catalyst. The manufactured MoSx/carbon black nanocomposite material also has excellent catalytic stability. There is no significant decrease in catalytic performance of the material after 5,000 catalytic cycles.

Abstract: Provided are a MoSxOy/carbon nanocomposite material, a preparation method therefor and a use thereof. In the MoSxOy/carbon nanocomposite material, 2.5?x?3.1, 0.2?y?0.7, and the mass percent of MoSxOy is 5%-50% based on the total mass of the nanocomposite material. When the MoSxOy/carbon nanocomposite material is used as a catalyst for an electrocatalytic hydrogen evolution reaction, the current density is 150 mA/cm2 or more at an overpotential of 300 mV. The difference between this performance and the performance of a commercial 20% Pt/C catalyst is relatively small, or even equivalent; and this performance is far better than the catalytic performance of an existing MOS2 composite material. The MoSxOy/carbon nanocomposite material also has a good catalytic stability, and after 8,000 catalytic cycles, the current density thereof is only decreased by 3%, thus exhibiting a very good catalytic performance and cycle stability.

Abstract: A graft copolymer composition comprising the following structure: wherein: Ax represents a polymer backbone having a number of polymerized monomer units x; [By] represents a multiplicity of a graft polymer side chain having a number of polymerized monomer units y, and at least a portion of the monomer units in By contains a group —C(O)OM, with M independently selected from H and alkali metals; [C] represents a multiplicity of positions on the polymer backbone Ax where the graft polymer side chain B or any other graft polymer side chain is not attached; the subscript w represents a grafting density of the group By, wherein w is an integer within a range of 10-50%; and the subscript z represents a density of the group C, wherein z=(100?w) %. The invention is also directed to lithium-ion batteries in which the above-described composition is incorporated in an anode of the battery.