Patents by Inventor Percy Sarwood Manchand

Percy Sarwood Manchand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing substituted isoquinolines
    Patent number: 8877929
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: November 4, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Percy Sarwood Manchand
  • Process for synthesizing substituted isoquinolines
    Patent number: 8357806
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: January 22, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza
  • Process for Synthesizing Substituted Isoquinolines
    Publication number: 20120220774
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Application
    Filed: May 10, 2012
    Publication date: August 30, 2012
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza
  • Process or synthesizing substituted isoquinolines
    Patent number: 8207341
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: June 26, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Percy Sarwood Manchand, Hyungcheol Kim, Sangsoo Lee, Chunyoung Kim, Soonha Yang, Eunhee Choi
  • Process for Synthesizing Substituted Isoquinolines
    Publication number: 20100056792
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 4, 2010
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza, Hyungcheol Kim, Sangsoo Lee, Chunyoung Kim, Soonha Yang, Eunhee Choi
  • 1,3-dihydroxy-20,20-dialkyl-vitamin D3 analogs
    Publication number: 20040167105
    Abstract: This invention relates to 1,3-dihydroxy-20,20-dialkyl-vitamin D3 analogs of Formula (I): 1
    Type: Application
    Filed: February 18, 2004
    Publication date: August 26, 2004
    Inventors: Percy Sarwood Manchand, Milan Radoje Uskokovic
  • 1,3-dihydroxy-20,20-cycloalkyl-vitamin D3analogs
    Patent number: 6492353
    Abstract: This invention relates to 1,3-dihydroxy-20,20-dialkyl-vitamin D3 analogs of Formula (I): compositions comprising the analogs, methods of preparing the analogs and methods of treatment of osteoporosis, secondary hyperparathyroidism, cancer and autoimmune diseases using such analogs.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: December 10, 2002
    Assignees: Syntex LLC, Hoffmann-La Roche Inc.
    Inventors: Percy Sarwood Manchand, Milan Radoje Uskokovic
  • Synthesis of 3-epi vitamin D.sub.3 metabolites and analogs
    Patent number: 6040461
    Abstract: The invention relates to a process for the preparation of vitamin D.sub.3 compounds of formula I. ##STR1## Wherein A is a single or a double bond; B is a single, cis-double, trans double or a triple bond; R.sub.1 and R.sub.2 are independently hydrogen, a lower alkyl, e.g., a C.sub.1 -C.sub.4 alkyl; R.sub.3 and R.sub.4 are independently a lower alkyl, e.g., C.sub.1 -C.sub.4 alkyl, a hydroxyalkyl, and a haloalkyl, e.g., a fluoroalkyl; and X and Y are independently hydrogen or hydroxy in the case when B is a single or a double bond.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: March 21, 2000
    Assignees: Hoffmann-La Roche Inc., Syntex (U.S.A.)
    Inventors: Andrew David Batcho, Percy Sarwood Manchand, Milan Radoje Uskokovic
  • Vitamin D.sub.3 analogs with bis C-20 side chains
    Patent number: 6030962
    Abstract: This invention provides Vitamin D.sub.3 analogs of the Formula I ##STR1## wherein: X is H.sub.2 or CH.sub.2 ;Y is hydrogen, hydroxy or fluorine;Z is hydroxy;R.sub.1 and R.sub.2 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.1 and R.sub.2 together with C.sub.25 form a (C.sub.3 -C.sub.6) cycloalkyl or cyclofluoroalkyl;R.sub.3 and R.sub.4 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.3 and R.sub.4 together with C.sub.25, form a (C.sub.3 -C.sub.6)cycloalkyl or cyclofluoroalkyl;A is a single bond or a double bond;B.sub.1 is a single bond, an E-double bond, a Z-double bond or a triple bond; andB.sub.2 is a single bond, an E-double bond, a Z-double bond or a triple bond; and prodrugs thereof, intermediates and methods for preparation of these analogs, pharmaceutical compositions containing such analogs and methods for treatment of osteoporosis, hyperparathyroidism and autoimmune diseases.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: February 29, 2000
    Assignee: Synttex (U.S.A.) Inc.
    Inventors: Percy Sarwood Manchand, Milan Radoje Uskokovic
  • Method of using vitamin D.sub.3 analogs with bis C-20 side chains
    Patent number: 6008209
    Abstract: This invention provides a method of treating or preventing neoplastic diseases. The method comprises adminstering to a host in need of such treatment or prevention an effective amount of a Vitamin D.sub.3 analog of the Formula I wherein:X is H.sub.2 or CH.sub.2 ;Y is hydrogen, hydroxy or fluorine;Z is hydroxy;R.sub.1 and R.sub.2 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.1 and R.sub.2 together with C.sub.25 form a (C.sub.3 -C.sub.6) cycloalkyl or cyclofluoroalkyl;R.sub.3 and R.sub.4 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.3 and R.sub.4 together with C.sub.25' form a (C.sub.3 -C.sub.6)cycloalkyl or cyclofluoroalkyl;A is a single bond or a double bond;B.sub.1 is a single bond, an E-double bond, a Z-double bond or a triple bond; andB.sub.2 is a single bond, an E-double bond, a Z-double bond or a triple bond; or a prodrug thereof.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: December 28, 1999
    Assignees: Hoffmann-La Roche Inc., Syntex (U.S.A.)
    Inventors: Percy Sarwood Manchand, Milan Radoje Uskokovic