Abstract: The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.

Abstract: A system of control of interconnected signal emitters comprises controller modules, microcontrollers, electronic drivers and signal emitters. The connection input of each electronic driver is connected to the output of another electronic driver or to the output of a microcontroller, and the single output of each electronic driver is connected to the single connection input of another electronic driver or to the output of a microcontroller; each electronic driver being part of a driver chain between controller modules. Described developments comprise the use of Light-Emitting Diodes (LEDs), LED strips, sensors (e.g. ambient light, distance, motion, proximity, imaging, audio, temperature, pressure, etc), wired and/or wireless communication interfaces, power supply configurations and different topological arrangements (e.g. 2D, 3D, unidirectional or bidirectional arrangements, root or bridge vertices, interactive mesh, k-cyclic graphs, etc). Associated method steps (e.g.

Abstract: The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.

Abstract: The present invention relates to an optically variable security element for securing valuable articles, having a substrate having opposing first and second main surfaces and, arranged on the first main surface, an optically variable pattern that comprises an embossing pattern and a coating. The coating comprises at least one imprinted line grid and a background layer that contrasts with the line grid. The embossing pattern comprises a two-dimensional grid of elevated and/or depressed embossing elements. Both are combined in such a way that substantially on every embossing element lies at least one line segment of a line in the line grid, and at least one of the parameters position of the line segment on the embossing element, orientation of the line segment on the embossing element and form of the line segment varies location dependently across the dimension of the optically variable pattern.

Abstract: In the manufacture of carbon-carbon composite brake discs, migration of anti-oxidant substances into the friction surfaces is prevented by limiting or eliminating surface porosity in the carbon-carbon composite brake materials. The method includes infusing a suitable resin into pores in surface layers of the carbon-carbon composite disc and then charring the resin-infused disc to convert the resin in the pores to pyrolytic carbon. The resin may be infused into the carbon disc by submerging the disc in a molten resin. Prior to submerging the disc in the molten resin, the disc may subjected to a vacuum to remove air from the pores. While the disc is submerged in the molten resin, the pressure in the pressurizable vessel may increased to force the molten resin into the open porosity of the disc.

Abstract: A security element includes an optically variable structure having a multiplicity of first embossed structures each including at least two flanks which converge at at least one certain angle. In at least one first partial region of the optically variable structure, at least one flank of the first embossed structures respectively has at least one additional embossed structure which is mounted on the flank of the first embossed structures or inserted into the flank of the first embossed structures. The geometry of the at least one additional embossed structure is executed to be at least near-inverse to the geometry of that flank of the first embossed structure on which the at least one additional embossed structure is mounted or inserted.

Abstract: A precompiled form of information derived from CIL metadata is created in a compact type layout (CTL) format. Information in CTL format for each data type in a program can be represented as a contiguous byte stream. Information that is irrelevant to decisions concerning layout of a data type in memory can be suppressed. Information that is irrelevant to creation of virtual machine data structures can be suppressed. The information in CTL format may reference types, methods, and fields by CIL metadata token. Virtual override information such as, for example, a logical virtual table layout, can be pre-computed. Interface implementation information can be pre-computed. A decoder can generate data structures used in generation of an executable from the CTL formatted data.

Abstract: A precompiled form of information derived from CIL metadata is created in a compact type layout (CTL) format. Information in CTL format for each data type in a program can be represented as a contiguous byte stream. Information that is irrelevant to decisions concerning layout of a data type in memory can be suppressed. information that is irrelevant to creation of virtual machine data structures can be suppressed. The information in CTL format may reference types, methods, and fields by CIL metadata token. Virtual override information such as, for example, a logical virtual table layout, can be pre-computed. Interface implementation information can be pre-computed. A decoder can generate data structures used in generation of an executable from the CTL formatted data.

Abstract: The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.

Abstract: The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.

Abstract: In one aspect, thermal energy storage systems are described herein. In some embodiments, a thermal energy storage system comprises a thermal energy storage system comprising a container and a heat exchange apparatus disposed within the container. The heat exchange apparatus comprises a tank, a manifold at least partially disposed within the tank, and a phase change material disposed within the tank and in thermal contact with the manifold.

Abstract: A mixing and kneading machine (1) for continual compounding comprises a screw shaft (3) rotating in a casing (2) and simultaneously moving axially translationally. To sustainably enhance the efficiency of the machine as regards its material thruput per unit of time the screw shaft (3) comprises at least four groups of radial screw vanes (4a, 4b, 4c, 4d) evenly distributed circumferentially, each group consisting of a plurality of screw vanes in axial sequence. The outer diameter (Da) of the screw shaft ranges from 400 to 800 millimeters. The rotary speed of the screw shaft (3) ranges from 30 to 80 rpm. A mixing and kneading machine (1) engineered as such is particularly suitable for compounding an anodic mass in the production of electrodes—anodes—for the aluminum industry.

Abstract: In the manufacture of carbon-carbon composite brake discs, migration of anti-oxidant substances into the friction surfaces is prevented by limiting or eliminating surface porosity in the carbon-carbon composite brake materials. The method includes infusing a suitable resin into pores in surface layers of the carbon-carbon composite disc and then charring the resin-infused disc to convert the resin in the pores to pyrolytic carbon. The resin may be infused into the carbon disc by submerging the disc in a molten resin. Prior to submerging the disc in the molten resin, the disc may subjected to a vacuum to remove air from the pores. While the disc is submerged in the molten resin, the pressure in the pressurizable vessel may increased to force the molten resin into the open porosity of the disc.

Abstract: Glasses are provided that are highly transparent and have very good resistance to solarisation. The resistance to solarisation is favoured to a special extent by the production method. The concentrations of reduced polyvalent ion species are reduced by targeted use of bubbling with an oxidising gas. Methods for producing glasses and to the uses thereof, particularly as core glasses in optical waveguides, are also provided.

Abstract: The invention relates to a data carrier, especially a value document or security paper, having a substrate (20) and, applied on the substrate, a coating (12) into which, through the action of laser radiation, markings (14) are introduced in the form of patterns, letters, numbers or images. According to the present invention, it is provided that the coating (12) includes a laser-radiation-absorbing layer (22) and a printing layer (24) that is disposed over the absorbing layer and that is at least partially transmissive to the laser radiation, and that the printed substrate is pressed (26) during or after the imprinting of the at least partially transmissive layer (24).

Abstract: A security element includes an optically variable structure having a multiplicity of first embossed structures each including at least two flanks which converge at at least one certain angle. In at least one first partial region of the optically variable structure, at least one flank of the first embossed structures respectively has at least one additional embossed structure which is mounted on the flank of the first embossed structures or inserted into the flank of the first embossed structures. The geometry of the at least one additional embossed structure is executed to be at least near-inverse to the geometry of that flank of the first embossed structure on which the at least one additional embossed structure is mounted or inserted.

Abstract: In the manufacture of carbon-carbon composite brake discs, migration of anti-oxidant substances into the friction surfaces is prevented by limiting or eliminating surface porosity in the carbon-carbon composite brake materials. The method includes infusing a suitable resin into pores in surface layers of the carbon-carbon composite disc and then charring the resin-infused disc to convert the resin in the pores to pyrolytic carbon. The resin may be infused into the carbon disc by submerging the disc in a molten resin. Prior to submerging the disc in the molten resin, the disc may subjected to a vacuum to remove air from the pores. While the disc is submerged in the molten resin, the pressure in the pressurizable vessel may increased to force the molten resin into the open porosity of the disc.

Abstract: A precompiled form of information derived from CIL metadata is created in a compact type layout (CTL) format. Information in CTL format for each data type in a program can be represented as a contiguous byte stream. Information that is irrelevant to decisions concerning layout of a data type in memory can be suppressed. Information that is irrelevant to creation of virtual machine data structures can be suppressed. The information in CTL format may reference types, methods, and fields by CIL metadata token. Virtual override information such as, for example, a logical virtual table layout, can be pre-computed. Interface implementation information can be pre-computed. A decoder can generate data structures used in generation of an executable from the CTL formatted data.

Abstract: The invention relates to a value document, such as bank note, passport or the like, which has a security paper and a marking produced with the help of a laser, the security paper having at least one partial area with a coating, and the marking extending over the border area between coating and security paper. Further, the invention relates to a security paper and methods for producing an inventive value document and security paper.

Abstract: The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.