Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present invention relates to boron containing compounds of Formula (IA): that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Abstract: According to various aspects of the present disclosure, an apparatus is provided. In an aspect, the apparatus includes an optical transceiver having a first port, a second port and an optical switch coupled to the first port and the second port. The optical switch is switchable between a unidirectional port operation mode and a bidirectional port operation mode. When the optical switch is in the unidirectional port operation mode, the first port is configured to send a first optical signal, and the second port configured to receive a second optical signal. When the optical switch is in the bidirectional port operation mode, the first port configured to send the first optical signal and receive the second optical signal, and the second port configured to receive a third optical signal and not send the first signal.

Abstract: An apparatus includes a first reconfigurable optical add/drop multiplexer (ROADM) to receive a first optical signal and a second ROADM to receive a second optical signal. The apparatus also includes a reconfigurable optical switch that includes a first switch, switchable between a first state and a second state, to transmit the first optical signal at the first state and block the first optical signal at the second state. The reconfigurable optical switch also includes a second switch, switchable between the first state and the second state, to transmit the second optical signal at the first state and block the second optical signal at the second state. The reconfigurable optical switch also includes an output port to transmit an output signal that is a sum of possible optical signals transmitted through the first switch and the second switch.

Abstract: A system includes a network element having a housing that is configured for front-to-rear airflow; and a cooling apparatus located adjacent to the network element and having a housing that forms a cavity that is closed by the housing of the network element, wherein the cooling apparatus includes one or more fan units that are accessible via front access and wherein the one or more fan units are configured to draw the front-to-rear airflow from the network element into the cavity. This enables a front-to-back airflow design with rear fan access to be converted into a front-to-back airflow design with front fan access.

Abstract: Methods and apparatus for unitizing groups of individual packages into pallet loads, stabilizing the loads and facilitating general movement of the pallets, including the loading and unloading of pallets into and out of transport vehicles, includes wrapping the loads with stretchable crepe paper, rather than conventional plastic wrap material. Crepe paper can be produced and recycled with less environmental impact than plastic wrap. These methods involve a new use for crepe paper, and a new use for conventional plastic-wrapping equipment.

Abstract: A system includes a network element having a housing that is configured for front-to-rear airflow; and a cooling apparatus located adjacent to the network element and having a housing that forms a cavity that is closed by the housing of the network element, wherein the cooling apparatus includes one or more fan units that are accessible via front access and wherein the one or more fan units are configured to draw the front-to-rear airflow from the network element into the cavity. This enables a front-to-back airflow design with rear fan access to be converted into a front-to-back airflow design with front fan access.

Abstract: A method includes configuring one or more permissions for a first page of memory including a first section of a plurality of sections of an executable program code to enable execution of the first section. The method also includes configuring one or more permissions for a second page of the memory including a second section of the executable program code to disable execution of the second section. The method also includes identifying one or more annotations in the executable program code, wherein the one or more annotations indicate one or more allowed transitions and one or more disallowed transitions between the plurality of sections. The method also includes changing, in view of the one or more annotations, the one or more permissions of the second page to enable execution of the second section of the executable program code.

Abstract: Methods and apparatus for unitizing groups of individual packages into pallet loads, stabilizing the loads and facilitating general movement of the pallets, including the loading and unloading of pallets into and out of transport vehicles, includes wrapping the loads with stretchable crepe paper, rather than conventional plastic wrap material. Crepe paper can be produced and recycled with less environmental impact than plastic wrap. These methods involve a new use for crepe paper, and a new use for conventional plastic-wrapping equipment.

Abstract: An apparatus includes a first input port, a first switch, and a second switch. The first switch and the second input port are in optical communication with the first input port. The apparatus also includes a second input port, a third switch, and a fourth switch. The third switch and the fourth switch are in optical communication with the second input port. Each switch is switchable between a first state to pass optical signals and a second state to block optical signals. The apparatus also includes a first combiner in optical communication with the first input port via the first switch and the second input port via the third switch. The apparatus also includes a second combiner in optical communication with the first input port via the second switch and the second input port via the fourth switch.

Abstract: A method includes loading each section of an executable program code into a respective page of memory, configuring permissions for a first page including a first section of the executable program code to enable execution of the first section loaded into the first page. The first section associated with a first label. The method also includes configuring permissions for a second page of the memory including a second section of the executable program code to disable execution of the second section loaded into the second page. The second section associated with a second label. Responsive to a determination that a transition from the first section to the second section is allowed during execution of the executable program code, the method also includes changing the permissions of the second page to enable execution of the second section of the executable program code.

Abstract: 3D cell cultures and devices for 3D cell culture, and methods of use thereof are provided. In some embodiments, the 3D cell culture comprise pancreatic ? cells and can be generated in multi-well plates, allowing for high throughput assays on the cell culture.

Abstract: A control unit (32) is provided and communicatively coupled with the transmitter circuit (30) and the receiver circuit (31). The first scale elements (28) have a first flux modulating property and a second flux modulating property, that are different to each other, wherein each flux modulating property is adapted to modulate a magnetic field created by the first or second transmitter coil (34, 35) dependent from the position of a movement of the sensor unit (25) in measuring direction (x). In so doing independent position information can be created by only one track (26) of scale elements (28) by modulating the first magnetic field (B1) from the first transmitter coil (34) and the second magnetic field (B2) from the second transmitter coil (35).

Abstract: A plurality of system control devices respectively include network interfaces for communicating with each other via a network. One of the plurality of system control devices functions as a master system control device, and the remaining system control devices function as slave system control devices. The master system control device transmits a control command to the slave system control devices by means of the network interface. The slave system control devices receive the control command by means of the network interfaces and supply an operation command to abatement devices in accordance with the control command. When unable to communicate with the master system control device, the slave system control devices either function as master system control devices or enter stand-alone operation mode.

Abstract: A method of identifying subjects having prostate cancer is provided. The method includes obtaining a sample from a subject, isolating DNA from the sample, determining the methylation status of the DNA, and comparing the methylation status of the DNA to one or more methylated probes selected from the following: cg00697992, cg01272707, cg01819167, cg01906055, cg02160684, cg02560085, cg03195164, cg03456213, cg04634417, cg06024295, cg11748187, cg13300630, cg13944838, cg14399930, cg15132013, cg16469740, cg17004353, cg17032646, cg18315943, cg19550524, cg20399616, cg24517686, cg25961816, cg26447413 and cg27198013. The comparison indicates whether the sample is normal, a non-aggressive prostate cancer, or an aggressive prostate cancer.

Abstract: An apparatus includes a tail-end optical switch configured to be coupled to a broadcast star network that couples the tail-end optical switch to a head-end optical switch by a primary bidirectional optical path and a second bidirectional optical path. The tail-end optical switch having a first optical switch and a second optical switch configured to provide active switching.

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Systems and methods for dewatering slurries having relatively high solids content such as earthen slurries are disclosed. In some embodiments, one or more transducer devices configured for acoustic spectroscopy and/or electroacoustic spectroscopy are used to determine a parameter related to the particle size distribution (e.g., specific surfaced area) and/or zeta potential of the slurry.

Abstract: Dampers (100), assemblies, and methods are provided for lead-lag damping for an articulated rotor and includes a lead-lag damper (100) having a first end connector (102) configured to be coupled to a rotor hub (H), a second end connector (104) configured to be coupled to one of a plurality of rotor blades (B), and a body portion (110) coupled to the first end connector (102) and to the second end connector (104). The body portion (110) includes one or more elastomeric material layers (120) arranged in a lengthwise direction between the first end connector (102) and the second end connector (104), with each of the elastomeric material layers (120) having a substantially chevron-shaped profile in a crosswise direction.