Abstract: The present invention provides for novel immunogenic variants of VEGF (vascular endothelial growth factor) which are useful in active specific immunotherapy against diseases that are characterized by overexpression of VEGF. The invention also relates to methods of treating such diseases (for instance cancer) as well as to various tools in molecular biology that assist in the provision of the immunogenic variants.

Abstract: A method for in vivo down-regulation of amyloid protein in an animal, including a human being, the method comprising effecting presentation to the animal's immune system of an immunogenically effective amount of at least one amyloidogenic polypeptide or subsequence thereof which has been formulated so that immunization of the animal with the amyloidgenic polypeptide or subsequence thereof induces production of antibodies against the amyloidogenic polypeptide, and/or at least one analogue of the amyloidogenic polypeptide wherein is introduced at least one modification in the amino acid sequence of the amyloidogenic polypeptide which has as a result the immunization of the animal with the analogue induces production of antibodies against the amyloidogenic polypeptide.

Abstract: A drive system for a refrigeration compressor such as is used in a natural gas liquefaction plant, allowing the desired compressor speed and maximum turbine efficiency to be maintained throughout varying ambient temperature conditions. A gas turbine is used with an electric starter motor with drive-through capability located on a common drive shaft between the turbine and the compressor. A variable frequency drive (VFD) is connected between the electrical power grid and the electric motor for smooth startups, but also to allow excess turbine mechanical power to be converted to electrical power by the motor operating as a generator, and delivered to the grid at the grid frequency. Pulse width modulation technology may be used to reduce harmonic distortion in the VFD's output. The starter motor also functions as a helper motor when the turbine output is insufficient to drive the compressor at the rotational speed needed to meet throughput requirements.

Abstract: A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen presenting cells are induced to present at least one CTL epitope of the weak antigen and at the same time presenting at least one foreign T-helper lymphocyte epitope. In a preferred embodiment, the antigen is a cancer specific antigen, e.g. PSM, Her2, or FGF8b. The method can be exercised by using traditional polypeptide vaccination, but also by using live attenuated vaccines or nucleic acid vaccination. The invention furthermore provides immunogenic analogues of PSM, Her2 and FGF8b, as well as nucleic acid molecules encoding these analogues. Also vectors and transformed cells are disclosed. The invention also provides for a method for identification of immunogenic analogues of weak or non-immunogenic antigens.

Abstract: The invention relates to apparatuses for treating surfaces of teeth by using a mixture of pressurised gas, preferably pressurised air, and abrasive particles such as particles of aluminium oxide. A first apparatus comprises a chamber having at least a primary inlet and preferably an additional inlet and also having an outlet. The primary inlet establishes a vortex within the chamber and the additional inlet fluidises the abrasive particles lying in the bottom of the chamber. A second apparatus comprises a handpiece with a nozzle having an outlet provided with notches or holes. The notches or holes constitute additional discharge openings apart from an orifice in the nozzle. Both of the apparatuses ensure that the pressure needed for the treatment and the amount of abrasive particles for the treatment is minimised as much as possible.

Abstract: The present invention relates to novel medical applications of down-regulation of tumour necrosis factor ? (TNF-?) activity, especially novel applications of active immunization against TNF-a in order to reduce or alleviate pain. In particular, the present invention discloses novel methods for treating or ameliorating neuropathic pain.

Abstract: Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (A?). Immunization is preferably effected by administration of analogues of autologous APP or A?, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A? which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or A? and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

Abstract: This invention relates to an electric multiple motor/generator with axial magnetic flux. Thus a generator/motor or electrical machine in which a magnetic flux path through one or more pole legs or pole cores surrounded by current windings or coils is provided. This allows a high density of the magnetic flux to be passed through the pole legs or cores, which results in a low consumption of material for the pole legs or pole cores compared with prior art machines, where for example a large stator diameter may be needed in order to conduct a high magnetic flux. Additionally the generator/motor or electrical machine is very efficient both at a low and a high number of revolutions. According to another aspect of the invention a multiple phase output without enlarging the diameter of the generator is provided.

Abstract: The invention concerns a generator for a windmill. The generator is of the kind being directly coupled to the main shaft of the wind rotor of the windmill. The generator is a stator consisting of a number of stator modules that are individual and which may be installed, repaired and dismantled individually and independently of each other. This implies that it is very easy and thereby cheaper to mount the mill, especially at sea, as the stator for the generator can be transported in smaller units, which also makes it easier to assemble the stator in the tower top section. By sequent repairs and other maintenance of the generator it is not necessary either to use large cranes, but it is sufficient to use smaller hoisting devices that may be handled by one or two persons.

Abstract: The invention relates to apparatuses for treating surfaces of teeth by using a mixture of pressurised gas, preferably pressurised air, and abrasive particles such as particles of aluminium oxide. A first apparatus comprises a chamber having at least a primary inlet and preferably an additional inlet and also having an outlet. The primary inlet establishes a vortex within the chamber and the additional inlet fluidises the abrasive particles lying in the bottom of the chamber. A second apparatus comprises a handpiece with a nozzle having an outlet provided with notches or holes. The notches or holes constitute additional discharge openings apart from an orifice in the nozzle. Both of the apparatuses ensure that the pressure needed for the treatment and the amount of abrasive particles for the treatment is minimised as much as possible.

Abstract: A device for supplying filtering aids and/or process materials during filtration is used in many applications, in particular, also in the beverage industry. Such a device comprises at least one storage container (5, 6, 7), in which the filtering aids and/or process materials are contained. Moreover, means (25, 26, 27) for metered removal from at least one storage container are provided to which is connected a suspension container (28) or mixing container. Means (44) for metered removal from the container (28) are provided. By means of sensors (48, 49) the current filtration data are measured and supplied to an electronic control unit so that, taking into consideration the current values, a metered removal of the filtering aids and/or process materials is realized.

Abstract: A flexible sheet can be stored or patterned while in a flat configuration, and subsequently readily adapted to overlay a curved surface, for example a hemisphere of a sphere. Radial incisions made to the sheet provide a hub and a plurality of substantially triangular gores that adapt the sheet to conform substantially to the curved surface. A patternable transparent cover, adapted to be removably and/or pivotally secured to the hemisphere, closely overlays the sheet to form a covering assembly. Covering assemblies may be placed over one or both hemispheres of a sphere and fixedly or removably joined together.

Abstract: In a method for fixing an optical fibre in an optical fibre connector element the fibre is fixed therein by means of centering elements (22) and a curable material (28), for example an adhesive. The centering elements and the curable material are positioned between the envelope of an end portion of the optical fibre (6) and a surface portion (26) of the connector element surrounding said envelope. After the fixing of the fibre end portion in the connector element the end portion of the connector element including the centering elements (22) and the fibre end portion (6) are machined, for example ground, up to a plane (30) which is positioned inside the points of contact between the centering elements (22) and the fibre end portion (6) and between the centering elements (22) and the surface portion (26) of the connector element surrounding the fibre end portion.