Patents by Inventor Peter Stanley Borromeo

Peter Stanley Borromeo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ring modified cyclic peptide analogs
    Patent number: 6939946
    Abstract: A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: September 6, 2005
    Assignee: Eli Lilly and Company
    Inventors: Peter Stanley Borromeo, Jeffrey Daniel Cohen, George Stuart Gregory, Stacy Kay Henle, Stephen Andrew Hitchcock, Louis Nickolaus Jungheim, Daniel Ray Mayhugh, Timothy Alan Shepherd, William Wilson Turner, Jr.
  • Ring modified cyclic peptide analogs
    Patent number: 6653281
    Abstract: A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal omithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: November 25, 2003
    Assignee: Eli Lilly and Company
    Inventors: Peter Stanley Borromeo, Jeffrey Daniel Cohen, George Stuart Gregory, Stacy Kay Henle, Stephen Andrew Hitchcock, Louis Nickolaus Jungheim, Daniel Ray Mayhugh, Timothy Alan Shepherd, William Wilson Turner, Jr.