Patents by Inventor Peter Van Hoogevest
Peter Van Hoogevest has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230165795Abstract: A composition comprising a liposome comprising a first phospholipid comprising a C14-C19:0 fatty acid and a C3-C15:0 fatty acid with a c-terminal carboxyl or a carboxaldehyde group; a second phospholipid comprising a C14-C19:0 fatty acid and a C14-C19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.Type: ApplicationFiled: March 20, 2019Publication date: June 1, 2023Inventors: Jai Prakash, Peter Van Hoogevest, Gerrit Storm
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Publication number: 20230157309Abstract: The present invention relates to sunflower phospholipid compositions containing phosphatidylcholine and containing less than 0.1% by weight, in particular less than 0.08% by weight or less than 0.05% by weight and especially less than 0.02% by weight of chlorogenic acids, based on the total weight of the sunflower phospholipid composition, and combination thereof with at least one anionic stabilizer compound comprising at least one anionic phospholipid compound. These combinations are particularly useful as emulsifiers in aqueous oil-in-water emulsions. The present invention also relates to aqueous oil-in-water emulsions containing such combinations of a sunflower phospholipid composition with at least one anionic stabilizer compound comprising at least one anionic phospholipid compound. The invention also relates to a method for the production of such emulsions.Type: ApplicationFiled: March 11, 2021Publication date: May 25, 2023Inventors: Peter VAN HOOGEVEST, Christoph HEIDECKE
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Patent number: 10603384Abstract: The invention relates to pharmaceutical compositions, particularly for intravenous administration, containing {8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-yl}acetic acid in combination with at least one of the cyclodextrin excipients, lysine and arginine; the method for its production; and its use in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.Type: GrantFiled: February 28, 2013Date of Patent: March 31, 2020Assignee: AICURIS GMBH & CO. KGInventors: Kerstin Paulus, Wilfried Schwab, Dominique Grunder, Peter Van Hoogevest
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Publication number: 20160299113Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.Type: ApplicationFiled: November 18, 2014Publication date: October 13, 2016Inventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
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Publication number: 20150133461Abstract: The invention relates to pharmaceutical compositions, particularly for intravenous administration, containing {8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-yl}acetic acid in combination with at least one of the cyclodextrin excipients, lysine and arginine; the method for its production; and its use in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.Type: ApplicationFiled: February 28, 2013Publication date: May 14, 2015Applicant: AICURIS GMBH & CO. KGInventors: Kerstin Paulus, Wilfried Schwab, Dominique Grunder, Peter Van Hoogevest
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Patent number: 9005597Abstract: The present invention is directed to a composition for treating vaginal dryness and lack of lubrication comprising: a poloxamer component; a phospholipid component; an optional oil component; and a non-aqueous carrier; wherein the composition is substantially anhydrous. In another aspect, the present invention is directed to a method of treating vaginal dryness comprising the step of administering to a patient suffering from vaginal dryness the above composition.Type: GrantFiled: October 29, 2009Date of Patent: April 14, 2015Assignee: Medlite A/SInventors: Ketil Andre Hansen, Tore Fagerland, John Afseth, Matthew Leigh, Elsa Kung, Peter van Hoogevest
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Publication number: 20150037397Abstract: The present invention relates to pharmaceutical compositions comprising a compound of formula (I) and a cyclodextrin or a liposome, to the process of preparing said compositions and their use for antitumor, antiviral, antiparasitic and antifungal treatment.Type: ApplicationFiled: December 22, 2011Publication date: February 5, 2015Applicant: TRASLATIONAL CANCER DRUGS PHARMA, S.L.Inventors: Beatriz Palacios Izquierdo, Peter Van HoogeVest, Mathew L.S. Leigh
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Patent number: 8889189Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.Type: GrantFiled: October 16, 2012Date of Patent: November 18, 2014Assignee: Phares Pharmaceutical Research, N.V.Inventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
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Patent number: 8753652Abstract: The present invention relates to a pharmaceutical composition to be parenterally administered, including submicronic ester particles of docosahexaenoic acid, dispersed in an aqueous phase using a mixture of at least two surfactants selected from among a) at least one polyoxyethylene fatty acid ester and b) at least one phospholipid derivative. The present invention also relates to the method for preparing said pharmaceutical composition.Type: GrantFiled: August 11, 2010Date of Patent: June 17, 2014Assignee: Pierre Fabre MedicamentInventors: Elie Leverd, Peter Van Hoogevest, Elsa Kung, Mathew Leigh
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Patent number: 8632832Abstract: The present disclosure describes a method for the continuous dissolution of e.g. crystalline astaxanthin or canthaxanthin suspension in oil, by applying heat for a predetermined period using an in-line or optionally batch wise-process, followed by cooling the heated solution with an oil phase or heat exchanger. The resulting oil solution may be used as such or added directly to feed components which are turned into feed compositions by extrusion, compaction or granulation. Alternatively the oil solution is spray coated or directly loaded to extruded or compacted pellets and granulates. The disclosure avoids using formulated carotenoids prepared by known multi-step production methods requiring solvents, solvent removal, cooling and emulsification with an aqueous phase or precipitation and recovery steps.Type: GrantFiled: November 21, 2007Date of Patent: January 21, 2014Assignee: Phares Pharmaceutical Research N.V.Inventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest
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Patent number: 8287907Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.Type: GrantFiled: November 10, 2006Date of Patent: October 16, 2012Assignee: Phares Pharmaceutical Research, N.V.Inventors: Steve Leigh, Matthew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
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Publication number: 20120141563Abstract: The present invention relates to a pharmaceutical composition to be parenterally administered, including submicronic ester particles of docosahexaenoic acid, dispersed in an aqueous phase using a mixture of at least two surfactants selected from among a) at least one polyoxyethylene fatty acid ester and b) at least one phospholipid derivative. The present invention also relates to the method for preparing said pharmaceutical composition.Type: ApplicationFiled: August 11, 2010Publication date: June 7, 2012Applicant: PIERRE FABRE MEDICAMENTInventors: Elie Leverd, Peter Van Hoogevest, Elsa Kung, Mathew Leigh
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Publication number: 20110262381Abstract: The present invention is directed to a composition for treating vaginal dryness and lack of lubrication comprising: a poloxamer component; a phospholipid component; an optional oil component; and a non-aqueous carrier; wherein the composition is substantially anhydrous. In another aspect, the present invention is directed to a method of treating vaginal dryness comprising the step of administering to a patient suffering from vaginal dryness the above composition.Type: ApplicationFiled: October 29, 2009Publication date: October 27, 2011Inventors: Ketil Andre Hansen, Tore Fagerland, John Afseth, Mathew Leigh, Elsa Kung, Peter Van Hoogevest
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Publication number: 20110244028Abstract: The invention describes a method of preparing lipid compositions by associating pH sensitive compounds which maybe weak acids, bases or amphoteric compounds with at least one ionisable or pH sensitive group and low water solubility into preformed and standardised lipid particles by pH manipulation. Drug association is carried out in situ by changing the pH of the aqueous medium to pH 6-8 wherein the compound spontaneously partitions into the lipid particles. Drug association may also be carried out by exploiting pH changes in the GI tract. The lipophilic compound is solubilised by the lipid particles and may be used as such for in-vitro and pharmacokinetic assessments or processed for oral, parenteral or topical therapy.Type: ApplicationFiled: September 28, 2009Publication date: October 6, 2011Inventors: Steve Leigh, Mathew Leuis Steven Leigh, Peter Van Hoogevest
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Publication number: 20110124691Abstract: Pharmaceutical formulations comprising an epothilone in the form of an infusion concentrate or a lyophilised composition, and methods of administration of an epothilone in suitable form for parenteral administration.Type: ApplicationFiled: February 4, 2011Publication date: May 26, 2011Inventor: Peter van Hoogevest
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Patent number: 7563935Abstract: Mixtures of specific crystal forms of astaxanthin and the individual crystal forms designated crystal Form I and II and disclosed together with methods for preparing said crystal Forms. Methods for preparing nutritional dosage forms including the disclosed astaxanthin crystal forms for the life science industry are also disclosed.Type: GrantFiled: February 15, 2008Date of Patent: July 21, 2009Assignee: Phares Pharmaceutical Research N.V. et al.Inventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest
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Publication number: 20090145248Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.Type: ApplicationFiled: November 10, 2006Publication date: June 11, 2009Applicant: PHARES PHARMACEUTICAL RESEARCH N.V.Inventors: Steve Leigh, Matthew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
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Publication number: 20080311267Abstract: The present disclosure describes a method for the continuous dissolution of e.g. crystalline astaxanthin or canthaxanthin suspension in oil, by applying heat for a predetermined period using an in-line or optionally batch wise-process, followed by cooling the heated solution with an oil phase or heat exchanger. The resulting oil solution may be used as such or added directly to feed components which are turned into feed compositions by extrusion, compaction or granulation. Alternatively the oil solution is spray coated or directly loaded to extruded or compacted pellets and granulates. The disclosure avoids using formulated carotenoids prepared by known multi-step production methods requiring solvents, solvent removal, cooling and emulsification with an aqueous phase or precipitation and recovery steps.Type: ApplicationFiled: November 21, 2007Publication date: December 18, 2008Applicant: PHARES PHARMACEUTICAL RESEARCHInventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest
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Publication number: 20080234521Abstract: Mixtures of specific crystal forms of astaxanthin and the individual crystal forms designated crystal Form I and II and disclosed together with methods for preparing said crystal Forms. Methods for preparing nutritional dosage forms including the disclosed astaxanthin crystal forms for the life science industry are also disclosed.Type: ApplicationFiled: February 15, 2008Publication date: September 25, 2008Applicant: PHARES PHARMACEUTICAL RESEARCH N. V.Inventors: Steve LEIGH, Mathew Louis Steven Leigh, Peter Van Hoogevest
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Publication number: 20080221065Abstract: Pharmaceutical formulations comprising an epothilone in the form of an infusion concentrate or a lyophilised composition, and methods of administration of an epothilone in suitable form for parenteral administration.Type: ApplicationFiled: May 20, 2008Publication date: September 11, 2008Applicant: NOVARTIS AGInventor: Peter van Hoogevest