Patents by Inventor Peter W. Sprague

Peter W. Sprague has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Halogenated substituted mercaptoacylamino acids
    Patent number: 4241076
    Abstract: New halogen substituted mercaptoacylamino acids which have the general formula ##STR1## and basic salts thereof are useful as hypotensive agents.
    Type: Grant
    Filed: May 9, 1979
    Date of Patent: December 23, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Peter W. Sprague
  • 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
    Patent number: 4228180
    Abstract: New 7-oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs which have the general formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; n is 0 to 4, m is 0 to 4 and x is 0 to 8, are useful as cardiovascular agents.
    Type: Grant
    Filed: November 1, 1979
    Date of Patent: October 14, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter W. Sprague
  • 7-Oxabicycloheptane compounds
    Patent number: 4187236
    Abstract: New 7-oxabicycloheptane compounds which have the general formula ##STR1## wherein each R is independently hydrogen or hydroxy, at least one R being hydroxy; R.sup.1 is hydrogen or lower alkyl; R.sup.3 is ##STR2## are useful as cardiovascular agents.
    Type: Grant
    Filed: November 6, 1978
    Date of Patent: February 5, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter W. Sprague
  • Halogen substituted mercaptoacylamino acids
    Patent number: 4154935
    Abstract: New halogen substituted mercaptoacylamino acids which have the general formula ##STR1## ARE USEFUL AS HYPOTENSIVE AGENTS.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Peter W. Sprague
  • 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
    Patent number: 4143054
    Abstract: New 7-oxabicycloheptane- and 7-oxabicycloheptene compounds which have the general formula ##STR1## and intermediates therefor which have the general formulas ##STR2## are useful as cardiovascular agents.
    Type: Grant
    Filed: November 4, 1977
    Date of Patent: March 6, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter W. Sprague
  • Amidines
    Patent number: 4108894
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is aryl and both R.sub.2 groups are hydrogen or alkyl, have useful antiinflammatory activity.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: August 22, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter W. Sprague
  • 1,3-Benzodithiolanes
    Patent number: 4107175
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, nitro, amino, or hydroxy; R.sub.2 is carboxyl or alkoxycarbonyl; and n is 0, 1, 2, 3, 4 or 5; have antiinflammatory activity.
    Type: Grant
    Filed: December 17, 1976
    Date of Patent: August 15, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, James E. Heikes
  • 1,3-Benzodithiolanes
    Patent number: 4104467
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, nitro, amino, or hydroxy; and R.sub.2 is an amino group, a 5- or 6-membered heterocyclic group, a 3-indolyl group, carboxyl, or alkoxycarbonyl; and n is 0, 1, 2, 3, 4 or 5; have antiinflammatory activity.
    Type: Grant
    Filed: July 16, 1976
    Date of Patent: August 1, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, James E. Heikes
  • Amidines
    Patent number: 4086244
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is aryl, have useful antiinflammatory activity.
    Type: Grant
    Filed: December 10, 1976
    Date of Patent: April 25, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter W. Sprague
  • 3,6-Dicarboximidamidecarbazoles
    Patent number: 4061655
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is aryl and R.sub.2 is alkyl or arylalkyl, have useful antiinflammatory activity.
    Type: Grant
    Filed: December 30, 1976
    Date of Patent: December 6, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter W. Sprague
  • 4,5-Secoandrostanes
    Patent number: 3984474
    Abstract: 4,5-Secoandrostanes having the formula ##SPC1##Have useful anti-inflammatory activity wherein R.sub.1 is hydrogen and R.sub.2 is hydroxyl, R.sub.1 is hydroxyl and R.sub.2 is hydrogen, R.sub.1 and R.sub.2 are each hydrogen, or together R.sub.1 and R.sub.2 are =0; R.sub.3 is hydrogen and R.sub.4 is hydroxyl, R.sub.3 is hydroxyl and R.sub.4 is hydrogen, R.sub.3 and R.sub.4 are each hydrogen, or together R.sub.3 and R.sub.4 are =0; R.sub.5 is hydrogen or hydroxyl; and R.sub.6 is hydrogen or halogen.
    Type: Grant
    Filed: May 30, 1975
    Date of Patent: October 5, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, Christopher M. Cimarusti