Abstract: An instrumented pig comprises a foam body having an outer surface and an inner cavity in which, in use, is located a sealed unit housing at least a part of a parameter measurement apparatus configured to measure at least one parameter from which the extent of deflection of the outer surface of the foam body may be derived, the sealed unit including at least one sensor configured to generate an output signal representative of the at least one measured parameter.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11?-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11?-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

Abstract: A belt planetary transmission comprising a sun gear (1) having sun gear teeth (11), a ring gear (3) having ring gear teeth (31), a first toothed belt (4) trained between a first idler (50 and a second idler (51), the first idler and the second idler rotationally connected to a carrier (2), the first toothed belt (4) in simultaneous meshing contact with the ring gear teeth and the sun gear teeth, a second toothed belt (40) trained between a third idler (401) and a fourth idler (402), the third idler and the fourth idler rotationally connected to the carrier, the second toothed belt in simultaneous meshing contact with the ring gear teeth and the sun gear teeth, each of the first idler, second idler, third idler and fourth idler having a center of rotation disposed at a radius (R) from a center of rotation (A-A), and the first toothed belt and the second toothed belt are each in continuous meshing contact with the ring gear teeth and the sun gear teeth through an angle (?) of approximately 90°.

Abstract: A flexible member test apparatus comprising a driver member having a first diameter and a second diameter, the first diameter is not equal to the second diameter, a first driven member coupled by a first flexible member to the driver member through contact of the first flexible member with a first diameter surface, a second driven member coupled by a second flexible member to the driver member through contact of the second flexible member with a second diameter surface, the first driven member rotationally coupled to a magnetic particle clutch, and the second driven member rotationally coupled to the magnetic particle clutch.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11?-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11?-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

Abstract: A system and method for media asset management. An original media asset for a media project is identified and a plurality of versions of the original media asset is also identified. The plurality of versions of the media asset include at least one modified version of the original media asset. Typically each of the plurality of versions of the original media asset includes a plurality of components, and the modified versions of the original media asset include at least one modified component. The component being modified is based on a corresponding component of the original media asset. Metadata for each of the plurality of components is generated that indicates whether each component is a modified component, and the metadata of the modified component indicates a type of modification made to the modified component.

Abstract: A system and method for organizing media assets of a media project. The method includes storing a plurality of versions of media assets of the media project, including an original version of the media asset and at least one modified version of the media asset. Each of the plurality of versions of the media assets include a plurality of components, and the modified versions of the media assets include at least one modified component. Metadata for each of the plurality of components is generated. The metadata indicates whether each of the plurality of component is a modified component, and the metadata of the modified component indicates a type of modification made to the modified component.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-isothiazole compounds that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11?-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11?-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

Abstract: An isolator comprising a hub, a pulley journalled to the hub, the pulley having a stop, the hub having a resilient member for engaging the stop, a torsion spring connected between the pulley and the hub, an inertial member attached to the hub by a flexible member, the inertial member disposed within a pulley receiving portion that is disposed radially inward of a pulley belt engaging surface, and the resilient member having a convex surface for engaging the stop such that a spring rate of the resilient member is non-linear upon a compression against the stop.

Abstract: An isolator comprising a shaft (10), a pulley (20) journalled to the shaft on a first bushing (40) and a second bushing (50), a torsion spring (30) engaged with the shaft and the pulley, the torsion spring exerting an axial contractive force to retain the pulley on the shaft, a cover member (60) fixed to the shaft, the pulley urged into engagement with the cover member by the torsion spring axial contractive force, the cover member further comprising an axially projecting member (62) disposed radially outwardly of the torsion spring, the pulley comprising a circumferential pocket (24) for cooperatively receiving the projecting member and having a stop (23) disposed within the circumferential pocket, and a rubber member (80) disposed with the stop for engaging the projecting member.

Abstract: An isolator comprising a shaft (10), a pulley (20) journalled to the shaft on a first bushing (40) and a second bushing (50), the shaft comprising a shaft stop (12) disposed on a shaft radially outer surface (14), the pulley and the shaft rotationally moveable relative to each other, the pulley comprising an inner hub (23), the inner hub having a pulley stop (24) disposed to cooperatively engage the shaft stop, a torsion spring (30) engaged with the shaft and the pulley, the torsion spring exerting a contractive force parallel to an axis of rotation (A-A) in order to retain the pulley on the shaft, a cover member (60) fixed to the shaft, the pulley urged into engagement with the cover member by the torsion spring axial contractive force, and a rubber member (80) disposed on the shaft stop for engaging the pulley stop.

Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.

Abstract: A tensioner comprising a base (7), a pivot arm (1) pivotally engaged with the base, a torsion spring (9) engaged between the base and the pivot arm, the torsion spring loadable by movement of the arm in an unwinding direction, a damping mechanism (8) frictionally engaged with an arm inner surface (11) and in a pressing engagement with the base, and further bearing upon a stop (71) on the base, and the damping mechanism urged radially outward into engagement with the inner surface of the arm as the torsion spring is loaded in the unwinding direction and by a pivotal motion of the damping mechanism about the stop (71).

Abstract: Silicon photomultiplier circuitry is provided that comprises at least one silicon photomultiplier pixel, each pixel comprising a plurality of silicon photomultiplier microcells. The silicon photomultiplier circuitry comprises control circuitry adapted to maintain a substantially constant voltage on a connection node between microcells of the pixel. The control circuitry is adapted to minimise the onset and recovery time of an output signal by maintaining a substantially constant voltage on the connection node.

Abstract: An isolator decoupler comprising a pulley, a shaft, a bushing slidingly engaged with the pulley and slidingly engaged with the shaft, the pulley journalled to the shaft by a bearing, a one-way clutch fixed to the shaft and engaged with the bushing whereby the bushing rotates in unison with the one-way clutch, a torsion spring engaged between the pulley and the one-way clutch to resiliently couple the pulley to the shaft, and the pulley non-resiliently directly coupleable to the shaft in a temporary predetermined loaded condition.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11?-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11?-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

Abstract: Laminates comprising at least two glass plys surrounding at least one interlayer having at least one bore extending through the laminate are produced by excluding the interlayer from the area surrounding the bore(s) and positioning a load bearing insert around the bore. The insert may be positioned before or after the laminating process. The invention reduces the tendency for delamination around the area of the bore when the laminate is placed under load.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11?-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11?-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

Abstract: A planetary transmission comprising an input member, an output member, a planetary gear assembly mechanically disposed between the input member and the output member, a centrifugal clutch mechanically disposed between the input member and the output member, a one-way clutch mechanically disposed between the input member and the output member, the one-way clutch for directly coupling the input member and the output member from zero rotational speed up to a first rotational speed, the centrifugal clutch for directly coupling the input member and the output member from a second rotational speed greater than zero rotational speed to a third rotational speed which is in excess of the first rotational speed, and a brake member for selectively controlling rotation of the planetary gear assembly.

Abstract: A method, computer program, and system for paging platform configuration registers in and out of a trusted platform module. In a trusted computing platform, an unlimited number of platform configuration registers can be obtained through paging. The trust platform module encrypts and decrypts platform configuration registers for storage outside the trusted platform module.