Patents by Inventor Petr ZAHRADNIK

Petr ZAHRADNIK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11104650
    Abstract: An improved process for preparing 2-chloro-4-nitroimidazole derivatives which are useful intermediates in the preparation of an anti-tuberculosis drug is provided. The process may comprise the step of chlorinating nitroimidazoles with a chlorinating agent and an activating agent to give 2-chloro-4-nitroimidazole derivatives.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: August 31, 2021
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Petr Novak, Petr Zahradnik, Jiri Tauchman, Jan Koci, Antonin Sturc
  • Patent number: 11098067
    Abstract: The present invention relates to a method of production of 4-boronophenylalanine (BPA) from 4-iodophenylalanine, in which all the functional groups of the amino acid are protected by benzyl protection method, and which uses isopropyl magnesium halogenide stabilized by a complexation base, and subsequent condensation of the resulting Grignard reagent with a boric acid ester. The final reaction step, catalytic hydrogenolysis or transfer hydrogenolysis of protecting groups on the amino acid, occurs after hydrolysis of the boronate ester groups.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: August 24, 2021
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Petr Zahradnik, Antonin Sturc, Jiri Malinak, Jan Koci
  • Publication number: 20210053925
    Abstract: An improved process for preparing 2-chloro-4-nitroimidazole derivatives which are useful intermediates in the preparation of an anti-tuberculosis drug is provided. The process may comprise the step of chlorinating nitroimidazoles with a chlorinating agent and an activating agent to give 2-chloro-4-nitroimidazole derivatives.
    Type: Application
    Filed: January 29, 2018
    Publication date: February 25, 2021
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Petr NOVAK, Petr ZAHRADNIK, Jiri TAUCHMAN, Jan KOCI, Antonin STURC
  • Publication number: 20200392163
    Abstract: The present invention relates to a method of production of 4-boronophenylalanine (BPA) from 4-iodophenylalanine, in which all the functional groups of the amino acid are protected by benzyl protection method, and which uses isopropyl magnesium halogenide stabilized by a complexation base, and subsequent condensation of the resulting Grignard reagent with a boric acid ester. The final reaction step, catalytic hydrogenolysis or transfer hydrogenolysis of protecting groups on the amino acid, occurs after hydrolysis of the boronate ester groups.
    Type: Application
    Filed: February 19, 2019
    Publication date: December 17, 2020
    Inventors: Petr ZAHRADNIK, Antonin STURC, Jiri MALINAK, Jan KOCI
  • Publication number: 20200095191
    Abstract: The present invention relates to a 5-step process for preparing iosimenol starting from ammonium 3-amino-5-(aminocarbonyl)benzoate which is first converted to 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoic acid using sodium iodine dichloride (NaI—Cl2). The present invention further relates to processes for purifying iosimenol.
    Type: Application
    Filed: April 27, 2018
    Publication date: March 26, 2020
    Inventors: Jiri MALINAK, Ivan HLAVACEK, Petr ZAHRADNIK
  • Publication number: 20190298862
    Abstract: Iohexol particles, contrast agent compositions comprising iohexol particles, methods of preparing iohexol particles, and methods of administering iohexol particles are provided herein. The iohexol particles of the present invention substantially dissolve in water within about 60 seconds when tested using Modified United States Pharmacopeia Method 641.
    Type: Application
    Filed: June 5, 2019
    Publication date: October 3, 2019
    Applicant: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Jirí PROKOP, Ivan HLAVÁCEK, Petr ZAHRADNÍK, Jirí MALINAK
  • Patent number: 10350311
    Abstract: Iohexol particles, contrast agent compositions comprising iohexol particles, methods of preparing iohexol particles, and methods of administering iohexol particles are provided herein. The iohexol particles of the present invention substantially dissolve in water within about 60 seconds when tested using Modified United States Pharmacopeia Method 641.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: July 16, 2019
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Ji{hacek over (r)}í Prokop, Ivan Hlavá{hacek over (c)}ek, Petr Zahradník, Ji{hacek over (r)}í Malinak
  • Publication number: 20150251993
    Abstract: Iohexol particles, contrast agent compositions comprising iohexol particles, methods of preparing iohexol particles, and methods of administering iohexol particles are provided herein. The iohexol particles of the present invention substantially dissolve in water within about 60 seconds when tested using Modified United States Pharmacopeia Method 641.
    Type: Application
    Filed: March 4, 2015
    Publication date: September 10, 2015
    Inventors: Jirí PROKOP, Ivan HLAVÁCEK, Petr ZAHRADNÍK, Jirí MALINAK