Patents by Inventor Petrus J. Snijders

Petrus J. Snijders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Primers and process for detecting human papillomavirus genotypes by PCR
    Patent number: 5364758
    Abstract: The invention relates to primers and a method of detecting human papilloma virus (HPV) genotypes by means of the Polymerase Chain Reaction (PCR). The invention provides such primers and such PCR conditions that in principle any genital HPV genotype is detected. The general primers according to the invention consist of an oligonucleotide which comprises at the 3' end one of the sequences of SEQ ID NO: 3-6, or a sequence which is homologous to one of these four sequences as to at least 75%. In order to obtain amplification even in the case of a limited number of mismatches, in the PCR a relatively low annealing temperature of 30.degree.-50.degree. C. and a relatively high Mg.sup.+2 concentration of 2-10 mM are used. The invention enables a sensitive and reliable preselection of samples to be examined, such as cervical smears.
    Type: Grant
    Filed: July 16, 1992
    Date of Patent: November 15, 1994
    Assignee: Stichting Researchfonds Pathologie
    Inventors: Christophorus J. Meijer, Adrianus J. van den Brule, Jan M. Walboomers, Petrus J. Snijders