Patents by Inventor Philip B. McGlave

Philip B. McGlave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ex vivo culture of stem cells
    Patent number: 5922597
    Abstract: A method for the culture of hematopoietic cells is provided comprising culturing said cells in stromal conditioned medium comprising one or more cytokines selected from the group consisting of MIP-1.alpha., IL-3, SCF, BB10010 and PF-4, so that the ability of the stem cells to self-replicate and differentiate is maintained or the ability of the committed progenitors to expand and differentiate is maintained.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: July 13, 1999
    Assignee: Regents of the University of Minnesota
    Inventors: Catherine M. Verfaillie, Philip B. McGlave, Jeffrey S. Miller
  • Stroma-derived stem cell proteoglycan growth factor
    Patent number: 5605829
    Abstract: An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian hematopoietic cells. The composition disclosed is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: February 25, 1997
    Assignee: Regents of the University of Minnesota
    Inventors: Philip B. McGlave, Catherine M. Verfaillie, Pankaj Gupta
  • Stroma-derived proteoglycan containing composition which promotes differentiation and maintains the self-renewal capacity of long-term bone marrow culture-initiating cells
    Patent number: 5523286
    Abstract: An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian hematopoietic cells. The composition disclosed is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: June 4, 1996
    Assignee: Regents of the University of Minnesota
    Inventors: Philip B. McGlave, Catherine M. Verfaillie
  • Method for culturing hematopoietic cells
    Patent number: 5460964
    Abstract: A method for culturing mammalian hematopoietic, preferably stem cells, is provided comprising maintaining a population of human hematopoietic cells in a non-contacting relationship to a population of cultured stromal cells, which populations are in preferably liquid stromal growth medium connection, so that the ability of the stem cells in said population to differentiate and self-replicate is maintained during an extended culture period.
    Type: Grant
    Filed: March 17, 1993
    Date of Patent: October 24, 1995
    Assignee: Regents of the University of Minnesota
    Inventors: Philip B. McGlave, Catherine M. Verfaillie, Jeffrey S. Miller
  • Method for culturing human hematopoietic stem cells in vitro
    Patent number: 5436151
    Abstract: A method for culturing mammalian hematopoietic stem cells is provided comprising maintaining a population of human stem cells in fixed, non-contacting relationship to a population of cultured stromal cells, which populations are in liquid stromal growth medium connection, so that the ability of the stem cells to differentiate and self-replicate is maintained during an extended culture period.
    Type: Grant
    Filed: April 3, 1992
    Date of Patent: July 25, 1995
    Assignee: Regents of the University of Minnesota
    Inventors: Philip B. McGlave, Catherine M. Verfaillie, Jeffrey S. Miller