Abstract: Provided herein are methods and dose packs for the monitoring of medication adherence. In one aspect, the dose pack comprises comprise a multiplicity of doses of an agent and a multiplicity of doses of a marker and be configured to isolate a pair of at least one of the multiplicity of doses of the agent and at least one of the multiplicity of doses of the marker for co-administration of the pair to the subject according to the dosing schedule. In another aspect, the method comprises obtaining a sample from the subject subsequent to the conclusion of a monitoring window and analyzing the sample for the presence or absence of a marker or a degradation product thereof.

Abstract: Provided herein are methods and dose packs for the monitoring of medication adherence. In one aspect, the dose pack comprises comprise a multiplicity of doses of an agent and a multiplicity of doses of a marker and be configured to isolate a pair of at least one of the multiplicity of doses of the agent and at least one of the multiplicity of doses of the marker for co-administration of the pair to the subject according to the dosing schedule. In another aspect, the method comprises obtaining a sample from the subject subsequent to the conclusion of a monitoring window and analyzing the sample for the presence or absence of a marker or a degradation product thereof.

Abstract: Provided herein are methods and dose packs for the monitoring of medication adherence. In one aspect, the dose pack comprises comprise a multiplicity of doses of an agent and a multiplicity of doses of a marker and be configured to isolate a pair of at least one of the multiplicity of doses of the agent and at least one of the multiplicity of doses of the marker for co-administration of the pair to the subject according to the dosing schedule. In another aspect, the method comprises obtaining a sample from the subject subsequent to the conclusion of a monitoring window and analyzing the sample for the presence or absence of a marker or a degradation product thereof.

Abstract: Provided herein are methods and dose packs for the monitoring of medication adherence. In one aspect, the dose pack comprises comprise a multiplicity of doses of an agent and a multiplicity of doses of a marker and be configured to isolate a pair of at least one of the multiplicity of doses of the agent and at least one of the multiplicity of doses of the marker for co-administration of the pair to the subject according to the dosing schedule. In another aspect, the method comprises obtaining a sample from the subject subsequent to the conclusion of a monitoring window and analyzing the sample for the presence or absence of a marker or a degradation product thereof.

Abstract: A manifold comprises a conduit for conveying a fluid stream, a plurality of nozzles, and a plurality of valves. Each nozzle is connected to a corresponding port in the conduit, and each valve is connected to a corresponding nozzle. The ports can be disposed at discrete locations on two or more transverse planes of the conduit and such that no longitudinal, diametrical plane of the conduit passing through the center point of any one of the ports is coplanar with a longitudinal, diametrical plane of the conduit passing through the center point of a longitudinally adjacent port. Alternatively, the ports can be disposed at discrete locations on the conduit such that no longitudinal, diametrical plane of the conduit passing through the center point of any one of the ports is coplanar with a longitudinal, diametrical plane of the conduit passing through the center point of any other port.

Abstract: A color changing soap dispenser having a reservoir and a pump. The reservoir contains a color changing soap. The color changing soap contains a soap composition comprising water and a surfactant, an indicator dye which exhibits an observable color change at a color change pH, and a base selected from the group consisting of carbonate salts of group I and II elements, phosphate salts of group I and II elements, bicarbonate salts of group I and II elements, and hydroxide salts of group I and II elements. The color changing soap has a pH of greater than 7 and less than 13. The method of using the color changing soap is also disclosed.

Abstract: Surprisingly effective additive formulations for the reduction of highly undesirable yellowing or other discoloration of white, uncolored, polyurethane foam articles are provided. White polyurethane foam exhibits a susceptibility to yellowing and discoloration to a great extent, particularly in relatively short periods of time, than other types of polymeric articles. The inventive additives impart excellent low-discoloration properties over appreciable amounts of time of regular exposure to harmful elements, thereby according the pertinent industry a manner of providing white polyurethane foams for longer periods of time. Methods of producing such reliably white-colored polyurethane foams are also provided.

Abstract: An electrochemical amplification scheme for detecting very small amounts of redox-active molecules is disclosed. The reaction involves “recycling” of oxidized analyte molecules by way of a solution-phase electron exchange reaction with a sacrificial electron donor. The scheme relies heavily upon the action of a selective monolayer coating on the electrode that suppresses direct oxidation of the sacrificial donor but facilitates the oxidation of analyte molecules. The method is particularly useful for detection of hydroxymethylferrocene at a dodecanethiolate-coated gold electrode with ferrocyanide as the sacrificial electron donor.