Patents by Inventor Philippe Langella

Philippe Langella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11717543
    Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: August 8, 2023
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, ECOLE D'INGENIEURS DE PURPAN
    Inventors: Philippe Langella, Sylvie Miquel, Rebeca Martin Rosique, Luis Bermudez Humaran, Muriel Thomas, Harry Sokol, Frédéric Carvalho, Vassilia Theodorou
  • Publication number: 20230167401
    Abstract: The invention relates to a bacterium of the Christensenellaceae family, in particular of the genus Christensenella, or a composition containing same for use in the prevention and/or treatment of chronic inflammatory diseases and/or cancers in humans or animals.
    Type: Application
    Filed: March 11, 2020
    Publication date: June 1, 2023
    Inventors: Georges RAWADI, Sandrine Paule CLAUS, Laure RINALDI, Frédéric ELUSTONDO, Marion Sophie, Madeleine SOTO, Katy Nicole LECORF, Camille Muriel, Dominique, Mathilde KROPP, Philippe LANGELLA, Rebeca MARTIN ROSIQUE, Patrizia BRIGIDI
  • Publication number: 20230095683
    Abstract: The present invention relates to the preventive or curative treatment of metabolic syndrome and associated disorders, and inflammatory bowel diseases using Coprococcus bacteria and/or culture supernatants thereof.
    Type: Application
    Filed: March 4, 2021
    Publication date: March 30, 2023
    Inventors: HARRY SOKOL, ALLISON AGUS, CHLOÉ MICHAUDEL, JULIEN PLANCHAIS, PHILIPPE LANGELLA
  • Patent number: 11596657
    Abstract: The present invention relates to the preventive or curative treatment of metabolic syndrome and the associated disorders with AhR agonist or microorganism producing AhR agonist.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: March 7, 2023
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, SORBONNE UNIVERSITÉ, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Harry Sokol, Jane Mea Natividad, Bruno Lamas, Henri Duboc, Mathias Lavie-Richard, Marie-Laure Michel, Philippe Langella
  • Publication number: 20230036163
    Abstract: The present invention relates to an association of a bacterial strain of the species Faecalibacterium prausnitzii deposited with the CNCM under accession number CNCM I-4573 with mesalamine, or a derivative thereof, and in particular to the use of this association in the treatment and/or prevention of an inflammatory gastrointestinal disease in an individual.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 2, 2023
    Inventors: Christel ROUSSEAUX, Harry SOKOL, Pauline RUFFIE, Jean-Marc CHANTEL, Florian CHAIN, Philippe LANGELLA, Rebeca MARTIN-ROSIQUE
  • Publication number: 20220339207
    Abstract: The present invention relates to a composition for use thereof in the treatment and/or prevention of an inflammatory bowel disease in an individual, the composition comprising, in a physiologically acceptable medium, at least (I) (a) a first bacterial strain of the Faecalibacterium prausnitzii species, and/or (b) a culture supernatant of a first bacterial strain of the Faecalibacterium prausnitzii species; and (II) (a) a second bacterial strain chosen from the group consisting of Christensenella minuta and Christensenella timonensis, and mixtures thereof, and/or (b) a culture supernatant of a second bacterial strain chosen from the group consisting of Christensenella minuta and Christensenella timonensis, and mixtures thereof.
    Type: Application
    Filed: July 23, 2020
    Publication date: October 27, 2022
    Inventors: Philippe LANGELLA, Patrizia BRIGIDI, Rebeca MARTIN ROSIQUE
  • Patent number: 11471498
    Abstract: The present disclosure relates to a new probiotic strain of Lactobacillus brevis, isolated from pulque and exhibiting anti-cancer properties, as well as to compositions which contain said strain.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: October 18, 2022
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUTO POLITECNICO NACIONAL (IPN)
    Inventors: Luis Bermudez Humaran, Edgar Torres Maravilla, Philippe Langella, Maria Elena Sanchez-Pardo
  • Publication number: 20220162547
    Abstract: The present invention relates to the use of a bacterium of the genus Lactobacillus in the treatment of respiratory diseases in humans as well as in animals. in particular, a particular strain of this bacterium and pharmaceutical compositions comprising it are described.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 26, 2022
    Inventors: Geanncarlo LUGO, Lucie BERNARD, Olivier NEYROLLES, Muriel THOMAS, Philippe LANGELLA, Aude REMOT
  • Publication number: 20220143143
    Abstract: A method for treating a gluten-induced disease, such as celiac disease, in a subject in need thereof is provided. The method comprises administering to the subject at least one agent that activates aryl hydrocarbon receptor such as AhR agonists, bacterial probiotics with AhR agonist activity, and IL-22 agonists, polypeptides and nucleic acid.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 12, 2022
    Inventors: Jeremy Mark Wells, Philippe Langella, Harry Sokol, Elena Verdu, Bruno Lamas
  • Publication number: 20210401954
    Abstract: The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.
    Type: Application
    Filed: July 23, 2021
    Publication date: December 30, 2021
    Inventors: Luis G. BERMUDEZ-HUMARAN, Thibault ALLAIN, Isabelle FLORENT, Philippe LANGELLA, Philippe GRELLIER, Marie-Agnes TRAVERS, Bruno POLACK
  • Patent number: 11207358
    Abstract: The present invention relates to a composition comprising a given Lactobacillus rhamnosus strain and a given Lactobacillus paracasei strain wherein the ratio of the given Lactobacillus rhamnosus strain to the given Lactobacillus paracasei strain (LR?:LP?) is higher or equal to 8:1 and to methods thereof.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: December 28, 2021
    Assignee: COMPAGNIE GERVAIS DANONE
    Inventors: Tamara Smokvina, Rebeca Martin Rosique, Philippe Langella
  • Publication number: 20210393737
    Abstract: The development of obesity is still increasing worldwide. Likewise, metabolic syndrome, which is a collection of obesity-associated disorders, is associated with development of cardiovascular diseases, insulin resistance, hepatic steatosis, certain types of cancer and type 2 diabetes. Recently, seven peptides were isolated from F.prausnitzii and were shown as deriving from a single Microbial Anti-inflammatory Molecule (MAM). The inventors shows that L-MAM treatment prevented animals from development of High-Fat Diet-induced obesity. L-MAM treated mice significantly gained less weight throughout the gavage as compared to HFD-fed control experiment. The difference in body weight between L-MAM-treated animals on a HFD and the remaining animals is largely due to a significant reduction in the percentage of fat mass and a significant increase in the percentage of lean mass. Oral glucose tolerance testing (OGTT) revealed that chronic administration of L-MAM increased glucose tolerance.
    Type: Application
    Filed: September 24, 2019
    Publication date: December 23, 2021
    Inventors: Christophe HEYMES, Rémy BURCELIN, Jean-Marc CHATEL, Philippe LANGELLA
  • Patent number: 11166991
    Abstract: The invention relates to a novel bacterial strain deposited with the CNCM under number 1-4969. This strain has properties that are useful in the treatment of respiratory disorders. The invention also relates to compositions and uses of said strain.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: November 9, 2021
    Assignee: Institut National De La Recherche Agronomique
    Inventors: Muriel Thomas, Aude Remot-Brizion, Philippe Langella
  • Publication number: 20210268044
    Abstract: The present invention disclosure relates to a new probiotic strain of Lactobacillus brevis, isolated from pique and exhibiting anti-cancer properties, as welt as to compositions which contain said strain.
    Type: Application
    Filed: June 5, 2019
    Publication date: September 2, 2021
    Applicants: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUTO POLITECNICO NACIONAL (IPN)
    Inventors: Luis BERMUDEZ HUMARAN, Edgar TORRES MARAVILLA, Philippe LANGELLA, Maria Elena SANCHEZ-PARDO
  • Publication number: 20210268040
    Abstract: The present invention relates to a bacterial of the Streptococcus thermophilus species with reference CNRZ160, for use in the prevention and/or treatment of intestinal inflammation in an individual.
    Type: Application
    Filed: June 19, 2019
    Publication date: September 2, 2021
    Inventors: Dominique DARDEVET, Isabelle AUZELOUX, Marianne JARZAGUET, Jérémie DAVID, Jean-Marc CHATEL, Annie DARY-MOUROT, Claire CHERBUY, Philippe LANGELLA
  • Patent number: 11103564
    Abstract: The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH)enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: August 31, 2021
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, MUSEUM NATIONAL D'HISTOIRE NATURELLE, ECOLE NATIONALE VETERINAIRE D'ALFORT
    Inventors: Luis G. Bermudez-Humaran, Thibault Allain, Isabelle Florent, Philippe Langella, Philippe Grellier, Marie-Agnes Travers, Bruno Polack
  • Patent number: 11013783
    Abstract: A method for preventing or treating an inflammatory disease, such as inflammatory bowel disease and Crohn disease, is presented. The method includes administering to a patient a polypeptide having the amino acid sequence of SEQ ID NO: 1, a conservative derivative or a fragment thereof, a nucleic acid sequence encoding said polypeptide, a vector comprising said nucleic acid sequence or a host cell that has been transfected, infected or transformed by said nucleic acid sequence and/or by said vector.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: May 25, 2021
    Assignee: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Philippe Langella, Benedicte Pigneur-Arnaud, Jean-Marc Chatel, Elodie Quevrain, Philippe Seksik, Germain Trugnan, Florian Chain, Luis G Bermudez-Humaran, Marie-Anne Maubert, Christophe Michon, Harry Sokol
  • Patent number: 10918678
    Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: February 16, 2021
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
  • Publication number: 20200316138
    Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 8, 2020
    Inventors: Philippe LANGELLA, Sylvie MIQUEL, Rebeca MARTIN ROSIQUE, Luis BERMUDEZ HUMARAN, Muriel THOMAS, Harry SOKOL, Frédéric CARVALHO, Vassilia THEODOROU
  • Patent number: 10736927
    Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 11, 2020
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Harry Sokol, Mathias Lavie-Richard, Marie-Laure Michel, Bruno Michel Lamas, Philippe Langella