Patents by Inventor Philippe Langella

Philippe Langella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10918678
    Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: February 16, 2021
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
  • Publication number: 20200316138
    Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 8, 2020
    Inventors: Philippe LANGELLA, Sylvie MIQUEL, Rebeca MARTIN ROSIQUE, Luis BERMUDEZ HUMARAN, Muriel THOMAS, Harry SOKOL, Frédéric CARVALHO, Vassilia THEODOROU
  • Patent number: 10736927
    Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 11, 2020
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Harry Sokol, Mathias Lavie-Richard, Marie-Laure Michel, Bruno Michel Lamas, Philippe Langella
  • Publication number: 20200155622
    Abstract: The present invention relates to the use of at least one Lactobacillus bacterium, or a composition comprising thereof or conditioned thereby, for decreasing a population of Bilophila wadsworthia or inhibiting the growth thereof
    Type: Application
    Filed: May 22, 2017
    Publication date: May 21, 2020
    Inventors: Harry SOKOL, Philippe LANGELLA, Jane NATIVIDAD, Patrick VEIGA, Johan VAN HYLCKAMA VLIEG
  • Publication number: 20200078420
    Abstract: The present invention relates to a composition comprising a given Lactobacillus rhamnosus strain and a given Lactobacillus paracasei strain wherein the ratio of said given Lactobacillus rhamnosus strain to said given Lactobacillus paracasei strain (LR?:LP?) is higher or equal to 8:1.
    Type: Application
    Filed: December 16, 2016
    Publication date: March 12, 2020
    Inventors: Tamara SMOKVINA, Rebeca MARTIN ROSIQUE, Philippe LANGELLA
  • Publication number: 20190381115
    Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
    Type: Application
    Filed: November 13, 2015
    Publication date: December 19, 2019
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), ECOLE D'INGENIEURS DE PURPAN
    Inventors: Philippe LANGELLA, Sylvie MIQUEL, Rebeca MARTIN ROSIQUE, Luis BERMUDEZ HUMARAN, Muriel THOMAS, Harry SOKOL, Frédéric CARVALHO, Vassilia THEODOROU
  • Publication number: 20190323860
    Abstract: The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH)enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 24, 2019
    Inventors: Luis G. BERMUDEZ-HUMARAN, Thibault ALLAIN, Isabelle FLORENT, Philippe LANGELLA, Philippe GRELLIER, Marie-Agnes TRAVERS, Bruno POLACK
  • Publication number: 20190282638
    Abstract: The present invention relates to the preventive or curative treatment of metabolic syndrome and the associated disorders with AhR agonist or microorganism producing AhR agonist.
    Type: Application
    Filed: July 11, 2017
    Publication date: September 19, 2019
    Inventors: HARRY SOKOL, JANE MEA NATIVIDAD, BRUNO LAMAS, HENRI DUBOC, MATHIAS LAVIE-RICHARD, MARIE-LAURE MICHEL, PHILIPPE LANGELLA
  • Patent number: 10328132
    Abstract: The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: June 25, 2019
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, MUSEUM NATIONAL D'HISTOIRE NATURELLE, ECOLE NATIONALE VETERINAIRE D'ALFORT
    Inventors: Luis G. Bermudez-Humaran, Thibault Allain, Isabelle Florent, Philippe Langella, Philippe Grellier, Marie-Agnes Travers, Bruno Polack
  • Patent number: 10238697
    Abstract: The present invention relates to recombinant Lactococcus lactis bacteria expressing and secreting TSLP or IL-25 or a combination thereof, and their use as probiotics or therapeutic agents, especially for use in the treatment of inflammatory diseases and disorders.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: March 26, 2019
    Assignee: ARES TRADING S.A.
    Inventors: Philippe Langella, Jean-Marc Chatel, Luis Bermudez-Humaran, Camille Aubry, Laurence Goffin, Simone Favre-Zimmerli, Yolande Chvatchko
  • Publication number: 20190030089
    Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
    Type: Application
    Filed: January 23, 2017
    Publication date: January 31, 2019
    Applicants: Institut National De La Recherche Agronomique (INRA), Sorbonne Universite, Assistance Publique - Hopitaux de Paris
    Inventors: Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
  • Publication number: 20190030094
    Abstract: The invention relates to a novel bacterial strain deposited with the CNCM under number 1-4969. This strain has properties that are useful in the treatment of respiratory disorders. The invention also relates to compositions and uses of said strain.
    Type: Application
    Filed: January 27, 2017
    Publication date: January 31, 2019
    Inventors: Muriel Thomas, Aude Remot-Brizion, Philippe Langella
  • Publication number: 20180250350
    Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
    Type: Application
    Filed: August 22, 2016
    Publication date: September 6, 2018
    Inventors: HARRY SOKOL, MATHIAS LAVIE-RICHARD, MARIE-LAURE MICHEL, BRUNO MICHEL LAMAS, PHILIPPE LANGELLA
  • Publication number: 20180104285
    Abstract: The present invention relates to recombinant Lactococcus lactis bacteria expressing and secreting TSLP or IL-25 or a combination thereof, and their use as probiotics or therapeutic agents, especially for use in the treatment of inflammatory diseases and disorders.
    Type: Application
    Filed: April 12, 2016
    Publication date: April 19, 2018
    Inventors: PHILIPPE LANGELLA, JEAN-MARC CHATEL, LUIS BERMUDEZ-HUMARAN, CAMILLE AUBRY, LAURENCE GOFFIN, SIMONE FAVRE-ZIMMERLI, YOLANDE CHVATCHKO
  • Publication number: 20180092949
    Abstract: The present invention relates to a composition comprising a therapeutically effective amount of Bacteroides thetaiotaomicron or an extract thereof for use in the prevention or treatment of an infection in a subject who is immunodepressed, who is immunosuppressed, who has an immature immune system, and/or who has a weakness, and in which the composition comprises at most six species of bacteria and/or extracts thereof. The infections concerned are mainly intestinal infections, in particular those which affect non-human mammals and/or humans.
    Type: Application
    Filed: April 22, 2016
    Publication date: April 5, 2018
    Inventors: HARRY SOKOL, PHILIPPE LANGELLA, THOMAS WALTER HOFFMANN, CHANTAL BRIDONNEAU, HANG PHUONG PHAM, MATHIAS LAVIE-RICHARD
  • Publication number: 20180085429
    Abstract: A method for preventing or treating an inflammatory disease, such as inflammatory bowel disease and Crohn disease, is presented. The method includes administering to a patient a polypeptide having the amino acid sequence of SEQ ID NO: 1, a conservative derivative or a fragment thereof, a nucleic acid sequence encoding said polypeptide, a vector comprising said nucleic acid sequence or a host cell that has been transfected, infected or transformed by said nucleic acid sequence and/or by said vector.
    Type: Application
    Filed: November 3, 2017
    Publication date: March 29, 2018
    Inventors: Philippe LANGELLA, Benedicte PIGNEUR-ARNAUD, Jean-Marc CHATEL, Elodie QUEVRAIN, Philippe SEKSIK, Germain TRUGNAN, Florian CHAIN, Luis G BERMUDEZ-HUMARAN, Marie-Anne MAUBERT, Christophe MICHON, Harry SOKOL
  • Publication number: 20170216415
    Abstract: The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.
    Type: Application
    Filed: August 10, 2015
    Publication date: August 3, 2017
    Inventors: Luis G. BERMUDEZ-HUMARAN, Thibault ALLAIN, Isabelle FLORENT, Philippe LANGELLA, Philippe GRELLIER, Marie-Agnes TRAVERS, Bruno POLACK
  • Patent number: 9688742
    Abstract: The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: June 27, 2017
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), UNIVERSITE PARIS DIDEROT—Paris 7
    Inventors: Nathalie Vergnolle, Jean-Michel Sallenave, Philippe Langella, Luis Bermudez-Humaran
  • Publication number: 20150335705
    Abstract: A polypeptide including or consisting of the amino acid sequence SEQ ID NO: 1, for use in the treatment or prevention of an inflammatory disease. A nucleic acid sequence encoding the polypeptide, a vector including the nucleic acid and a host cell including the nucleic acid sequence and/or a vector, for use in the treatment or prevention of an inflammatory disease are also described. A pharmaceutical composition including the polypeptide, the nucleic acid sequence, the vector or the host cell and a pharmaceutically acceptable carrier, for the treatment of inflammatory disease are also disclosed.
    Type: Application
    Filed: December 26, 2013
    Publication date: November 26, 2015
    Inventors: Philippe LANGELLA, Benedicte PIGNEUR-ARNAUD, Jean-Marc CHATEL, Elodie QUEVRAIN, Philippe SEKSIK, Germain TRUGNAN, Florian CHAIN, Luis G BERMUDEZ-HUMARAN, Marie-Anne MAUBERT, Christophe MICHON, Harry SOKOL
  • Publication number: 20150139940
    Abstract: The invention relates to prokaryotic expression cassettes comprising a stress-regulated promoter, the promoter of the GroESL operon of Lactococcus lactis. Said cassettes can be used for the expression of genes of interest in gram-positive bacteria, and especially for producing and releasing a protein of interest when the bacteria are administered to an individual.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 21, 2015
    Inventors: Luis Bermudez Humaran, Philippe Langella, Pascale Kharrat