Abstract: A computer-implemented method of providing limited distribution of a digital media file, the method being executable at a server connected to a network, the server comprising memory. The method includes receiving the digital media file to be distributed; encrypting the digital media file to create an encrypted digital media file; creating a plurality of copies of the encrypted digital media file; creating a plurality of rights tokens, a quantity of the rights tokens being equal to a quantity of copies of the encrypted digital media file, each rights token containing: a key for decrypting a corresponding one of the plurality of copies of the encrypted digital media file, and identifying information related to access rights for the digital media file; and recording the rights tokens to a rights blockchain representative of actions related to distribution of the plurality of copies of the encrypted the digital media file.

Abstract: A computer-implemented method of providing limited distribution of a digital media file, the method being executable at a server connected to a network, the server comprising memory. The method includes receiving the digital media file to be distributed; encrypting the digital media file to create an encrypted digital media file; creating a plurality of copies of the encrypted digital media file; creating a plurality of rights tokens, a quantity of the rights tokens being equal to a quantity of copies of the encrypted digital media file, each rights token containing: a key for decrypting a corresponding one of the plurality of copies of the encrypted digital media file, and identifying information related to access rights for the digital media file; and recording the rights tokens to a rights blockchain representative of actions related to distribution of the plurality of copies of the encrypted the digital media file.

Abstract: A computer-implemented method of providing limited distribution of a digital media file, the method being executable at a server connected to a network, the server comprising memory. The method includes receiving the digital media file to be distributed; encrypting the digital media file to create an encrypted digital media file; creating a plurality of copies of the encrypted digital media file; creating a plurality of rights tokens, a quantity of the rights tokens being equal to a quantity of copies of the encrypted digital media file, each rights token containing: a key for decrypting a corresponding one of the plurality of copies of the encrypted digital media file, and identifying information related to access rights for the digital media file; and recording the rights tokens to a rights blockchain representative of actions related to distribution of the plurality of copies of the encrypted the digital media file.

Abstract: Medical plugs for filling a void within a patient. Medical plugs may include a channel that extends from a proximal end to a distal end of the medical plug. The medical plug may include multiple channels. The channels may be disposed on the outer surface of the medical plug or may be disposed within medical plug. A medical plug delivery system may deliver the medical plug, and medical plug delivery system may include a plug holder with a lumen. Medical plug may be housed within the lumen of a plug holder and may be frictionally engaged with the lumen. When the medical plug is wetted, the medical plug may swell and close off the channel. A kit comprising a vacuum sealed flexible enclosure may be used to prevent displacement of the medical plug within the lumen during shipping and handling.

Abstract: A process for the conversion of carbon-based material to fuel bases by a hybrid route combining direct ebullent bed liquefaction and indirect liquefaction by gasification followed by a Fischer-Tropsch synthesis, including a stage of production of hydrogen resulting from non-fossil resources and a reverse water gas reaction stage. This process makes it possible to limit emissions of greenhouse gases.

Abstract: The present invention concerns an improved once-through process for hydrocracking hydrocarbon-containing feeds with high nitrogen contents, with partial elimination of ammonia, for example by a hot flash located between the hydrorefining zone and the hydrocracking zone. Said hot flash drum functions at a pressure close to that of the hydrorefining reactor and at a temperature in the range from 150° C. to the hydrorefining reactor outlet temperature.

Abstract: A plasticized polymer of PLGA employing ethanol as the plasticizing agent prepared at a temperature higher than the Tg and lower than the boiling point of ethanol can be used in subcutaneous implants containing active ingredients therein.

Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.

Abstract: Subcutaneous implants obtained by extrusion containing an active ingredient dispersed in a PLGA matrix obtained by grinding an extruded product consisting of a blend of: at least two PLGA having different lactic acid/glycolic acid molar ratios and different weight average molecular weights, or a PLGA and PLA having different weight average molecular weight.

Abstract: Subcutaneous implants obtained by extrusion containing (1) microparticles 5 containing an active ingredient dispersed in a PLGA matrix, and optionally microparticles (2) consisting of the same active ingredient or (2?) of a different active ingredient preferably belonging to the same category as that contained in (1) all said microparticles (1) being dispersed in a matrix of PLGA (3), having a glass transition temperature lower than that of the PLGA contained in (1).

Abstract: Subcutaneous implants obtained by extrusion containing an active ingredient, and a hydrophilic excipient dispersed in a PLGA matrix so that the weight ratio: (Active Ingredient (AI)+Excipient (E))/PLGA is higher than 0.05 and lower than 1.

Abstract: The invention relates to a process and installation for treating heavy petroleum feedstocks for producing a gas oil fraction that has a sulfur content of less than 50 ppm and most often 10 ppm that includes the following stages: a) mild hydrocracking in a fixed catalyst bed, b) separation from hydrogen sulfide of a distillate fraction that includes a gas oil fraction and a heavier fraction than the gas oil, c) hydrotreatment (including desulfurization) of said distillate fraction, and d) separation of a gas oil fraction with less than 50 ppm of sulfur. Advantageously, the heavy fraction is sent into catalytic cracking. The process preferably operates with make-up hydrogen that is brought to stage c), and very advantageously all of the make-up hydrogen of the process in introduced in stage c).

Abstract: The invention relates to a process for treating heavy petroleum feedstocks for producing a gas oil fraction that has a sulfur content of less than 50 ppm and most often 10 ppm that includes the following stages: a) ebulliated-bed catalytic hydrocracking, b) separation from hydrogen sulfide of a distillate fraction that includes a gas oil fraction and a heavier fraction than the gas oil, c) hydrotreatment of said distillate fraction, and d) separation of a gas oil fraction with less than 50 ppm of sulfur. Make-up hydrogen, preferably all make-up hydrogen, is to stage c). Advantageously, the heavier fraction from step (b) is subjected to catalytic cracking. The invention also relates to an installation that can be used for implementing this process.

Abstract: Process for transforming a gas-oil fraction that makes it possible to produce a fuel that has a quality according to stringent requirements in terms of sulfur content, aromatic compound content, cetane number, boiling point, T95, of 95% of the compounds and density, d15/4, at 15° C. This process comprises a hydrorefining stage and a hydrocracking stage, whereby the latter uses a catalyst that contains at least one zeolite. The conversion of products that have a boiling point of less than 150° C. is, throughout the two stages of hydrocracking and hydrorefining, less than 40% by weight and, for the hydrorefining stage, between 1 and 15% by weight. The temperature, TR2, of the hydrocracking stage is less than the temperature, TR1, of the hydrorefining stage, and the variation between temperatures TR1 and TR2 is between 0 and 80° C.

Abstract: A process for production of very high-quality base oils, and simultaneous production of high-quality middle distillates, comprises the successive stages of hydroisomerization and catalytic dewaxing. The hydroisomerization takes place in the presence of a catalyst containing at least one noble metal deposited on an amorphous acid support, the metal dispersion being less than 20%. The support is preferably an amorphous silica-alumina. The catalytic dewaxing takes place in the presence of a catalyst containing at least one hydrodehydrogenating element (Group VIII) and at least one molecular sieve chosen from ZBM-30, EU-2, and EU-11.

Abstract: Process for transforming a gas oil fraction that makes it possible to produce a fuel that has a quality according to stringent requirements in terms of sulfur content, aromatic compound content, cetane number, boiling point, T95, of 95% of the compounds and density, d15/4, at 15° C. This process comprises a hydrorefining stage and a subsequent stage, whereby the latter uses a catalyst that is selected from the group that consists of hydrorefining catalysts and catalysts that comprise at least one mixed oxide, a metal of group VIB, and a non-noble metal of group VIII. The conversion of products that have a boiling point of less than 150° C. is, for the hydrorefining stage, between 1 and 15% by weight. The temperature, TR2, of the subsequent stage is less than the temperature, TR1, of the hydrorefining stage, and the variation between temperatures TR1 and TR2 is between 0 and 80° C.

Abstract: For producing very high quality base stock and for simultaneously producing high quality middle distillates, successive hydroisomerisation and catalytic dewaxmg steps are employed wherein the hydroisomerisation is carried out in the presence of a catalyst containing at least one noble metal deposited on an amorphous acidic support, the dispersion of the metal being 20%-100%. The support is preferably an amorphous silica-alumina. Catalytic dewaxing is carried out in the presence of a catalyst containing at least one hydrodehydrogenating element (group VIII) and at least one molecular sieve selected from ZBM-30, EU-2 and EU-11.

Abstract: For producing basic oils and in particular very high quality oils, i.e. oils possessing a high viscosity index (VI), a low aromatics content, good UV stability and a low pour point, from oil cuts having an initial boiling point higher than 340° C., possibly with simultaneous production of middle distillates (in particular gasoils and kerosene) of very high quality, i.e. having a low aromatics content and a low pour point, the invention provides a flexible procedure for producing oils and middle distillates from a charge containing heteroatoms, i.e. containing more than 200 ppm by weight of nitrogen, and more than 500 ppm by weight of sulphur. The procedure comprises at least one hydrorefining stage, at least one stage of catalytic dewaxing on zeolite, and at least one hydrofinishing stage.

Abstract: Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof consisting of: a core (i) comprising an active principle dispersed in a polymeric matrix of polylactic-glycolic acid (PLGA) copolymer, a coating in film form (ii), comprising as the main component a lactic-glycolic acid copolymer, and the relative processes for preparing said implants.

Abstract: An improved hydrocracking process of hydrocarbon charges, in two stages with an intermediate separation, in which the second-stage of hydrocracking is carried out in the presence of an added nitrogen content which is greater than 150 ppm by weight, preferably about 500 ppm by weight, and preferably in the presence of a Y zeolite catalyst, produces high yields of middle distillate.