Patent number: 6569858
Abstract: A compound selected from those of formula (I):
wherein:
R1 and R2, which may be identical or different, represent a group of formula U-V wherein U represents single bond, or alkylene which is optionally substituted and/or unsaturated, and V is as defined in the description,
G represents oxygen, or NR3 wherein R3 is as defined in the description,
X represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y represents hydrogen, or X+Y represents carbonyl,
X1 represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1 represents hydrogen, or X1+Y1 represents carbonyl,
R4, R5, and R6 are as defined in the description,
its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same are useful in the treatment of cancer.
Type:
Grant
Filed:
November 5, 2001
Date of Patent:
May 27, 2003
Assignee:
Les Laboratoires Servier
Inventors:
Michelle Prudhomme, Pascale Moreau, Fabrice Anizon, Christelle Marminon, Ghanem Atassi, Alain Pierre, Bruno Pfeiffer, Pierre Renard
Patent number: 6503919
Abstract: A compound selected from those of formula (I):
wherein:
X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy,
R1 represents hydrogen, or alkyl,
R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted amino,
R3 and R4 represent hydrogen, or alkyl,
R5 and R6 represent —O—CO—U—V wherein U and V are as defined in the description, or Z as defined in the description, it being understood that at least one of the R5 and R6 groups represents —O—CO—U—V,
their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of cancer.
Type:
Grant
Filed:
June 15, 2000
Date of Patent:
January 7, 2003
Assignee:
Les Laboratoires Server
Inventors:
Michel Koch, François Tillequin, Sylvie Michel, Ghanem Atassi, Alain Pierre, Pierre Renard, Bruno Pfeiffer
Patent number: 6451789
Abstract: Compound of formula (I):
wherein:
n represents 0 or 1,
R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl,
R2 represents alkyl,
X represents oxygen, chlorine, OR3, SR4 or NOR5,
R3 represents hydrogen , alkyl, acyl, alkoxycarbonyl or arylalkoxycarbonyl,
R4 represents hydrogen, alkyl or aryl,
R5 represents hydrogen or optionally substituted alkyl,
represents a single or double bond,
Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful as facilitators of memory and cognition and antalgic agents.
Type:
Grant
Filed:
September 26, 2001
Date of Patent:
September 17, 2002
Assignee:
Les Labortoires Servier
Inventors:
Sylvain Rault, Olivier Renault, Jean Guillon, Patrick Dallemagne, Pierre Renard, Bruno Pfeiffer, Pierre Lestage, Marie-Cécile Lebrun
