Patents by Inventor Piotr Kowalczyk
Piotr Kowalczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11345669Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.Type: GrantFiled: March 12, 2018Date of Patent: May 31, 2022Assignee: NodThera LimitedInventors: David Harrison, Alan Paul Watt, Nicolas Boutard, Charles-Henry Fabritius, Michal Galezowski, Piotr Kowalczyk, Oleksandr Levenets, Jakub Woyciechowski
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Publication number: 20200131141Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.Type: ApplicationFiled: March 12, 2018Publication date: April 30, 2020Inventors: David HARRISON, Alan Paul WATT, Nicolas BOUTARD, Charles-Henry FABRITIUS, Michal GALEZOWSKI, Piotr KOWALCZYK, Oleksandr LEVENETS, Jakub WOYCIECHOWSKI
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Patent number: 8393528Abstract: A method for hardfacing a metal component surface (14, 16), especially a shroud surface of a turbine blade made of a TiAl alloy, with at least one metal material (18, 20), in particular a Co—Cr alloy. The hardfacing coating is produced separately from the component surface and is then joined to the component surface in a high-temperature soldering process. A turbine blade including such a hardfacing coating, primarily in a shroud region (2).Type: GrantFiled: July 8, 2010Date of Patent: March 12, 2013Assignee: MTU Aero Engines GmbHInventors: Karl-Hermann Richter, Ulrich Knott, Piotr Kowalczyk
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Publication number: 20120125980Abstract: A method for hardfacing a metal component surface (14, 16), especially a shroud surface of a turbine blade made of a TiAl alloy, with at least one metal material (18, 20), in particular a Co—Cr alloy. The hardfacing coating is produced separately from the component surface and is then joined to the component surface in a high-temperature soldering process. A turbine blade including such a hardfacing coating, primarily in a shroud region (2).Type: ApplicationFiled: July 8, 2010Publication date: May 24, 2012Applicant: MTU Aero Engines GmbHInventors: Karl-Hermann Richter, Ulrich Knott, Piotr Kowalczyk
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Patent number: 7629370Abstract: The invention relates to a method of treatment and/or prophylaxis of diseases and conditions mediated by peroxysome proliferator-activated receptor gamma (PPAR?) in a mammal subject in need thereof, said method comprising administration to said mammal a compound of formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically or prophylactically effective amount wherein in formula (I) W represents a COOH group or its bioisosters, or COO—C1-C4-alkyl group; Y represents NH or N—C1-C10-alkyl; Z represents NH, N—C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1-C10-alkyl, N-aryl, NSO2—C1-C10-alkyl, N—SO2-aryl, or N S02-heteroaryl; R1 to R6 each independently represents a hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive. The compounds of formula (I) are the ligands of PPAR-gamma receptor.Type: GrantFiled: March 6, 2007Date of Patent: December 8, 2009Assignee: Adamed Sp. z o.o.Inventors: Zbigniew Majka, Katarzyna Ewa Rusin, Dominik Daniel Kludkiewicz, Krzysztof Kurowski, Katarzyna Joanna Matusiewicz, Tomasz Stawinski, Daniel Sulikowski, Piotr Kowalczyk
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Patent number: 7312338Abstract: The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1-C4-alkyl group; Y represents NH, N—C1-C10-alkyl, O, or S; Z represents NH, N—C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1-C10-alkyl, N-aryl, NSO2—C1-C10-alkyl, N—SO2-aryl, or N—SO2-heteroaryl; R1 to R8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof.Type: GrantFiled: December 8, 2005Date of Patent: December 25, 2007Assignee: Adamed, Sp. z.o.o.Inventors: Zbigniew Majka, Katarzyna Ewa Rusin, Andrzej Wojciech Sawicki, Krzysztof Kurowski, Katarzyna Joanna Matusiewicz, Tomasz Stawinski, Daniel Sulikowski, Piotr Kowalczyk
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Patent number: 7309791Abstract: The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1–C4-alkyl group; Y represents NH, N—C1–C10-alkyl, O, or S; Z represents NH, N—C1–C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1–C10-alkyl, N-aryl, NSO2—C1–C10-alkyl, N—SO2-aryl, or N—SO2-heteroaryl; R1, to R6 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.Type: GrantFiled: January 12, 2006Date of Patent: December 18, 2007Assignee: Adamed Sp. z.o.oInventors: Zbigniew Majka, Katarzyna Ewa Rusin, Dominik Daniel Kludkiewicz, Krzysztof Kurowski, Katarzyna Joanna Matusiewicz, Tomasz Stawinski, Daniel Sulikowski, Piotr Kowalczyk
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Publication number: 20070161799Abstract: The invention relates to a method of treatment and/or prophylaxis of diseases and conditions mediated by peroxysome proliferator-activated receptor gamma (PPAR?) in a mammal subject in need thereof, said method comprising administration to said mammal a compound of formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically or prophylactically effective amount wherein in formula (I) W represents a COOH group or its bioisosters, or COO—C1-C4-alkyl group; Y represents NH or N—C1-C10-alkyl; Z represents NH, N—C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1-C10-alkyl, N-aryl, NSO2—C1-C10-alkyl, N—SO2-aryl, or N S02-heteroaryl; R1 to R6 each independently represents a hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive. The compounds of formula (I) are the ligands of PPAR-gamma receptor.Type: ApplicationFiled: March 6, 2007Publication date: July 12, 2007Applicant: ADAMED, Sp. z o.o.Inventors: Zbigniew Majka, Katarzyna Rusin, Dominik Kludkiewicz, Krzysztof Kurowski, Katarzyna Matusiewicz, Tomasz Stawinski, Daniel Sulikowski, Piotr Kowalczyk
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Patent number: 7220766Abstract: The invention relates to new compounds, 3-phenylpropionic acid derivatives of formula (I) wherein W represents COOH group or its bioisosters, or —COO—C1–C4-alkyl group; Y represents NH, N—C1–C10-alkyl, O, or S; X represents O, S, NH, N—C1–C10-alkyl, N-aryl, NSO2—C1–C10-alkyl, N—SO2-aryl, or N—SO2-heteroaryl; R1 to R8 each independently represents hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof.Type: GrantFiled: January 12, 2006Date of Patent: May 22, 2007Assignee: ADAMED, Sp. z.o.o.Inventors: Zbigniew Majka, Katarzyna Ewa Rusin, Andrzej Wojciech Sawicki, Krzysztof Kurowski, Katarzyna Joanna Matusiewicz, Tomasz Stawinski, Daniel Sulikowski, Dominik Daniel Kludkiewicz, Piotr Kowalczyk