Patents by Inventor Piyasena Hewawasam

Piyasena Hewawasam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080227769
    Abstract: The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: February 28, 2008
    Publication date: September 18, 2008
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080226593
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 18, 2008
    Inventors: Piyasena Hewawasam, Yong Tu
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080226592
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 18, 2008
    Inventors: Kap-Sun Yeung, John A. Bender, Robert G. Gentles, Zhong Yang, Min Ding, Yong Tu, Piyasena Hewawasam, Ying Han, John F. Kadow
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080226591
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 18, 2008
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7399758
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: July 15, 2008
    Inventors: Nicholas A. Meanwell, Robert G. Gentles, Min Ding, John A. Bender, John F. Kadow, Piyasena Hewawasam, Thomas W. Hudyma, Xiaofan Zheng
  • CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS
    Publication number: 20080146537
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 19, 2008
    Inventors: John A. Bender, Min Ding, Robert G. Gentles, Piyasena Hewawasam
  • Inhibitors of HCV replication
    Patent number: 7348425
    Abstract: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: March 25, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, Feng He, Min Ding, Carl P. Bergstrom, Piyasena Hewawasam, Scott W. Martin, Robert G. Gentles
  • Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors
    Publication number: 20070275930
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: May 23, 2007
    Publication date: November 29, 2007
    Inventors: Robert G. Gentles, Min Ding, Piyasena Hewawasam
  • Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors
    Publication number: 20070270406
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: May 7, 2007
    Publication date: November 22, 2007
    Inventors: Robert G. Gentles, Piyasena Hewawasam, Min Ding, Carl P. Bergstrom, Scott W. Martin, Kap-Sun Yeung, Thomas W. Hudyma, Xiaofan Zheng, John A. Bender, John F. Kadow
  • Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors
    Publication number: 20070270405
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: May 3, 2007
    Publication date: November 22, 2007
    Inventors: John A. Bender, Min Ding, Robert G. Gentles, Piyasena Hewawasam
  • Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors
    Publication number: 20070184024
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 12, 2007
    Publication date: August 9, 2007
    Inventors: Nicholas Meanwell, Robert Gentles, Min Ding, John Bender, John Kadow, Piyasena Hewawasam, Thomas Hudyma, Xiaofan Zheng
  • Indolobenzazepine HCV NS5B inhibitors
    Publication number: 20070078122
    Abstract: The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: September 6, 2006
    Publication date: April 5, 2007
    Inventors: Carl Bergstrom, John Bender, Robert Gentles, Piyasena Hewawasam, Thomas Hudyma, John Kadow, Scott Martin, Alicia Regueiro-Ren, Kap-Sun Yeung, Yong Tu, Katharine Grant-Young, Xiaofan Zheng
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Publication number: 20070060565
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: August 22, 2006
    Publication date: March 15, 2007
    Inventors: Nicholas Meanwell, Robert Gentles, Min Ding, John Bender, John Kadow, Piyasena Hewawasam, Thomas Hudyma, Xiaofan Zheng
  • 3-thia-4-arylquinolin-2-one derivatives
    Patent number: 7179920
    Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: February 20, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kenneth M. Boy, Piyasena Hewawasam, Sing-Yuen Sit
  • N-substituted prodrugs of fluorooxindoles
    Patent number: 7169803
    Abstract: The present invention provides novel N-substituted fluorooxindoles having the general Formula I wherein the wavy bond represents the racemate, the (R)-enantiomer or the (S)-enantiomer and m, n, p, q, A, B, D, Q, X, and Z are as defined below, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: January 30, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Starrett, Jr., Omar D. Lopez, Piyasena Hewawasam, Min Ding
  • Hepatitis C virus inhibitors
    Publication number: 20070010455
    Abstract: The present disclosure relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Application
    Filed: July 6, 2006
    Publication date: January 11, 2007
    Inventors: Piyasena Hewawasam, Min Ding, Li-Qiang Sun, Paul Scola
  • Inhibitors of HCV replication
    Patent number: 7153848
    Abstract: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: December 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, Feng He, Min Ding, Carl P. Bergstrom, Piyasena Hewawasam, Scott W. Martin, Robert G. Gentles
  • Potassium channel modulators
    Patent number: 7151180
    Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: December 19, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Piyasena Hewawasam, Sing-Yuen Sit, John E. Starrett, Jr.
  • Hepatitis C virus inhibitors
    Patent number: 7132504
    Abstract: Compounds are disclosed having the general formula: wherein R1, R2, R3, R4, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: November 7, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Paul Michael Scola, Fiona McPhee, Nicholas A Meanwell, Piyasena Hewawasam, Jeffrey Allen Campbell
  • Hepatitis C virus inhibitors
    Publication number: 20060172950
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: December 7, 2005
    Publication date: August 3, 2006
    Inventors: Xiangdong Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Scola, Piyasena Hewawasam, Andrew Good, Yan Chen, Jeffrey Campbell