Abstract: A system and a method for parameter optimization with adaptive search space and a user interface using the same are provided. The system includes a data acquisition unit, an adaptive adjustment unit and an optimization search unit. The data acquisition unit obtains a set of executed values of several operating parameters and a target parameter. The adaptive adjustment unit includes a parameter space transformer and a search range definer. The parameter space transformer performs a space transformation on a parameter space of the operating parameters according to the executed values. The search range definer defines a parameter search range in a transformed parameter space based on the sets of the executed values. The optimization search unit takes the parameter search range as a limiting condition and takes optimizing the target parameter as a target to search for a set of recommended values of the operating parameters.

Abstract: A surface-treated intervertebral fusion cage is provided, including a main body and a porous structure portion. The porous structure portion is arranged at the corresponding position of the upper and lower parts of the main body. The surface-treated intervertebral fusion cage can improve the biocompatibility, and the surface etching and thermal treatment can increase the coating coverage and increase the mechanical toughness of the cage of the present invention.

Abstract: A flexible intervertebral cage with opening is provided, including a main body, a porous structure part, a side opening, and a rear opening. The porous structure part is arranged at the corresponding positions of the upper and lower parts of the main body; the side opening are located on the two sides of the main body that are different from the upper and lower parts, and the rear opening is located at the other ends of the upper and lower parts of the main body opposite to the end part that connects the upper and lower part. As such, a C-shaped opening structure is used to effectively reduce stress shielding and stress transfer. The biomimetic porous structure of the structural part can promote the attachment and growth of bone cells.

Abstract: The present invention relates to a glass-ceramic composite material, which is a composite material with degradability and osteoconductivity, and is composed of CaO—MgO—SiO2 (CMS glass)+CaMgSi2O6 (CMS ceramic) and CaSO4 (CS ceramic). In addition to the CaO—MgO—SiO2 glass, this synthesized composite material mainly includes two ceramics of CaMgSi2O6 and CaSO4 in crystalline phase, wherein, both the CMS glass and CMS ceramic have high mechanical strength, biocompatibility and osteoconductivity, while CaSO4 has the characteristics of rapid degradation to promote bone ingrowth.

Abstract: A dual-trajectory pedicle screw system includes an internally threaded sleeve and including first part and cylindrical second part, the first part being recessed to form a space, and the second part including projections on top; a main screw including a universal head and a first conic member, the universal head including first and second threaded holes, the first threaded hole being inclined at a first angle, the second threaded hole being inclined at a different second angle, bottom of the universal head being a convex and rotatably disposed in the space; and an auxiliary screw including external threads threadedly secured to the first or second threaded hole so that the auxiliary screw is secured to the main screw at the first or second angle with respect to the main screw, a second conic member extending downward from the external threads, and a fitting member on top of the external threads.

Abstract: The present invention provides a pedicle screw, which includes a screw head, a screw body, a screw rod and a screw cap. The screw body includes a ball-liked arc-shaped buckle portion and a column-liked thread portion. The screw head includes a semi-sphere part with an arc-shaped dimple on one end and a U-shaped cavity on the other end. The U-shaped cavity connects with the arc-shaped dimple. Furthermore, the Arc-shaped dimple connects with the arc-shaped buckle portion. The Arc-shaped dimple includes an opening on its top to allow the screw body passing through. The U-shaped cavity includes an opening, which includes a female thread to fix the screw rod in the U-shaped cavity by a male thread on the screw cap.

Abstract: A spine correction apparatus is disclosed, comprising: a first rod member having a first zone; a second rod member having a second zone; a first ring member having a first through-hole; and a second ring member having a second through-hole; wherein the first zone contacts the second zone, the first rod member and the second rod member are inserted into the first through-hole and the second through-hole, the first through-hole is fixed to the first rod member, and the second through-hole is fixed to the second rod member. The spine correction apparatus lowers the requirement for repeated surgeries and achieves the purpose of self-correction.

Abstract: The present invention provides a pedicle screw, which includes a screw head, a screw body, a screw rod and a screw cap. The screw body includes a ball-liked arc-shaped buckle portion and a column-liked thread portion. The screw head includes a semi-sphere part with an arc-shaped dimple on one end and a U-shaped cavity on the other end. The U-shaped cavity connects with the arc-shaped dimple. Furthermore, the Arc-shaped dimple connects with the arc-shaped buckle portion. The Arc-shaped dimple includes an opening on its top to allow the screw body passing through. The U-shaped cavity includes an opening, which includes a female thread to fix the screw rod in the U-shaped cavity by a male thread on the screw cap.

Abstract: A spine correction apparatus is disclosed, comprising: a first rod member having a first zone; a second rod member having a second zone; a first ring member having a first through-hole; and a second ring member having a second through-hole; wherein the first zone contacts the second zone, the first rod member and the second rod member are inserted into the first through-hole and the second through-hole, the first through-hole is fixed to the first rod member, and the second through-hole is fixed to the second rod member. The spine correction apparatus lowers the requirement for repeated surgeries and achieves the purpose of self-correction.

Abstract: A solid solution for use in bone regeneration. The solid solution includes two divalent cations, wherein a first divalent cation is calcium ion (Ca2+) and a second divalent cation is selected from the group consisting of magnesium ion (Mg2+), zinc ion (Zn2+), barium ion (Ba2+) and strontium ion (Sr2+). The solid solution also includes at least one anion, and the at least one anion comprises one or more of sulfate (SO42?), phosphate (PO42?), carbonate (CO32?), and silicate (SiO32?).

Abstract: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A??Formula (I) B-A-B-(BOX-B-A-B)n-BOX-B-A-B??Formula (II) wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2?-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.

Abstract: The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C3-C6 molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50° C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

Abstract: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A??(Formula I) and B-A-B-(BOX-B-A-B)n-BOX-B-A-B??Formula (II), wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2?-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.

Abstract: The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C3-C6 molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50° C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

Abstract: The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C3-C6 molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50° C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

Abstract: The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C3-C6 molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50° C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.