Patents by Inventor Prabhakar Kondaji Jadhav
Prabhakar Kondaji Jadhav has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230099739Abstract: The present invention provides a JAK kinase inhibitor and a preparation and application thereof, and the present invention specifically provides a compound having a structure represented in the following formula I, an enantiomer thereof, or a pharmaceutically acceptable salt thereof. The compound has uniquely advantageous JAK kinase inhibitory activity, and as such may be used for treatment of a disease or illness related to JAK kinase activity or expression level.Type: ApplicationFiled: March 10, 2021Publication date: March 30, 2023Inventors: Ao LI, Prabhakar Kondaji JADHAV, Yuanshan YAO, Yile CHEN, Guoqing CAO
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Patent number: 8658693Abstract: The present invention provides novel selective androgen receptor modulators and their salts and pharmaceutical compositions thereof.Type: GrantFiled: October 5, 2012Date of Patent: February 25, 2014Assignee: Eli Lilly and CompanyInventors: Jonathan Edward Green, Prabhakar Kondaji Jadhav, Venkatesh Krishnan, Donald Paul Matthews, Ashraf Saeed, Gregory Alan Stephenson
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Patent number: 8658638Abstract: The present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering Compound (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 4, 2010Date of Patent: February 25, 2014Assignee: Eli Lilly and CompanyInventors: David Andrew Coates, Konstantinos Gavardinas, Prabhakar Kondaji Jadhav
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Patent number: 8486943Abstract: The present invention provides a compound of the Formula (I), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating or preventing physiological disorders, particularly reduced bone mass, osteoporosis, osteopenia, reduced muscle mass or strength, or erectile dysfunction comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 14, 2009Date of Patent: July 16, 2013Assignee: Eli Lilly and CompanyInventors: Prabhakar Kondaji Jadhav, Venkatesh Krishnan, Euibong Jemes Kim
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Patent number: 8227468Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The present invention further provides methods for treating abdominal aortic aneurysm, plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.Type: GrantFiled: October 14, 2011Date of Patent: July 24, 2012Assignee: Eli Lilly and CompanyInventors: Gary G. Deng, Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Euibong Jemes Kim, Matthew Allen Schiffler
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Patent number: 8183388Abstract: The present invention relates to the compound of the formula: to pharmaceutical compositions comprising the compound of Formula (I); and to methods for treating or preventing hypogonadism, osteoporosis, osteopenia, sarcopenia, cachexia, muscle atrophy, sexual dysfunction or erectile dysfunction, comprising administering to a patient in need thereof an effective amount of the compound of Formula (I).Type: GrantFiled: November 10, 2010Date of Patent: May 22, 2012Assignee: Eli Lilly and CompanyInventors: Prabhakar Kondaji Jadhav, Venkatesh Krishnan
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Publication number: 20120095020Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The present invention further provides methods for treating abdominal aortic aneurysm, plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.Type: ApplicationFiled: October 14, 2011Publication date: April 19, 2012Applicant: Eli Lilly and CompanyInventors: Gary G. DENG, Konstantinos GAVARDINAS, Prabhakar Kondaji JADHAV, Euibong Jemes KIM, Matthew Allen SCHIFFLER
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Publication number: 20110312954Abstract: The present invention provides a compound of the formula: Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering Compound (I), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 4, 2010Publication date: December 22, 2011Applicant: ELI LILLY AND COMPANYInventors: David Andrew Coates, Konstantinos Gavardinas, Prabhakar Kondaji Jadhav
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Patent number: 7994164Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 9, 2008Date of Patent: August 9, 2011Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Prabhakar Kondaji Jadhav
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Patent number: 7968587Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.Type: GrantFiled: November 6, 2007Date of Patent: June 28, 2011Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews
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Publication number: 20110118326Abstract: The present invention relates to the compound of the formula: to pharmaceutical compositions comprising the compound of Formula (I); and to methods for treating or preventing hypogonadism, osteoporosis, osteopenia, sarcopenia, cachexia, muscle atrophy, sexual dysfunction or erectile dysfunction, comprising administering to a patient in need thereof an effective amount of the compound of Formula (I).Type: ApplicationFiled: November 10, 2010Publication date: May 19, 2011Applicant: ELI LILLY AND COMPANYInventors: Prabhakar Kondaji Jadhav, Venkatesh Krishnan
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Patent number: 7935722Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of formula (I).Type: GrantFiled: June 21, 2006Date of Patent: May 3, 2011Assignee: Eli Lilly and CompanyInventors: Kevin Robert Fales, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews, David Andrew Neel, Edward C R Smith
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Publication number: 20110039855Abstract: The present invention provides a compound of the Formula (I), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating or preventing physiological disorders, particularly reduced bone mass, osteoporosis, osteopenia, reduced muscle mass or strength, or erectile dysfunction comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 14, 2009Publication date: February 17, 2011Applicant: ELI LILLY AND COMPANYInventors: Prabhakar Kondaji Jadhav, Venkatesh Krishnan, Euibong Jemes Kim
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Patent number: 7807691Abstract: The present invention provides a compound of the Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula (I).Type: GrantFiled: May 10, 2006Date of Patent: October 5, 2010Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Douglas Richard Stack
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Patent number: 7803814Abstract: The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).Type: GrantFiled: December 8, 2004Date of Patent: September 28, 2010Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews
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Patent number: 7728150Abstract: The present invention provides a compound of the formula: Formula (I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, hypertension, and atherosclerosis, comprising administering to a patient in thereof an effective amount of a compound of Formula I.Type: GrantFiled: February 18, 2005Date of Patent: June 1, 2010Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Minmin Wang
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Publication number: 20100069404Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.Type: ApplicationFiled: November 6, 2007Publication date: March 18, 2010Inventors: Konstantinos Gavardinas, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews
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Publication number: 20100022550Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of formula (I).Type: ApplicationFiled: June 21, 2006Publication date: January 28, 2010Applicant: CELLECTISInventors: Kevin Robert Fales, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews, David Andrew Neel, Edward C.R. Smith
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Publication number: 20090163472Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 9, 2008Publication date: June 25, 2009Inventors: Konstantinos GAVARDINAS, Prabhakar Kondaji Jadhav
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Publication number: 20090149445Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.Type: ApplicationFiled: July 15, 2008Publication date: June 11, 2009Inventors: Michael Joseph Coghlan, Jonathan Edward Green, Timothy Alan Grese, Prabhakar Kondaji Jadhav, Donald Paul Matthews, Mitchell Irvin Steinberg, Kevin Robert Fales, Michael Gregory Bell