Patents by Inventor Prasun K. Chakravarty

Prasun K. Chakravarty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Renin inhibitors containing phenylalanyl-histidine replacements
    Patent number: 4839357
    Abstract: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: June 13, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William J. Greenlee, William H. Parsons, Prasun K. Chakravarty
  • Process for preparing ACHPA
    Patent number: 4788322
    Abstract: Process comprising coupling of an acylimidazole-activated derivative of a reduced and protected phenylalanine with the magnesium salt of malonic acid monoethyl ester to produce the beta-ketoester, which is subsequently reduced with NaCNBH.sub.3 /THF in glacial acetic acid to afford a separable mixture of 3-S and 3-R 3-hydroxy-(4S)-4-(N-.alpha.-BOC)amino-5-cyclohexylpentanoic acid, such that large-scale, high yield production of optically-active ACHPA is significantly improved.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: November 29, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Paul F. Schuda, William J. Greenlee, Prasun K. Chakravarty, Philip Escola