Patents by Inventor Prathama Satyendra Mainkar
Prathama Satyendra Mainkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932654Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: GrantFiled: February 9, 2021Date of Patent: March 19, 2024Assignee: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Publication number: 20220333139Abstract: The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.Type: ApplicationFiled: June 17, 2020Publication date: October 20, 2022Applicant: Council of Scientific and Industrial ResearchInventors: Srivari CHANDRASEKHAR, Subhash GHOSH, Avula Shiva KRISHNA, Chada Raji REDDY, Gangarajula SUDHAKAR, Kumaraguru THENKRISHNAN, Srihari PABBARAJA, Prathama Satyendra MAINKAR, Rajesh NASAM
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Patent number: 11072583Abstract: Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R1, R2, R3, R4, R5, and R6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.Type: GrantFiled: August 6, 2018Date of Patent: July 27, 2021Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Chandrasekhar Srivari, Prathama Satyendra Mainkar, Chada Raji Reddy, Srigiridhar Kotamraju, Pavan Kumar Togapur, Subbarao Mohan Venkata Muppidi, Somesh Sharma, Ashok Kumar Jha, Prem Kumar Arumugam
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Publication number: 20210171538Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: ApplicationFiled: February 9, 2021Publication date: June 10, 2021Applicant: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Patent number: 10947249Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: GrantFiled: October 26, 2018Date of Patent: March 16, 2021Inventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Publication number: 20200385349Abstract: Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R1, R2, R3, R4, R5, and R6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.Type: ApplicationFiled: August 6, 2018Publication date: December 10, 2020Inventors: Chandrasekhar SRIVARI, Prathama Satyendra MAINKAR, Chada Raji REDDY, Srigiridhar KOTAMRAJU, Pavan Kumar TOGAPUR, Subbarao Mohan Venkata MUPPIDI, Somesh SHARMA, Ashok Kumar JHA, Prem Kumar ARUMUGAM
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Patent number: 10752585Abstract: The present invention relates to a process for the preparation of (1-alkylindol-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and C—H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by Sp3 C—H activation, reductive hydrogenation and amidation.Type: GrantFiled: August 6, 2018Date of Patent: August 25, 2020Assignee: Council of Scientific & Industrial ResearchInventors: Chandrasekhar Srivari, Prathama Satyendra Mainkar, Srinu Paladugu, Pavan Kumar Togapur
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Publication number: 20200216390Abstract: The present invention relates to a process for the preparation of (1-alkylindo-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and C—H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by Sp3 C—H activation, reductive hydrogenation and amidation.Type: ApplicationFiled: August 6, 2018Publication date: July 9, 2020Inventors: Chandrasekhar SRIVARI, Prathama Satyendra MAINKAR, Srinu PALADUGU, Pavan Kumar TOGAPUR
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Patent number: 10421739Abstract: The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process comprises the following steps: Stetter reaction, reduction-cyclization and methylation.Type: GrantFiled: January 6, 2017Date of Patent: September 24, 2019Assignee: Council of Scientific & Industrial ResearchInventors: Prathama Satyendra Mainkar, Kondepudi Sugnana Sunder, Togapur Pavan Kumar, Srivari Chandrasekhar
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Publication number: 20190211027Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: ApplicationFiled: October 26, 2018Publication date: July 11, 2019Applicant: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Publication number: 20190016699Abstract: The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process comprises the following steps: Stetter reaction, reduction-cyclisation and methylation.Type: ApplicationFiled: January 6, 2017Publication date: January 17, 2019Applicant: Council of Scientific & Industrial ResearchInventors: Prathama Satyendra Mainkar, Kondepudi Sugnana Sunder, Togapur Pavan Kumar, Srivari Chandrasekhar