Patents by Inventor Qizhi Yao

Qizhi Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8987337
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: March 24, 2015
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20150005389
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: September 10, 2014
    Publication date: January 1, 2015
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20150004699
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: September 10, 2014
    Publication date: January 1, 2015
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140378552
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140378478
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140364508
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: December 11, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Patent number: 8895626
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: November 25, 2014
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140336204
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140336205
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Patent number: 8883857
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: November 11, 2014
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Patent number: 8883858
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: November 11, 2014
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140329909
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 6, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140163045
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: March 8, 2013
    Publication date: June 12, 2014
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20130295160
    Abstract: A miR-196a antagonist capable of inhibiting a miR-196a activity, the miR-196a antagonist comprising one or more target sites for miR-196a. Included is also an expression vector comprising a promoter and a nucleic acid insert operably linked to the promoter, wherein the insert encodes one or more miR-196a antagonists capable of inhibiting a miR-196a activity. In one example, the one or more miR-196a antagonists comprise at least one stem-loop structure comprising a guide strand that comprises a sequence that is complementary to miR-196a, the stem-loop structure further comprising a passenger strand that comprises a mismatch.
    Type: Application
    Filed: January 10, 2013
    Publication date: November 7, 2013
    Inventors: Donald Rao, Zhaohui Wang, John J. Nemunaitis, Changyi Chen, Qizhi Yao
  • Publication number: 20130259926
    Abstract: The present invention includes bifunctional shRNAs capable of reducing an expression of a Mesothelin gene; wherein at least one target site sequence of the bifunctional RNA molecule is located within the Mesothelin, wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of Mesothelin.
    Type: Application
    Filed: March 28, 2013
    Publication date: October 3, 2013
    Inventors: Donald Rao, Zhaohui Wang, John J. Nemunaitis, Neil Senzer, Qizhi Yao, Changyi (Johnny) Chen, F. Charles Brunicardi
  • Publication number: 20130121912
    Abstract: A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central tumor suppressive microRNA, miR-198, which is able to both directly and indirectly modulate expression of the various members of this network to alter the molecular makeup of pancreatic tumors. When this tumor signature network is intact, miR-198 expression is reduced and patient survival is dismal; patients with higher miR-198 present an altered tumor signature network, better prognosis and increased survival. Further, MiR-198 replacement reverses tumorigenicity in vitro and in vivo. embodiment of the disclosure is a method of treating cancer in an individual, comprising the step of increasing the level of active microRNA-198 molecules in the pancreatic cancer tumor cells of the individual by an amount sufficient to cause an improvement in the pancreatic cancer in the individual.
    Type: Application
    Filed: August 6, 2012
    Publication date: May 16, 2013
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Qizhi Yao, Christian Marin-Muller, Changyi Chen
  • Publication number: 20100047277
    Abstract: Briefly described, virosomes, methods of preparing virosomes, immunogenic compositions that include virosomes, and methods of eliciting an immune response using immunogenic compositions that include virosomes are described herein. A virosome can include at least one viral surface envelope glycoprotein expressed on the surface of the virosome. The virosome can also optionally include at least one adjuvant molecule expressed on the surface of the virosome.
    Type: Application
    Filed: July 12, 2007
    Publication date: February 25, 2010
    Inventors: Richard W. Compans, Chinglai Yang, Qizhi Yao, Sang-moo Kang
  • Publication number: 20060216702
    Abstract: Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using immunogenic compositions that include virus-like particles are described herein. A virus-like particle (VLP) can include a viral core protein that can self assemble into the VLP core and at least one viral surface envelope glycoprotein expressed on the surface of the VLP. The VLP can also optionally include at least one adjuvant molecule expressed on the surface of the VLP.
    Type: Application
    Filed: April 4, 2006
    Publication date: September 28, 2006
    Inventors: Richard Compans, Chinglai Yang, Qizhi Yao, Sang-moo Kang
  • Publication number: 20060088909
    Abstract: Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of liciting an immune response using immunogenic compositions that include virus-like particles are described herein. A virus-like particle (VLP) can include a viral core protein that can self assemble into the VLP core and at least one viral surface envelope glycoprotein expressed on the surface of the VLP. The viral protein and the viral surface envelope glycoprotein are from different viruses. Another VLP can include a viral core protein that can self assemble into a VLP core; at least one viral surface envelope glycoprotein expressed on the surface of the VLP; and at least one adjuvant molecule expressed on the surface of the VLP.
    Type: Application
    Filed: May 19, 2003
    Publication date: April 27, 2006
    Inventors: Richard Compans, Chinglai Yang, Qizhi Yao, Sang-Moo Kang
  • Patent number: 5969094
    Abstract: A method is provided for detecting whether a test composition can inhibit cell fusion mediated by paramyxovirus infection. A method is also provided for identifying an antiviral peptide capable of inhibiting paramyxovirus-induced cell fusion. The methods are based on the discovery that the hemagglutination and fusion-inducing proteins of paramyxoviruses interact to form a complex termed HN:F, that is prerequisite to cell fusion. Antibodies to HN:F provide a novel means of providing improved immunity against paramyxovirus infection.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: October 19, 1999
    Assignee: Emory University
    Inventors: Richard William Compans, Qizhi Yao