Patents by Inventor R. Lane Smith
R. Lane Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10655104Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within to joint space of diarthrotic joints.Type: GrantFiled: November 25, 2014Date of Patent: May 19, 2020Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Patent number: 9701940Abstract: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.Type: GrantFiled: December 19, 2014Date of Patent: July 11, 2017Assignee: Histogenics CorporationInventors: R. Lane Smith, Laurence J. B. Tarrant, Akihiko Kusanagi, Hans P. I. Claesson
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Publication number: 20160367727Abstract: One-cartilage constructs suitable for implantation into a joint cartilage lesion in sit-up and a method for repair and restoration of function of injured, traumatic, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to the algorithm comprising variable hydrostatic or atmospheric pressure or non-pressure conditions, variable rate of perfusion, variable medium composition, variable temperature, variable cell density and variable time to which the chondrocytes are subjected.Type: ApplicationFiled: June 17, 2016Publication date: December 22, 2016Inventors: Shuichi Mizuno, Akihiko Kusanagi, Laurence J.B. Tarrant, Toshimasa Tokuno, R. Lane Smith
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Publication number: 20160228610Abstract: Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. The progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. In particular, adipose-derived stem cells and chondrocytes, co-encapsulated in a mixed culture in a polyethylene glycol-based hydrogel comprising an extracellular matrix molecule such as chondroitin sulfate methacrylate, hyaluronic acid methacrylate, or heparan sulfate methacrylate, effectively produce cartilage that can be used for treatment of traumatic injuries or diseases involving cartilage degeneration.Type: ApplicationFiled: April 25, 2016Publication date: August 11, 2016Inventors: Janice Lai, William Maloney, R. Lane Smith, Fan Yang
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Patent number: 9393347Abstract: A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.Type: GrantFiled: February 7, 2014Date of Patent: July 19, 2016Assignee: Histogenics CorporationInventors: Hans P. i. Claesson, Laurence J. B. Tarrant, R. Lane Smith, Sonya Shortkroff
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Publication number: 20150104872Abstract: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.Type: ApplicationFiled: December 19, 2014Publication date: April 16, 2015Inventors: R. Lane Smith, Laurence J.B. Tarrant, Akihiko Kusanagi, Hans P.I. Claesson
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Publication number: 20150079048Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within to joint space of diarthrotic joints.Type: ApplicationFiled: November 25, 2014Publication date: March 19, 2015Inventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Patent number: 8921109Abstract: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.Type: GrantFiled: September 19, 2006Date of Patent: December 30, 2014Assignee: Histogenics CorporationInventors: R. Lane Smith, Laurence J. B. Tarrant, Akihiko Kusanagi, Hans Peter Ingemar Claesson
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Publication number: 20140219972Abstract: Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. In particular, progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. For example, adipose-derived stem cells and neonatal articular chondrocytes, co-encapsulated in mixed or bilayered cultures in a hydrogel comprising chondroitin sulfate methacrylate and poly(ethylene)glycol diacrylate, generated cartilage that could be used for treatment of traumatic injuries or diseases involving cartilage degeneration.Type: ApplicationFiled: February 5, 2014Publication date: August 7, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Janice Lai, William Maloney, R. Lane Smith, Fan Yang
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Patent number: 8074487Abstract: A method of calibrating an apparatus for measuring Radon and/or its progeny in an air sample, includes providing an apparatus for measuring Radon in an air sample that includes a preset offset voltage corresponding to a threshold conductivity value and a preselected reading value for indicating a concentration of Radon and/or its progeny, exposing the apparatus to a calibration area for measuring conductivity of the air therein, comparing the measured conductivity value of the air with the preset offset value for conductivity, and setting a lower threshold conductivity value and corresponding threshold reading value same as the preselected reading value, if the measured conductivity of the air is determined to be lower than the preset offset value for conductivity.Type: GrantFiled: March 5, 2009Date of Patent: December 13, 2011Assignee: Durridge Company Inc.Inventor: Derek R. Lane-Smith
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Publication number: 20100224769Abstract: A method of calibrating an apparatus for measuring Radon and/or its progeny in an air sample, includes providing an apparatus for measuring Radon in an air sample that includes a preset offset voltage corresponding to a threshold conductivity value and a preselected reading value for indicating a concentration of Radon and/or its progeny, exposing the apparatus to a calibration area for measuring conductivity of the air therein, comparing the measured conductivity value of the air with the preset offset value for conductivity, and setting a lower threshold conductivity value and corresponding threshold reading value same as the preselected reading value, if the measured conductivity of the air is determined to be lower than the preset offset value for conductivity.Type: ApplicationFiled: March 5, 2009Publication date: September 9, 2010Applicant: DURRIDGE COMPANY INC.Inventor: Derek R. Lane-Smith
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Publication number: 20090227487Abstract: Particle induced inflammatory diseases are treated by administration of an effective dose of an inhibitor of MyD88 adaptor protein.Type: ApplicationFiled: March 4, 2009Publication date: September 10, 2009Inventors: Jeremy Pearl, Ting Ma, William H. Robinson, R. Lane Smith, Stuart B. Goodman
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Publication number: 20090176304Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints.Type: ApplicationFiled: July 11, 2008Publication date: July 9, 2009Inventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Publication number: 20030133915Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints.Type: ApplicationFiled: December 24, 2002Publication date: July 17, 2003Inventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Patent number: 6528052Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints.Type: GrantFiled: September 29, 2000Date of Patent: March 4, 2003Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Patent number: 5536724Abstract: Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins and their 5 and 10 alkyl analogs. A method for the treatment and prevention of inflammatory disease, such as rheumatoid arthritis, and for suppression and prevention of neoplastic growth in tumors and in blood forming tissues. A process for preparation of 10-deazaaminopterins.Type: GrantFiled: October 21, 1993Date of Patent: July 16, 1996Assignees: SRI International, Sloan-Kettering InstituteInventors: Joseph I. DeGraw, William T. Colwell, Francis M. Sirotnak, R. Lane Smith, James R. Piper
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Patent number: 5374550Abstract: Thyroid-derived chondrocyte stimulating factor (TDCSF) is a high molecular weight complex (greater than 500 kd) of proteinaceous subunits which can be at least partially dissociated into active portions by 8M urea. TDCSF stimulates articular chondrocyte and synovial fibroblast growth under serum-free conditions. TDCSF is useful for the culture of chondrocytes and fibroblasts in vitro as a serum substitute; for developing cartilage implants in vitro; and for in vivo use in cartilage and bone defect repair and degenerative joint diseases. TDCSF is stabilized in the presence of reducing agents for disulfide bonds. Antibodies for and conjugates of TDCSF are also disclosed.Type: GrantFiled: November 12, 1993Date of Patent: December 20, 1994Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: R. Lane Smith, Deryk G. Jones
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Patent number: 5354751Abstract: There is disclosed certain heteroaroyl 10-deazaaminopterin and 5, 10 and 8, 10 di deazaminopterin compounds and their use for treatment of rheumatoid arthritis and related diseases and preparative process.Also disclosed are 10 alkenyl-(and alkynyl) 10-deazaminopterins also disclosed for treatment of rheumatoid arthritis and for leukemia and ascites tumors and preparative process.Type: GrantFiled: July 12, 1993Date of Patent: October 11, 1994Assignee: SRI InternationalInventors: Joseph I. DeGraw, William T. Colwell, Francis M. Sirotnak, R. Lane Smith, James R. Piper
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Patent number: 5284830Abstract: Thyroid-derived chondrocyte stimulating factor (TDCSF) is a high molecular weight complex (greater than 500 kd) of proteinaceous subunits which can be at least partially dissociated into active portions by 8 M urea. TDCSF stimulates articular chondrocyte and synovial fibroblast growth under serum-free conditions. TDCSF is useful for the culture of chondrocytes and fibroblasts in vitro as a serum substitute; for developing cartilage implants in vitro; and for in vivo use in cartilage and bone defect repair and degenerative joint diseases. TDCSF is stabilized in the presence of reducing agents for disulfide bonds. Antibodies for and conjugates of TDCSF are also disclosed.Type: GrantFiled: February 13, 1991Date of Patent: February 8, 1994Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: R. Lane Smith, Deryk G. Jones