Patents by Inventor Rachael Sirianni

Rachael Sirianni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220305043
    Abstract: In an embodiment, the present disclosure pertains to a composition. In some embodiments, the composition includes a cross-linked network of cyclic macromolecules. In some embodiments, the cyclic macromolecules are covalently cross-linked to one another by a plurality of cross-linking agents. In some embodiments, at least some of the cross-linking agents are covalently functionalized with a plurality of functional groups. In some embodiments, the plurality of functional groups include a chain of at least three atoms that protrude out of the cross-linking agents. In some embodiments, the cross-linking agents and the functional groups form a polymer matrix, such as poly (?-amino ester). In some embodiments, the composition is in the form of particles. In another embodiment, the present disclosure pertains to a method of administering an active agent to a subject. In some embodiments, the method includes administering a composition of the present disclosure to the subject.
    Type: Application
    Filed: March 25, 2020
    Publication date: September 29, 2022
    Applicant: Board of Regents of The University of Texas System
    Inventors: Sauradip Chaudhuri, Rachael Sirianni
  • Patent number: 11446267
    Abstract: The invention relates to a composition and use of the composition in the treatment of a disorder, for example, a neurological disease associated with retinoid signaling. The invention also includes the use of a retinoid encapsulated in nanoparticles. The retinoid encapsulated nanoparticles are adapted to increasing lifespan and conferring neuroprotective effects such as preserving motor units, reducing motor impairment, or reducing neuroinflammation in a subject.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: September 20, 2022
    Assignee: Dignity Health
    Inventors: Rachael Sirianni, David Alexandro Medina, Eugene Chung
  • Publication number: 20210177760
    Abstract: The methods of manufacture of a drug delivery composition. In some aspects, the methods include providing an organic phase, a biologically active ingredient, and an aqueous phase with a desirable pH (e.g., a pH at which the active ingredient has increased solubility in the aqueous phase compared to at neutral pH). After mixing of one or more of the aforementioned components, the resultant mixture is processed to provide the desired drug delivery composition.
    Type: Application
    Filed: February 26, 2021
    Publication date: June 17, 2021
    Inventors: Rachael Sirianni, Kyle Householder, Danielle Diperna
  • Patent number: 10952967
    Abstract: The methods of manufacture of a drug delivery composition. In some aspects, the methods include providing an organic phase, a biologically active ingredient, and an aqueous phase with a desirable pH (e.g., a pH at which the active ingredient has increased solubility in the aqueous phase compared to at neutral pH). After mixing of one or more of the aforementioned components, the resultant mixture is processed to provide the desired drug delivery composition.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: March 23, 2021
    Assignee: Dignity Health
    Inventors: Rachael Sirianni, Kyle Householder, Danielle Diperna
  • Publication number: 20200339679
    Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
    Type: Application
    Filed: July 14, 2020
    Publication date: October 29, 2020
    Inventors: Rachael Sirianni, Rebecca Cook, Tsafrir Mor, Joseph Blattman
  • Patent number: 10745478
    Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 18, 2020
    Inventors: Rachael Sirianni, Rebecca Cook, Tsafrir Mor, Joseph Blattman
  • Publication number: 20200093769
    Abstract: The invention relates to a composition and use of the composition in the treatment of a disorder, for example, a neurological disease associated with retinoid signaling. The invention also includes the use of a retinoid encapsulated in nanoparticles. The retinoid encapsulated nanoparticles are adapted to increasing lifespan and conferring neuroprotective effects such as preserving motor units, reducing motor impairment, or reducing neuroinflammation in a subject.
    Type: Application
    Filed: June 15, 2018
    Publication date: March 26, 2020
    Inventors: Rachael Sirianni, David Alexandro Medina, Eugene Chung
  • Publication number: 20200054562
    Abstract: The methods of manufacture of a drug delivery composition. In some aspects, the methods include providing an organic phase, a biologically active ingredient, and an aqueous phase with a desirable pH (e.g., a pH at which the active ingredient has increased solubility in the aqueous phase compared to at neutral pH). After mixing of one or more of the aforementioned components, the resultant mixture is processed to provide the desired drug delivery composition.
    Type: Application
    Filed: May 9, 2018
    Publication date: February 20, 2020
    Inventors: Rachael Sirianni, Kyle Householder, Danielle Diperna
  • Publication number: 20190194316
    Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
    Type: Application
    Filed: February 17, 2017
    Publication date: June 27, 2019
    Applicant: Dignity Health
    Inventors: Rachael Sirianni, Rebecca Cook, Tsafrir MOR