Patents by Inventor Rachel Bruckstein

Rachel Bruckstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4675326
    Abstract: A novel series of antidotes against organophosphorus poisoning having both anti-muscarinic activity and reactivation potency, were synthesized and evaluated for their pharmacological efficacy.The compounds are bisquarternary oxybismethylene(or:trimethylene)-bis-N-heterocycles.The N-heterocycles are comprised of 2,3 or 4 mono-substituted pyridines, 3-substituted quinuclidines and 4-substituted N-methylpiperidines (exclusive of both groups in one molecule designating a substituted pyridine ring). Some of the compounds display a remarkably low acute toxicity in mice.These antidotes have been shown to be effective against poisoning by a variety of organophosphorus compounds as well as carbamates. The compounds are also of value as active ingredients in ophthalmic preparations.
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: June 23, 1987
    Inventors: Gabriel Amitai, David Balderman, Rachel Bruckstein-Davidovici, Michael Spiegelstein
  • Patent number: 4472320
    Abstract: There are provided dioxaphosphorinane compounds, a process for the production of these and compositions containing same. These are non-toxic anticholinesterase drugs for the treatment of organophosphorus poisoning, and for the treatment of cholinergic diseases.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: September 18, 1984
    Inventors: Yacov Ashani, Haim Leader, Lily Raveh, Rachel Bruckstein, Michael Spiegelstein