Patents by Inventor Rachel T. Simin

Rachel T. Simin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • G-protein fusion receptors and constructs encoding same
    Patent number: 7262280
    Abstract: The present invention features G-protein fusion receptors and chimeric GABAB receptors (GABABRs), nucleic acid encoding such receptors, and the use of such receptors and nucleic acid. G-protein fusion receptors comprise at least one domain from a CaR, an mGluR, and/or a GABAB receptor fused directly or through a linker to a guanine nucleotide-binding protein (G-protein). Chimeric GABABRs comprise at least one of a GABABR extracellular domain, a GABABR transmembrane domain, or a GABABR intracellular domain and one or more domains from a mGluR subtype 8 (mGluR8) and/or a CaR.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: August 28, 2007
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Thomas M. Stormann, Lance G. Hammerland, Laura L. Storjohann, James G. Busby, James E. Garrett, Rachel T. Simin
  • Human metabotropic glutamate receptor
    Patent number: 6084084
    Abstract: A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR as well as compounds that modulate mGluR activity may be used in the diagnosis and treatment of neurological disorders and diseases.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: July 4, 2000
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Thomas M. Stormann, Rachel T. Simin, Lance G. Hammerland, Forrest H. Fuller
  • Human metabotropic glutamate receptor
    Patent number: 6077675
    Abstract: A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR as well as compounds that modulate mGluR activity may be used in the diagnosis and treatment of neurological disorders and diseases.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: June 20, 2000
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Thomas M. Stormann, Rachel T. Simin, Lance G. Hammerland, Forrest H. Fuller
  • Isolated human metabotropic glutamate receptor Mglur-8
    Patent number: 6051688
    Abstract: A human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR as well as compounds that modulate mGluR activity may be used in the diagnosis and treatment of neurological disorders and diseases.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: April 18, 2000
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Thomas M. Stormann, Rachel T. Simin, Lance G. Hammerland, Forrest H. Fuller