Patents by Inventor Radhakrishnan Venkatasubramanian Tarur

Radhakrishnan Venkatasubramanian Tarur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesis of cyclic octapeptide
    Patent number: 8377891
    Abstract: This invention relates a process for preparing octreotide and derivatives thereof. The starting material, Cys(Trt)-2-Chlorotrityl resin is coupled with various amino acids to obtain a protected heptapeptide of formula (2): Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-2-Chlorotrityl resin. The linear protected peptide of formula (2) is cleaved from the support using TFA5TIS and water to yield linear protected peptide of formula (3) Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-OH Linear protected heptapeptide of formula (3) is deprotected to yield heptapeptide of formula (6): D-Phe-Cys-Phe-D-Tip-Lys-Thr-Cys-OH; which is cyclized using hydrogen peroxide and to the cyclic peptide of formula (7) D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-OH; threoninol is coupled at C terminal to yield octreotide.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: February 19, 2013
    Assignee: USV, Ltd.
    Inventors: Divya Lal Saksena, Digamber Shripati Pawar, Nikhil Umesh Mohe, Nilesh Dagdu Patil, Chandrakesan Muralidharan, Lester Lobo, Radhakrishnan Venkatasubramanian Tarur
  • Process for Synthesis of Cyclic Octapeptide
    Publication number: 20120035117
    Abstract: This invention relates a process for preparing octreotide and derivatives thereof. The starting material, Cys(Trt)-2-Chlorotrityl resin is coupled with various amino acids to obtain a protected heptapeptide of formula (2): Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-2-Chlorotrityl resin. The linear protected peptide of formula (2) is cleaved from the support using TFA5TIS and water to yield linear protected peptide of formula (3) Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-OH Linear protected heptapeptide of formula (3) is deprotected to yield heptapeptide of formula (6): D-Phe-Cys-Phe-D-Tip-Lys-Thr-Cys-OH; which is cyclized using hydrogen peroxide and to the cyclic peptide of formula (7) D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-OH; threoninol is coupled at C terminal to yield octreotide.
    Type: Application
    Filed: May 4, 2009
    Publication date: February 9, 2012
    Inventors: Divya Lal Saksena, Digamber Shripati Pawar, Nikhil Umesh Mohe, Nilesh Dagdu Patil, Chandrakesan Muralidharan, Lester Lobo, Radhakrishnan Venkatasubramanian Tarur
  • Process for the preparation of (R)-(+)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide.
    Publication number: 20100009977
    Abstract: Disclosed herein is an improved process for the preparation of (R)-(+)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide (Brinzolamide) and novel intermediates thereof.
    Type: Application
    Filed: October 12, 2007
    Publication date: January 14, 2010
    Inventors: Dhananjay Govind Sathe, Radhakrishnan Venkatasubramanian Tarur, Nandu Baban Bhise, Ajit Bhaskar Shinde, Santosh Pardeshi