Abstract: The present disclosure relates to nanoparticles for delivering a drug targeting brain cancer, whose surface is modified with a peptide for targeting brain cancer, a preparation method thereof, and a use thereof, and more particularly, to nanoparticles for delivering a drug targeting brain cancer, including porous silicon nanoparticles encapsulating an anticancer drug and a peptide with an ability to target brain cancer cells bound to the surface of the nanoparticles, a preparation method thereof, and a use thereof. The nanoparticles according to the present disclosure can be used as an effective drug delivery system for treating glioblastoma by allowing a conventional anticancer agent exhibiting low tissue specificity and solubility to be specifically delivered to glioblastoma in which a caveolin receptor is overexpressed through the blood-brain barrier to induce a more efficient glioblastoma therapeutic effect.

Abstract: The present invention relates to a silicone polymer compound, a method for preparing same, a composition for transdermal delivery comprising same, and an anti-cancer composition comprising same, wherein a cyclic silane is used as a monomer, and the molecular weight, viscosity, contact angle, moisture content, drug encapsulation ratio, and release behavior of a synthesized silicone polymer compound can be controlled by controlling polymerization conditions such as the type of initiator, ratio of initiator to monomer, and polymerization temperature, and the synthesized silicone polymer compound can thus be used as a transdermal delivery system loaded with a drug and various active substances. In addition, by encapsulating an anticancer agent in the silicone polymer compound of the present invention, the effect of the anticancer agent can be enhanced, and the silicone polymer compound can thus also be utilized for an anticancer use.

Abstract: The present technology relates generally to a method of manufacture comprising: preparing at a first temperature a non-supersaturated solution comprising a micelle forming block copolymer and a drug in a polyethylene glycol (PEG) solvent; and diluting the non-supersaturated solution with water at a second temperature to form an aqueous solution comprising drug-loaded micelles without crystallization of the PEG block(s) of the block copolymer; wherein the block copolymer comprises at least one PEG block and a second biocompatible polymer block that is not PEG, the drug has a water solubility of about or less than 10 mg/mL at 25° C., and the second temperature is lower than the first temperature, but does not allow the cooled solution to become supersaturated.

Abstract: Proposed is a porous silicon nanoparticle with isothiocyanate moiety conjugated to the surface. The porous silicon nanoparticle with isothiocyanate moiety conjugated to the surface has low side effects due to high biocompatibility, and can generate reactive oxygen species in cells without an external initiator, which can promote decomposition and release of supported drugs.

Abstract: The present disclosure relates to nanoparticles for delivering a drug targeting brain cancer, whose surface is modified with a peptide for targeting brain cancer, a preparation method thereof, and a use thereof, and more particularly, to nanoparticles for delivering a drug targeting brain cancer, including porous silicon nanoparticles encapsulating an anticancer drug and a peptide with an ability to target brain cancer cells bound to the surface of the nanoparticles, a preparation method thereof, and a use thereof. The nanoparticles according to the present disclosure can be used as an effective drug delivery system for treating glioblastoma by allowing a conventional anticancer agent exhibiting low tissue specificity and solubility to be specifically delivered to glioblastoma in which a caveolin receptor is overexpressed through the blood-brain barrier to induce a more efficient glioblastoma therapeutic effect.