Patents by Inventor Rae Sung Chang

Rae Sung Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EFFICIENT AQUEOUS ENCAPSULATION AND CONTROLLED RELEASE OF BIOACTIVE AGENTS
    Publication number: 20230201121
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Application
    Filed: February 9, 2023
    Publication date: June 29, 2023
    Inventors: Steven Paul Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman
  • Efficient aqueous encapsulation and controlled release of bioactive agents
    Patent number: 11607387
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: March 21, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman
  • Porous Self-Healing Polymer Matrix For Encapsulation Of Active Macromolecules And Methods
    Publication number: 20220257769
    Abstract: The present disclosure relates to a porous self-healing polymer matrix for encapsulation of active macromolecules and a method of manufacturing said porous self-healing polymer matrix for a drug delivery system for a macromolecule.
    Type: Application
    Filed: July 20, 2020
    Publication date: August 18, 2022
    Inventors: Steven P. Schwendeman, Jason Albert, Rae Sung Chang, George A. Garcia
  • EFFICIENT AQUEOUS ENCAPSULATION AND CONTROLLED RELEASE OF BIOACTIVE AGENTS
    Publication number: 20200022916
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Application
    Filed: August 5, 2019
    Publication date: January 23, 2020
    Inventors: Steven P. Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman
  • Efficient aqueous encapsulation and controlled release of bioactive agents
    Patent number: 10369106
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: August 6, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman
  • COATED IMPLANTS FOR LONG-TERM CONTROLLED RELEASE OF ANTIBODY THERAPEUTICS
    Publication number: 20190151237
    Abstract: Implants for anti-VEGF therapy provide both stability and controlled release of bevacizumab and other structurally sensitive polypeptides while maintaining protein/peptide stability in the micronized powder; achieving near zero order and complete release (>80%). Cylindrical implants suitable for intravitreal injection.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 23, 2019
    Inventors: Steven P. Schwendeman, Rae Sung Chang
  • EFFICIENT AQUEOUS ENCAPSULATION AND CONTROLLED RELEASE OF BIOACTIVE AGENTS
    Publication number: 20150164805
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Application
    Filed: November 10, 2014
    Publication date: June 18, 2015
    Inventors: Steven P. Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman